BACKGROUND The pathological diagnosis and follow-up analysis of gastric mucosal biopsy have been paid much attention,and some scholars have proposed the pathological diagnosis of 12 kinds of lesions and accompanying p...BACKGROUND The pathological diagnosis and follow-up analysis of gastric mucosal biopsy have been paid much attention,and some scholars have proposed the pathological diagnosis of 12 kinds of lesions and accompanying pathological diagnosis,which is of great significance for the treatment of precision gastric diseases,the improvement of the early diagnosis rate of gastric cancer,and the reduction of missed diagnosis rate and misdiagnosis rate.AIM To perform a histopathological classification and follow-up analysis of chronic atrophic gastritis(CAG).METHODS A total of 2248 CAG tissue samples were collected,and data of their clinical characteristics were also gathered.Based on these samples,the expression levels of Mucin 1(MUC1),MUC2,MUC5AC,and MUC6 in CAG tissue were tested by immunohistochemical assay.Moreover,we followed these patients for up to four years.The difference between different stages of gastroscopic biopsy was observed.RESULTS Through observation,it is believed that CAG should be divided into four types,simple type,hyperplasia type,intestinal metaplasia(IM)type,and intraepithelial neoplasia(IEN)type.Simple CAG accounted for 9.1%(205/2248),which was more common in elderly people over 60 years old.The main change was that the lamina propria glands were reduced in size and number.Hyperplastic CAG accounted for 29.1%(654/2248),mostly occurring between 40 and 60 years old.The main change was that the lamina propria glands were atrophy accompanied by glandular hyperplasia and slight expansion of the glands.IM CAG accounted for 50.4%(1132/2248),most of which increased with age,and were more common in those over 50 years.The atrophy of the lamina propria glands was accompanied by significant IM,and the mucus containing sialic acid or sulfate was distinguished according to the nature of the mucus.The IEN type CAG accounted for 11.4%(257/2248),which developed from the previous types,with severe gland atrophy and reduced mucus secretion,and is an important precancerous lesion.CONCLUSION The histological typing of展开更多
目的对国内外ICU后门诊的应用情况进行范围综述。方法以JBI范围综述指南为框架,计算机检索PubMed、Embase、CINAHL、Web of Science、中国知网、万方数据知识服务平台、维普网、中国生物医学文献服务系统(SinoMed)中的相关研究。检索时...目的对国内外ICU后门诊的应用情况进行范围综述。方法以JBI范围综述指南为框架,计算机检索PubMed、Embase、CINAHL、Web of Science、中国知网、万方数据知识服务平台、维普网、中国生物医学文献服务系统(SinoMed)中的相关研究。检索时限为建库至2023年11月28日,对纳入文献进行分析和讨论。结果最终纳入12篇文献,其中中文4篇、英文8篇,发表时间为2003-2023年,分析总结了ICU后门诊的接诊对象、随访时间点、干预措施及应用效果。ICU后门诊改善了患者的心理状态和与心理健康相关的生活质量。结论ICU后门诊在延续护理方面发挥重要作用,但缺乏统一的指南和诊疗流程,未来需探讨ICU后门诊的开展模式,为构建符合我国医疗体系的ICU后门诊提供参考。展开更多
文摘BACKGROUND The pathological diagnosis and follow-up analysis of gastric mucosal biopsy have been paid much attention,and some scholars have proposed the pathological diagnosis of 12 kinds of lesions and accompanying pathological diagnosis,which is of great significance for the treatment of precision gastric diseases,the improvement of the early diagnosis rate of gastric cancer,and the reduction of missed diagnosis rate and misdiagnosis rate.AIM To perform a histopathological classification and follow-up analysis of chronic atrophic gastritis(CAG).METHODS A total of 2248 CAG tissue samples were collected,and data of their clinical characteristics were also gathered.Based on these samples,the expression levels of Mucin 1(MUC1),MUC2,MUC5AC,and MUC6 in CAG tissue were tested by immunohistochemical assay.Moreover,we followed these patients for up to four years.The difference between different stages of gastroscopic biopsy was observed.RESULTS Through observation,it is believed that CAG should be divided into four types,simple type,hyperplasia type,intestinal metaplasia(IM)type,and intraepithelial neoplasia(IEN)type.Simple CAG accounted for 9.1%(205/2248),which was more common in elderly people over 60 years old.The main change was that the lamina propria glands were reduced in size and number.Hyperplastic CAG accounted for 29.1%(654/2248),mostly occurring between 40 and 60 years old.The main change was that the lamina propria glands were atrophy accompanied by glandular hyperplasia and slight expansion of the glands.IM CAG accounted for 50.4%(1132/2248),most of which increased with age,and were more common in those over 50 years.The atrophy of the lamina propria glands was accompanied by significant IM,and the mucus containing sialic acid or sulfate was distinguished according to the nature of the mucus.The IEN type CAG accounted for 11.4%(257/2248),which developed from the previous types,with severe gland atrophy and reduced mucus secretion,and is an important precancerous lesion.CONCLUSION The histological typing of
文摘目的对国内外ICU后门诊的应用情况进行范围综述。方法以JBI范围综述指南为框架,计算机检索PubMed、Embase、CINAHL、Web of Science、中国知网、万方数据知识服务平台、维普网、中国生物医学文献服务系统(SinoMed)中的相关研究。检索时限为建库至2023年11月28日,对纳入文献进行分析和讨论。结果最终纳入12篇文献,其中中文4篇、英文8篇,发表时间为2003-2023年,分析总结了ICU后门诊的接诊对象、随访时间点、干预措施及应用效果。ICU后门诊改善了患者的心理状态和与心理健康相关的生活质量。结论ICU后门诊在延续护理方面发挥重要作用,但缺乏统一的指南和诊疗流程,未来需探讨ICU后门诊的开展模式,为构建符合我国医疗体系的ICU后门诊提供参考。
