Ultrahigh-dose-rate radiotherapy(FLASH-RT)is a revolutionary radiotherapy technology that can spare normal tissues without compromising tumor control.Although qualitative experimental results have been reported,quanti...Ultrahigh-dose-rate radiotherapy(FLASH-RT)is a revolutionary radiotherapy technology that can spare normal tissues without compromising tumor control.Although qualitative experimental results have been reported,quantitative and systematic analysis of data is necessary.Particularly,the FLASH effect response model to the dose or dose rate is still unclear.This study investigated the relationships between the FLASH effect and experimental parameters,such as dose,dose rate,and other factors by analyzing published in vivo experimental data from animal models.The data were modeled based on logistic regression analysis using the sigmoid function.The model was evaluated using prediction accuracy,receiver operating characteristic(ROC)curve,and area under the ROC curve.Results showed that the FLASH effect was closely related to the dose,mean dose rate,tissue type,and corresponding biological endpoints.The dose rate corresponding to a 50% probability of triggering cognitive protection in the brain was 45 Gy s^(-1).The dose rate corresponding to a 50% probability of triggering intestinal crypt survival and regeneration was 140 Gy s^(-1).For the skin toxicity effect,the dose corresponding to a 50% probability of triggering the FLASH effect was 24 Gy.This study helps to characterize the conditions underlying the FLASH effect and provides important information for optimizing experiments.展开更多
During the pre-summer rainy season,heavy rainfall occurs frequently in South China.Based on polarimetric radar observations,the microphysical characteristics and processes of convective features associated with extrem...During the pre-summer rainy season,heavy rainfall occurs frequently in South China.Based on polarimetric radar observations,the microphysical characteristics and processes of convective features associated with extreme rainfall rates(ERCFs)are examined.In the regions with high ERCF occurrence frequency,sub-regional differences are found in the lightning flash rate(LFR)distributions.In the region with higher LFRs,the ERCFs have larger volumes of high reflectivity factor above the freezing level,corresponding to more active riming processes.In addition,these ERCFs are more organized and display larger spatial coverage,which may be related to the stronger low-level wind shear and higher terrain in the region.In the region with lower LFRs,the ERCFs have lower echo tops and lower-echo centroids.However,no clear differences of the most unstable convective available potential energy(MUCAPE)exist in the ERCFs in the regions with different LFR characteristics.Regardless of the LFRs,raindrop collisional coalescence is the main process for the growth of raindrops in the ERCFs.In the ERCFs within the region with lower LFRs,the main mechanism for the rapid increase of liquid water content with decreasing altitude below 4 km is through the warm-rain processes converting cloud drops to raindrops.However,in those with higher LFRs,the liquid water content generally decreases with decreasing altitude.展开更多
The advantages that the rooftop rainwater harvesting system has as a source of water supply have been examined. The observed daily rainfall records of 10 years and the current total roof area of the facilities at Mbey...The advantages that the rooftop rainwater harvesting system has as a source of water supply have been examined. The observed daily rainfall records of 10 years and the current total roof area of the facilities at Mbeya University of Science and Technology as the catchment area were used. Using a water balance model to determine the suitable water use that will cover 100% of the time, the model indicated that for the current roof area a water supply of 120 lts?per day can be met when a storage tank whose capacity is 13.5 m3 is installed. When values higher that 120 l/day are simulated a tank of higher capacity is required to meet the water demand. The study recommends on the necessity of installing rooftop rainwater harvesting system so as to increase the water supply reliability and reduction of cost. The selection of a suitable storage tank capacity should take into consideration the future development plans so as to reduce the construction cost of new storage tank.展开更多
基金supported by the National Key R&D Program of China(No.2022YFC2402300)National Natural Science Foundation of China(No.12075330)。
文摘Ultrahigh-dose-rate radiotherapy(FLASH-RT)is a revolutionary radiotherapy technology that can spare normal tissues without compromising tumor control.Although qualitative experimental results have been reported,quantitative and systematic analysis of data is necessary.Particularly,the FLASH effect response model to the dose or dose rate is still unclear.This study investigated the relationships between the FLASH effect and experimental parameters,such as dose,dose rate,and other factors by analyzing published in vivo experimental data from animal models.The data were modeled based on logistic regression analysis using the sigmoid function.The model was evaluated using prediction accuracy,receiver operating characteristic(ROC)curve,and area under the ROC curve.Results showed that the FLASH effect was closely related to the dose,mean dose rate,tissue type,and corresponding biological endpoints.The dose rate corresponding to a 50% probability of triggering cognitive protection in the brain was 45 Gy s^(-1).The dose rate corresponding to a 50% probability of triggering intestinal crypt survival and regeneration was 140 Gy s^(-1).For the skin toxicity effect,the dose corresponding to a 50% probability of triggering the FLASH effect was 24 Gy.This study helps to characterize the conditions underlying the FLASH effect and provides important information for optimizing experiments.
基金primarily supported by the National Natural Science Foundation of China(Grant Nos.42025501,41905019,and 61827901)the National Key Research and Development Program of China(Grant 2018YFC1506404 and Grant 2017YFC1501703)。
文摘During the pre-summer rainy season,heavy rainfall occurs frequently in South China.Based on polarimetric radar observations,the microphysical characteristics and processes of convective features associated with extreme rainfall rates(ERCFs)are examined.In the regions with high ERCF occurrence frequency,sub-regional differences are found in the lightning flash rate(LFR)distributions.In the region with higher LFRs,the ERCFs have larger volumes of high reflectivity factor above the freezing level,corresponding to more active riming processes.In addition,these ERCFs are more organized and display larger spatial coverage,which may be related to the stronger low-level wind shear and higher terrain in the region.In the region with lower LFRs,the ERCFs have lower echo tops and lower-echo centroids.However,no clear differences of the most unstable convective available potential energy(MUCAPE)exist in the ERCFs in the regions with different LFR characteristics.Regardless of the LFRs,raindrop collisional coalescence is the main process for the growth of raindrops in the ERCFs.In the ERCFs within the region with lower LFRs,the main mechanism for the rapid increase of liquid water content with decreasing altitude below 4 km is through the warm-rain processes converting cloud drops to raindrops.However,in those with higher LFRs,the liquid water content generally decreases with decreasing altitude.
文摘The advantages that the rooftop rainwater harvesting system has as a source of water supply have been examined. The observed daily rainfall records of 10 years and the current total roof area of the facilities at Mbeya University of Science and Technology as the catchment area were used. Using a water balance model to determine the suitable water use that will cover 100% of the time, the model indicated that for the current roof area a water supply of 120 lts?per day can be met when a storage tank whose capacity is 13.5 m3 is installed. When values higher that 120 l/day are simulated a tank of higher capacity is required to meet the water demand. The study recommends on the necessity of installing rooftop rainwater harvesting system so as to increase the water supply reliability and reduction of cost. The selection of a suitable storage tank capacity should take into consideration the future development plans so as to reduce the construction cost of new storage tank.
