Objective To identify patterns of hand, foot and mouth disease （HFMD） incidence in China during declining incidence periods of 2008, 2009, and 2010. Methods Reported HFMD cases over a period of 25 months were extrac...Objective To identify patterns of hand, foot and mouth disease （HFMD） incidence in China during declining incidence periods of 2008, 2009, and 2010. Methods Reported HFMD cases over a period of 25 months were extracted from the National Disease Reporting System （NDRS） and analyzed. An interrupted time series （ITS） technique was used to detect changes in HFMD incidence rates in terms of level and slope between declining incidence periods of the three years. Results Over 3.58 million HFMD cases younger than 5 years were reported to the NDRS between May 1, 2008, and May 31, 2011. Males comprised 63.4% of the cases. ITS analyses demonstrated a significant increase in incidence rate level （P〈0.0001） when comparing the current period with the previous period. There were significant changes in declining slopes when comparing 2010 to 2009, and 2010 to 2008 （all P〈O.O05）, but not 2009 to 2008. Conclusion Incremental changes in incidence rate level during the declining incidence periods of 2009 and 2010 can potentially be attributed to a few factors. The more steeply declining slope in 2010 compared with previous years could be ascribed to the implementation of more effective interventions and preventive strategies in 2010. Further investigation is required to examine this possibility.展开更多
随着COVID-19在全球肆虐,传染病监测有利于阻止传染病传播.而保护监测系统中病人以及数据提供者的隐私能免除他们对隐私信息泄露的顾虑,从而提高系统的数据采集能力.本文提出了一个基于区块链的传染病监测数据聚合方案(lightweight-bloc...随着COVID-19在全球肆虐,传染病监测有利于阻止传染病传播.而保护监测系统中病人以及数据提供者的隐私能免除他们对隐私信息泄露的顾虑,从而提高系统的数据采集能力.本文提出了一个基于区块链的传染病监测数据聚合方案(lightweight-blockchain based privacy-preserving data aggregation scheme,LBPDA),可以在不依赖可信第三方的情况下对数据进行聚合.特别地,为了保护数据聚合过程中数据隐私,采用基于Paillier密码系统的加法同态性来聚合病例数据.此外,为了减少时间开销和存储开销,对使用的Hyperledger Fabric联盟区块链平台进行了改进,从而轻量化数据聚合过程.我们对提出的方案进行了仿真,并进行安全性和性能分析以验证提出方案的可行性和有效性.结果显示,提出的方案能满足政府部门在聚合病例数据用于传染病监测的同时保护病人和数据提供者的隐私的需求.此外,通过对比也证明本文对区块链的轻量化是有效的.展开更多
文摘Objective To identify patterns of hand, foot and mouth disease （HFMD） incidence in China during declining incidence periods of 2008, 2009, and 2010. Methods Reported HFMD cases over a period of 25 months were extracted from the National Disease Reporting System （NDRS） and analyzed. An interrupted time series （ITS） technique was used to detect changes in HFMD incidence rates in terms of level and slope between declining incidence periods of the three years. Results Over 3.58 million HFMD cases younger than 5 years were reported to the NDRS between May 1, 2008, and May 31, 2011. Males comprised 63.4% of the cases. ITS analyses demonstrated a significant increase in incidence rate level （P〈0.0001） when comparing the current period with the previous period. There were significant changes in declining slopes when comparing 2010 to 2009, and 2010 to 2008 （all P〈O.O05）, but not 2009 to 2008. Conclusion Incremental changes in incidence rate level during the declining incidence periods of 2009 and 2010 can potentially be attributed to a few factors. The more steeply declining slope in 2010 compared with previous years could be ascribed to the implementation of more effective interventions and preventive strategies in 2010. Further investigation is required to examine this possibility.
文摘随着COVID-19在全球肆虐,传染病监测有利于阻止传染病传播.而保护监测系统中病人以及数据提供者的隐私能免除他们对隐私信息泄露的顾虑,从而提高系统的数据采集能力.本文提出了一个基于区块链的传染病监测数据聚合方案(lightweight-blockchain based privacy-preserving data aggregation scheme,LBPDA),可以在不依赖可信第三方的情况下对数据进行聚合.特别地,为了保护数据聚合过程中数据隐私,采用基于Paillier密码系统的加法同态性来聚合病例数据.此外,为了减少时间开销和存储开销,对使用的Hyperledger Fabric联盟区块链平台进行了改进,从而轻量化数据聚合过程.我们对提出的方案进行了仿真,并进行安全性和性能分析以验证提出方案的可行性和有效性.结果显示,提出的方案能满足政府部门在聚合病例数据用于传染病监测的同时保护病人和数据提供者的隐私的需求.此外,通过对比也证明本文对区块链的轻量化是有效的.
