In this paper, the activities of electrophilic sites on benzene ring of 4-substituted anilines and their acyl compounds were studied with the quantitative indicator of multiphilicity descriptor. Four substituents were...In this paper, the activities of electrophilic sites on benzene ring of 4-substituted anilines and their acyl compounds were studied with the quantitative indicator of multiphilicity descriptor. Four substituents were synthe- sized with microwave irradiation in good yields to verify the quantitative analysis data. Friedel-Crafts acylation was carried out by the microwave method for the first time.展开更多
Two new compounds, isoquinoline-1, 3-dicarboxyaldehyde and (IDA) were synthesized via 6 or 7 steps starting from benzaldehyde, or prepared via 4 steps starting from allylbenzene.
Ten years after the first synthesis of neutral two-coordinated phosphorus in 1962, the first phosphenium cations were synthesized by Fleming, Lupton and Jekot in 1972. Up to now, though 30 years have passed, the membe...Ten years after the first synthesis of neutral two-coordinated phosphorus in 1962, the first phosphenium cations were synthesized by Fleming, Lupton and Jekot in 1972. Up to now, though 30 years have passed, the members of these phosphenium cations are still very few. the research of phosphenium cations is only limited in France, America and other countries. In our laboratory work was done on a new unique cation: the 5-methylthio-3-N-phenyl-2,3-2(H)-1,3,4,2-thiadiazaphosphenium cation which was found and characterized by 261.9 ppm conclusively of ^(31)p NMR. It also has an electric conductivity in nucleophilic and electrophilic reactions. We are interested in noticing that these phospbenium cations are stabilized by one sulfur atom besides nitrogen atoms.展开更多
A procedure for radioiodination of Cephalexin with iodine-125 was carried out via an electrophilic substitution reaction. Using 3.7 MBq of Na125I, 200μl of cephalexin as substrate, 200 μl of iodogen as oxidizing age...A procedure for radioiodination of Cephalexin with iodine-125 was carried out via an electrophilic substitution reaction. Using 3.7 MBq of Na125I, 200μl of cephalexin as substrate, 200 μl of iodogen as oxidizing agent in acetone at 40°C for 20 min, a maximum radiochemical yield of 125I-Ceph (95%) was obtained. The labeled compound was separated and purified by means of high-pressure liquid chromatography (HPLC). The biological distribution in normal and inflamed (septic and aseptic) mice indicates the suitability of radioiodinated cephalexin for imaging of展开更多
文摘In this paper, the activities of electrophilic sites on benzene ring of 4-substituted anilines and their acyl compounds were studied with the quantitative indicator of multiphilicity descriptor. Four substituents were synthe- sized with microwave irradiation in good yields to verify the quantitative analysis data. Friedel-Crafts acylation was carried out by the microwave method for the first time.
文摘Two new compounds, isoquinoline-1, 3-dicarboxyaldehyde and (IDA) were synthesized via 6 or 7 steps starting from benzaldehyde, or prepared via 4 steps starting from allylbenzene.
基金Project supported by the National Natural Fund for Young Scientists
文摘Ten years after the first synthesis of neutral two-coordinated phosphorus in 1962, the first phosphenium cations were synthesized by Fleming, Lupton and Jekot in 1972. Up to now, though 30 years have passed, the members of these phosphenium cations are still very few. the research of phosphenium cations is only limited in France, America and other countries. In our laboratory work was done on a new unique cation: the 5-methylthio-3-N-phenyl-2,3-2(H)-1,3,4,2-thiadiazaphosphenium cation which was found and characterized by 261.9 ppm conclusively of ^(31)p NMR. It also has an electric conductivity in nucleophilic and electrophilic reactions. We are interested in noticing that these phospbenium cations are stabilized by one sulfur atom besides nitrogen atoms.
文摘A procedure for radioiodination of Cephalexin with iodine-125 was carried out via an electrophilic substitution reaction. Using 3.7 MBq of Na125I, 200μl of cephalexin as substrate, 200 μl of iodogen as oxidizing agent in acetone at 40°C for 20 min, a maximum radiochemical yield of 125I-Ceph (95%) was obtained. The labeled compound was separated and purified by means of high-pressure liquid chromatography (HPLC). The biological distribution in normal and inflamed (septic and aseptic) mice indicates the suitability of radioiodinated cephalexin for imaging of
