Aim: To study the effect of intracavemous sodium nitropmsside (SNP), a nitric oxide (NO) donor, on penile erec-tion. Methods: Forty-two patients with erectile dysfunction (ED) were randomly assigned to receive SNP 300...Aim: To study the effect of intracavemous sodium nitropmsside (SNP), a nitric oxide (NO) donor, on penile erec-tion. Methods: Forty-two patients with erectile dysfunction (ED) were randomly assigned to receive SNP 300μgor the control drags (papaverine 30 mg + phentolamine 1 mg) intracavemously crosswise one week apart. The penilelength, circumference and hardness after the administration of the experimental and control drags were assessed andcompared statistically. Results: (1) There was no significant difference between the changes in penile length andcircumference in the two occasions; (2) In 25 SNP and 28 control cases, the hardness of the penis was scored above100 as evaluated by the Vimg method (P > 0.05); (3) The duration of erection in the controls was longer than that inthe SNP, but there were three priapism in the controls and not a single one in the SNP; (4) there was no apparentchange in the heart rate and blood pressure in both occasions; other side effects were minimal except slight local pain ina few controls. Conclusion: SNP facilitates relaxation of the penile smooth muscle and penile erection without sig-nificant side effects. SNP may be used in ED patients that experience pain and priapism with papaverine/phentolamine.(Asian J Androl 2000 Dec; 2: 301-303)展开更多
目的:探讨经皮穴位电刺激治疗脑卒中后肢体功能障碍的有效性。方法:计算机检索中国知网、万方数据库、维普全文期刊数据库、the Cochrane Library、PubMed、Web of Science、Foreign Medical Journal Service(FMRS)中有关经皮穴位电刺...目的:探讨经皮穴位电刺激治疗脑卒中后肢体功能障碍的有效性。方法:计算机检索中国知网、万方数据库、维普全文期刊数据库、the Cochrane Library、PubMed、Web of Science、Foreign Medical Journal Service(FMRS)中有关经皮穴位电刺激治疗脑卒中后肢体功能障碍的所有随机对照试验(RCT)。由2名研究员分别进行文献筛选和资料提取,借助RevMan 5.4软件进行Meta分析。结果:纳入10篇随机对照试验,涉及735例病人。分析结果显示,干预4周、6周、12周均能够提高脑卒中病人肢体的运动功能[WMD=7.29,95%CI(5.17,9.42),P<0.00001],且对上肢和下肢的运动功能恢复均有效[WMD=7.29,95%CI(5.17,9.42),P<0.00001]。此外,此干预对病人日常生活能力也有提高[WMD=8.21,95%CI(5.27,11.14),P<0.00001]。结论:现有证据表明,经皮穴位电刺激可以改善脑卒中后肢体功能障碍病人的运动功能,提高日常生活能力。展开更多
文摘Aim: To study the effect of intracavemous sodium nitropmsside (SNP), a nitric oxide (NO) donor, on penile erec-tion. Methods: Forty-two patients with erectile dysfunction (ED) were randomly assigned to receive SNP 300μgor the control drags (papaverine 30 mg + phentolamine 1 mg) intracavemously crosswise one week apart. The penilelength, circumference and hardness after the administration of the experimental and control drags were assessed andcompared statistically. Results: (1) There was no significant difference between the changes in penile length andcircumference in the two occasions; (2) In 25 SNP and 28 control cases, the hardness of the penis was scored above100 as evaluated by the Vimg method (P > 0.05); (3) The duration of erection in the controls was longer than that inthe SNP, but there were three priapism in the controls and not a single one in the SNP; (4) there was no apparentchange in the heart rate and blood pressure in both occasions; other side effects were minimal except slight local pain ina few controls. Conclusion: SNP facilitates relaxation of the penile smooth muscle and penile erection without sig-nificant side effects. SNP may be used in ED patients that experience pain and priapism with papaverine/phentolamine.(Asian J Androl 2000 Dec; 2: 301-303)
文摘目的:探讨经皮穴位电刺激治疗脑卒中后肢体功能障碍的有效性。方法:计算机检索中国知网、万方数据库、维普全文期刊数据库、the Cochrane Library、PubMed、Web of Science、Foreign Medical Journal Service(FMRS)中有关经皮穴位电刺激治疗脑卒中后肢体功能障碍的所有随机对照试验(RCT)。由2名研究员分别进行文献筛选和资料提取,借助RevMan 5.4软件进行Meta分析。结果:纳入10篇随机对照试验,涉及735例病人。分析结果显示,干预4周、6周、12周均能够提高脑卒中病人肢体的运动功能[WMD=7.29,95%CI(5.17,9.42),P<0.00001],且对上肢和下肢的运动功能恢复均有效[WMD=7.29,95%CI(5.17,9.42),P<0.00001]。此外,此干预对病人日常生活能力也有提高[WMD=8.21,95%CI(5.27,11.14),P<0.00001]。结论:现有证据表明,经皮穴位电刺激可以改善脑卒中后肢体功能障碍病人的运动功能,提高日常生活能力。
