目的通过荟萃分析研究睡眠时间长短与高血压发生风险的相关性，为高血压的一级预防提供依据。方法计算机检索PubMed、Cochrane数据库、中国期刊全文数据库、维普中文期刊数据库及万方数据库，检索年限均为建库至2012-02，辅以其他检索...目的通过荟萃分析研究睡眠时间长短与高血压发生风险的相关性，为高血压的一级预防提供依据。方法计算机检索PubMed、Cochrane数据库、中国期刊全文数据库、维普中文期刊数据库及万方数据库，检索年限均为建库至2012-02，辅以其他检索方式，收集探索睡眠时间与高血压之间相关性的横断面观察性研究。由两名研究者按Cochrane系统评价方法，进行筛选、评价质量及提取资料，并用Stata11.0软件进行荟萃分析、发表偏倚分析及敏感性分析等统计分析。结果共纳入成人相关研究24篇，总计264 978人，荟萃分析结果显示睡眠时间过短与患高血压的风险增加有关，睡眠时间≤5 h或≤6 h均与患高血压风险增高有关（≤5 h：OR 1.19，95% CI 1.04-1.36；≤6 h：OR 1.28，95% CI 1.11-1.47，均P〈0.05），而并未发现睡眠时间≤7 h与患高血压风险增加有关（OR 1.12，95% CI 0.88-1.42）。睡眠时间过长也与患高血压风险增加有关（≥9 h：OR 1.13，95% CI 1.04-1.23，P〈0.05）。异质性分析结果提示文献来源的地区分布是异质性来源之一。Begg＇s检验和Egger＇s检验表明无发表偏倚。敏感性分析示本次荟萃分析结果稳定性较好。结论成人睡眠时间与高血压在观察性研究层面上存在U形曲线关系。展开更多
目的了解我国中老年人高血压发病情况,并探讨睡眠时间和睡眠质量与我国中老年人高血压发病率之间的关系。方法运用2011年和2015年中国健康与养老追踪调查数据(China health and retirement longitudinal study,CHARLS),共纳入45岁及以...目的了解我国中老年人高血压发病情况,并探讨睡眠时间和睡眠质量与我国中老年人高血压发病率之间的关系。方法运用2011年和2015年中国健康与养老追踪调查数据(China health and retirement longitudinal study,CHARLS),共纳入45岁及以上中老年6 047人。睡眠时间被定义为过去1个月平均每晚的实际睡眠时间,睡眠质量应用自编问卷进行评估。睡眠时间和睡眠质量对高血压发病率的影响采用多因素Logistic回归模型分析。结果经过4年随访,1 151人发生了高血压,累积发病率为19.03%。多因素Logistic回归模型分析结果显示,单纯睡眠时间异常或睡眠质量不佳均对高血压发病率无影响,在性别、年龄的亚组分析中结果保持不变。进一步研究不同组合的睡眠时间和睡眠质量与高血压的关系,结果显示睡眠时间和睡眠质量与高血压的联合效应差异均无统计学意义(均有P>0.05)。结论无充分证据显示睡眠时间和睡眠质量与我国中老年高血压发病率有关且年龄、性别对该相关性无影响。展开更多
Background Hypertension （HTN） is a very prevalent public health problem and as the population ages,cognitive impairment （CI） is also going to be a public health burden.However,the relationship between hypertension...Background Hypertension （HTN） is a very prevalent public health problem and as the population ages,cognitive impairment （CI） is also going to be a public health burden.However,the relationship between hypertension duration and cognitive function declination worldwide is still unknown.The aim of the study was to investigate the effects of HTN duration on CI in Chinese population.Methods At baseline,1 386 HTN patients and 293 normotensive （NT） people were enrolled.The HTN patients were further divided into four subgroups （duration of HTN 〈6 years,6-10 years,11-20 years,and 〉20 years） according to the HTN duration and were screened for cognitive function with neuropsychological tests including mini-mental-state-examination （MMSE） and clock-drawing-test （CDT） in comparison with the NT group.Results More HTN patients had CI （45.3%） than NT subjects （30.4%）,and increased with HTN duration （P〈0.000 1）.Compared with the scores of MMSE and CDT in the NT group,the declines were higher in the HTN patients （P 〈0.000 1）,and in the four HTN subgroups,both MMSE and CDT scores fall when the HTN duration increased （P 〈0.05）.Furthermore,in the HTN population without CI,the trend in alteration of CI was relatively mild but still existed （P 〈0.05）.Conclusion People with HTN are more likely to have CI and the possibility and aggravation increases the prolongation of HTN duration,both in amnesic and nonamnesic function.展开更多
文摘目的通过荟萃分析研究睡眠时间长短与高血压发生风险的相关性，为高血压的一级预防提供依据。方法计算机检索PubMed、Cochrane数据库、中国期刊全文数据库、维普中文期刊数据库及万方数据库，检索年限均为建库至2012-02，辅以其他检索方式，收集探索睡眠时间与高血压之间相关性的横断面观察性研究。由两名研究者按Cochrane系统评价方法，进行筛选、评价质量及提取资料，并用Stata11.0软件进行荟萃分析、发表偏倚分析及敏感性分析等统计分析。结果共纳入成人相关研究24篇，总计264 978人，荟萃分析结果显示睡眠时间过短与患高血压的风险增加有关，睡眠时间≤5 h或≤6 h均与患高血压风险增高有关（≤5 h：OR 1.19，95% CI 1.04-1.36；≤6 h：OR 1.28，95% CI 1.11-1.47，均P〈0.05），而并未发现睡眠时间≤7 h与患高血压风险增加有关（OR 1.12，95% CI 0.88-1.42）。睡眠时间过长也与患高血压风险增加有关（≥9 h：OR 1.13，95% CI 1.04-1.23，P〈0.05）。异质性分析结果提示文献来源的地区分布是异质性来源之一。Begg＇s检验和Egger＇s检验表明无发表偏倚。敏感性分析示本次荟萃分析结果稳定性较好。结论成人睡眠时间与高血压在观察性研究层面上存在U形曲线关系。
文摘目的了解我国中老年人高血压发病情况,并探讨睡眠时间和睡眠质量与我国中老年人高血压发病率之间的关系。方法运用2011年和2015年中国健康与养老追踪调查数据(China health and retirement longitudinal study,CHARLS),共纳入45岁及以上中老年6 047人。睡眠时间被定义为过去1个月平均每晚的实际睡眠时间,睡眠质量应用自编问卷进行评估。睡眠时间和睡眠质量对高血压发病率的影响采用多因素Logistic回归模型分析。结果经过4年随访,1 151人发生了高血压,累积发病率为19.03%。多因素Logistic回归模型分析结果显示,单纯睡眠时间异常或睡眠质量不佳均对高血压发病率无影响,在性别、年龄的亚组分析中结果保持不变。进一步研究不同组合的睡眠时间和睡眠质量与高血压的关系,结果显示睡眠时间和睡眠质量与高血压的联合效应差异均无统计学意义(均有P>0.05)。结论无充分证据显示睡眠时间和睡眠质量与我国中老年高血压发病率有关且年龄、性别对该相关性无影响。
文摘Background Hypertension （HTN） is a very prevalent public health problem and as the population ages,cognitive impairment （CI） is also going to be a public health burden.However,the relationship between hypertension duration and cognitive function declination worldwide is still unknown.The aim of the study was to investigate the effects of HTN duration on CI in Chinese population.Methods At baseline,1 386 HTN patients and 293 normotensive （NT） people were enrolled.The HTN patients were further divided into four subgroups （duration of HTN 〈6 years,6-10 years,11-20 years,and 〉20 years） according to the HTN duration and were screened for cognitive function with neuropsychological tests including mini-mental-state-examination （MMSE） and clock-drawing-test （CDT） in comparison with the NT group.Results More HTN patients had CI （45.3%） than NT subjects （30.4%）,and increased with HTN duration （P〈0.000 1）.Compared with the scores of MMSE and CDT in the NT group,the declines were higher in the HTN patients （P 〈0.000 1）,and in the four HTN subgroups,both MMSE and CDT scores fall when the HTN duration increased （P 〈0.05）.Furthermore,in the HTN population without CI,the trend in alteration of CI was relatively mild but still existed （P 〈0.05）.Conclusion People with HTN are more likely to have CI and the possibility and aggravation increases the prolongation of HTN duration,both in amnesic and nonamnesic function.
