The slightly water-soluble anticancer drug camptothecin(CPT) and its inclusion complexes with cucurbit[n = 7,8]uril(Q[n](n = 7,8)) were investigated.The formation of 1:2 complexes with Q[n](n = 7,8) in aqueous solutio...The slightly water-soluble anticancer drug camptothecin(CPT) and its inclusion complexes with cucurbit[n = 7,8]uril(Q[n](n = 7,8)) were investigated.The formation of 1:2 complexes with Q[n](n = 7,8) in aqueous solution was confirmed by fluorescence spectroscopy and the apparent stability constants were determined to be higher than 3.01 × 1012 L2/mol2.The solid inclusion complexes of CPT and Q[n](n = 7,8) were also prepared by the co-evaporation method and characterized by Fourier transformation-infrared spectroscopy,differential scanning calorimetry and powder X-ray diffraction.Aqueous solubility and dissolution studies indicate that the complexes exhibited significantly increased dissolution rates compared with the pure drug and physical mixtures.The potential of Q[7] or Q[8] for stabilizing lactone modality of CPT was investigated by the High Performance Liquid Chromatography(HPLC) method.The results reveal more than 63% CPT lactone form(active form) in CPT-Q[7] or Q[8] complexes compared to only 36% CPT lactone form in the absence of Q[7] or Q[8] after being incubated in the phosphate buffer solution(pH 7.4 at 37 °C) for 5h.展开更多
豆奶粉流动性和分散性差是导致豆奶粉冲调结团的重要原因,而导致豆奶粉流动性和分散性差的重要原因则是表面不光滑和吸潮。作者研究了利用阿拉伯树胶,羧甲基纤维素钠,β—环糊精对豆奶粉颗粒进行外涂膜以改善其流动性和分散性,结果表明...豆奶粉流动性和分散性差是导致豆奶粉冲调结团的重要原因,而导致豆奶粉流动性和分散性差的重要原因则是表面不光滑和吸潮。作者研究了利用阿拉伯树胶,羧甲基纤维素钠,β—环糊精对豆奶粉颗粒进行外涂膜以改善其流动性和分散性,结果表明:单独喷涂阿拉伯树胶2-0 g/100 g 豆奶粉,羧甲基纤维素钠0-369 g/100 g 豆奶粉,β—环糊精1-0 g/100 g 豆奶粉均能防止冲调结团并具有较好的防潮能力。同时喷涂阿拉伯树胶1-0 g/100 g 豆奶粉,羧甲基纤维素钠0-246 g/100 g 豆奶粉,β—环糊精1-0 g/100 g 豆奶粉时,不但能防止豆奶粉冲调结团。展开更多
基金supported by the Talented Person Project of Guizhou University (2007016)Science and Technology Fund of Guizhou Province (20082294)Governor Foundations of Guizhou Province (200812)
文摘The slightly water-soluble anticancer drug camptothecin(CPT) and its inclusion complexes with cucurbit[n = 7,8]uril(Q[n](n = 7,8)) were investigated.The formation of 1:2 complexes with Q[n](n = 7,8) in aqueous solution was confirmed by fluorescence spectroscopy and the apparent stability constants were determined to be higher than 3.01 × 1012 L2/mol2.The solid inclusion complexes of CPT and Q[n](n = 7,8) were also prepared by the co-evaporation method and characterized by Fourier transformation-infrared spectroscopy,differential scanning calorimetry and powder X-ray diffraction.Aqueous solubility and dissolution studies indicate that the complexes exhibited significantly increased dissolution rates compared with the pure drug and physical mixtures.The potential of Q[7] or Q[8] for stabilizing lactone modality of CPT was investigated by the High Performance Liquid Chromatography(HPLC) method.The results reveal more than 63% CPT lactone form(active form) in CPT-Q[7] or Q[8] complexes compared to only 36% CPT lactone form in the absence of Q[7] or Q[8] after being incubated in the phosphate buffer solution(pH 7.4 at 37 °C) for 5h.
文摘豆奶粉流动性和分散性差是导致豆奶粉冲调结团的重要原因,而导致豆奶粉流动性和分散性差的重要原因则是表面不光滑和吸潮。作者研究了利用阿拉伯树胶,羧甲基纤维素钠,β—环糊精对豆奶粉颗粒进行外涂膜以改善其流动性和分散性,结果表明:单独喷涂阿拉伯树胶2-0 g/100 g 豆奶粉,羧甲基纤维素钠0-369 g/100 g 豆奶粉,β—环糊精1-0 g/100 g 豆奶粉均能防止冲调结团并具有较好的防潮能力。同时喷涂阿拉伯树胶1-0 g/100 g 豆奶粉,羧甲基纤维素钠0-246 g/100 g 豆奶粉,β—环糊精1-0 g/100 g 豆奶粉时,不但能防止豆奶粉冲调结团。
