The dispersion of ultrafine particles in the air can be achieved by mechanical method or surface modification. In this work, the electrostatic technique was first employed for anti-aggregation of ultrafine particles. ...The dispersion of ultrafine particles in the air can be achieved by mechanical method or surface modification. In this work, the electrostatic technique was first employed for anti-aggregation of ultrafine particles. When the relative humidity of the air is within the region of 70%-75%, effective storage time of ultrafine particles can reach 72 h after treatment by the electrostatic technique. The experimental results showed that this technique imparted ultrafine particles much more pronounced anti-aggregation property. In the dry air, the critical diameter of ultrafine particles anti-aggregated by the electrostatic technique is the function of particle property and charging field intensity. The critical diameter is inversely proportional to the square of the charging field intensity.展开更多
Aim To improve the dissolution rate and bioavailability of silybin. Methods Sustained-release silybin microspheres were prepared by the spherical crystallization technique with soliddispersing and release-retarding po...Aim To improve the dissolution rate and bioavailability of silybin. Methods Sustained-release silybin microspheres were prepared by the spherical crystallization technique with soliddispersing and release-retarding polymers. A differential scanning calorimeter and an X-ray diffractometer were used to investigate the dispersion state of silybin in the microspheres. The shape, surface morphology, and internal structure of the microspheres were observed using a scanning electron microscope. Characterization of the microspheres, such as average diameter, size distribution and bulk density of the microspheres was investigated. Results The particle size of the microspheres was determined mainly by the agitation speed. The dissolution rate of silybin from microspheres was enhanced by increasing the amount of the dispersing agents, and sustained by the retarding agents. The release rate of microspheres was controlled by adjusting the combination ratio of the dispersing agents to the retarding agents. The resuits of X-ray diffraction and differential scanning calorimetry analysis indicated that silybin was highly dispersed in the microspheres in amorphous state. The release profiles and content did not change after a three-month accelerated stability test at 40 ℃ and 75% relative humidity. Conclusion Sustained-release silybin microspheres with a solid dispersion structure were prepared successfully in one step by a spherical crystallization technique combined with solid dispersion technique. The preparation process is simple, reproducible and inexpensive. The method is efficient for designing sustained-release microspheres with water-insoluble drugs.展开更多
This paper deals with the study of propagation of G type waves along the plane surface at the interface of two different types of media. The upper medium is taken as monoclinic magnetoelastic layer whereas the lower h...This paper deals with the study of propagation of G type waves along the plane surface at the interface of two different types of media. The upper medium is taken as monoclinic magnetoelastic layer whereas the lower half-space is inhomogeneous isotropic. Dispersion equation and condition for maximum energy flow near the surface are obtained in compact form. The dispersion equation is in assertion with the classical Love-type wave equation for the isotropic case. Effect of magnetic field and inhomogeneity on phase velocity and variation of group velocity with scaled wave number has been depicted by means of graphs. It is observed that inhomogenetity decreases phase velocity and the magnetic field has the favouring effect. A comparative study for the case of isotropic layer and monoclinic layer over the same isotropic inhomogeneous half space has been made through graphs.展开更多
基金This work was supported by the National Natural Science Foundation of China (Grant No. 59574031).
文摘The dispersion of ultrafine particles in the air can be achieved by mechanical method or surface modification. In this work, the electrostatic technique was first employed for anti-aggregation of ultrafine particles. When the relative humidity of the air is within the region of 70%-75%, effective storage time of ultrafine particles can reach 72 h after treatment by the electrostatic technique. The experimental results showed that this technique imparted ultrafine particles much more pronounced anti-aggregation property. In the dry air, the critical diameter of ultrafine particles anti-aggregated by the electrostatic technique is the function of particle property and charging field intensity. The critical diameter is inversely proportional to the square of the charging field intensity.
文摘Aim To improve the dissolution rate and bioavailability of silybin. Methods Sustained-release silybin microspheres were prepared by the spherical crystallization technique with soliddispersing and release-retarding polymers. A differential scanning calorimeter and an X-ray diffractometer were used to investigate the dispersion state of silybin in the microspheres. The shape, surface morphology, and internal structure of the microspheres were observed using a scanning electron microscope. Characterization of the microspheres, such as average diameter, size distribution and bulk density of the microspheres was investigated. Results The particle size of the microspheres was determined mainly by the agitation speed. The dissolution rate of silybin from microspheres was enhanced by increasing the amount of the dispersing agents, and sustained by the retarding agents. The release rate of microspheres was controlled by adjusting the combination ratio of the dispersing agents to the retarding agents. The resuits of X-ray diffraction and differential scanning calorimetry analysis indicated that silybin was highly dispersed in the microspheres in amorphous state. The release profiles and content did not change after a three-month accelerated stability test at 40 ℃ and 75% relative humidity. Conclusion Sustained-release silybin microspheres with a solid dispersion structure were prepared successfully in one step by a spherical crystallization technique combined with solid dispersion technique. The preparation process is simple, reproducible and inexpensive. The method is efficient for designing sustained-release microspheres with water-insoluble drugs.
文摘This paper deals with the study of propagation of G type waves along the plane surface at the interface of two different types of media. The upper medium is taken as monoclinic magnetoelastic layer whereas the lower half-space is inhomogeneous isotropic. Dispersion equation and condition for maximum energy flow near the surface are obtained in compact form. The dispersion equation is in assertion with the classical Love-type wave equation for the isotropic case. Effect of magnetic field and inhomogeneity on phase velocity and variation of group velocity with scaled wave number has been depicted by means of graphs. It is observed that inhomogenetity decreases phase velocity and the magnetic field has the favouring effect. A comparative study for the case of isotropic layer and monoclinic layer over the same isotropic inhomogeneous half space has been made through graphs.
