美国在以《州共同核心标准》为标志的新一轮改革中,明确提出以"College and Career Readiness"作为高中教育目标。系统地梳理该方面的已有研究发现,"College and Career Readiness"并非是"为升学和就业做准备&...美国在以《州共同核心标准》为标志的新一轮改革中,明确提出以"College and Career Readiness"作为高中教育目标。系统地梳理该方面的已有研究发现,"College and Career Readiness"并非是"为升学和就业做准备",而是"为大学学习和职业生涯做准备";"为大学学习和职业生涯做准备"的内涵可以从"准备"、"成功"或兼含"准备"和"成功"之义的角度明晰之。以"为大学学习和职业生涯做准备"作为美国高中教育目标是基于一些组织和学者所做的大量实证研究为据而确定的,同时也是国际比较的产物;尽管该目标的确定是理性的过程,但从教育目标的价值追求、性质和内容的角度看,其局限性仍然是不言而喻的。展开更多
Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cel...Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cells of epithelial origin that promotes metastasis, drug resistance and cancer stem cell formation. Since the information regarding differential gene expression in TNBC cells and cell signaling events leading to EMT is limited, this investigation was done by comparing transcriptomic data generated by RNA isolation and sequencing of a EMT model TNBC cell line in comparison to regular TNBC cells. RNA sequencing and Ingenuity Pathway Software Analysis (IPA) of the transcriptomic data revealed several upregulated and downregulated gene expressions along with novel core canonical pathways including Sirtuin signaling, Oxidative Phosphorylation and Mitochondrial dysfunction events involved in EMT changes of the TNBC cells.展开更多
文摘美国在以《州共同核心标准》为标志的新一轮改革中,明确提出以"College and Career Readiness"作为高中教育目标。系统地梳理该方面的已有研究发现,"College and Career Readiness"并非是"为升学和就业做准备",而是"为大学学习和职业生涯做准备";"为大学学习和职业生涯做准备"的内涵可以从"准备"、"成功"或兼含"准备"和"成功"之义的角度明晰之。以"为大学学习和职业生涯做准备"作为美国高中教育目标是基于一些组织和学者所做的大量实证研究为据而确定的,同时也是国际比较的产物;尽管该目标的确定是理性的过程,但从教育目标的价值追求、性质和内容的角度看,其局限性仍然是不言而喻的。
文摘Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cells of epithelial origin that promotes metastasis, drug resistance and cancer stem cell formation. Since the information regarding differential gene expression in TNBC cells and cell signaling events leading to EMT is limited, this investigation was done by comparing transcriptomic data generated by RNA isolation and sequencing of a EMT model TNBC cell line in comparison to regular TNBC cells. RNA sequencing and Ingenuity Pathway Software Analysis (IPA) of the transcriptomic data revealed several upregulated and downregulated gene expressions along with novel core canonical pathways including Sirtuin signaling, Oxidative Phosphorylation and Mitochondrial dysfunction events involved in EMT changes of the TNBC cells.
