Lung cancer is the leading cause of cancer deaths worldwide. Accurate early diagnosis is critical in increasing the 5-year survival rate of lung cancer, so the efficient and accurate detection of lung nodules,the pote...Lung cancer is the leading cause of cancer deaths worldwide. Accurate early diagnosis is critical in increasing the 5-year survival rate of lung cancer, so the efficient and accurate detection of lung nodules,the potential precursors to lung cancer, is paramount. In this paper, a computer-aided lung nodule detection system using 3D deep convolutional neural networks(CNNs) is developed. The first multi-scale 11-layer 3D fully convolutional neural network(FCN) is used for screening all lung nodule candidates. Considering relative small sizes of lung nodules and limited memory, the input of the FCN consists of 3D image patches rather than of whole images. The candidates are further classified in the second CNN to get the final result. The proposed method achieves high performance in the LUNA16 challenge and demonstrates the effectiveness of using 3D deep CNNs for lung nodule detection.展开更多
Detection of small pulmonary nodules is the goal of lung cancer screening. Computer-aided detection (CAD) systems are recommended to use in lung cancer computed tomography (CT) screening to increase the accuracy of no...Detection of small pulmonary nodules is the goal of lung cancer screening. Computer-aided detection (CAD) systems are recommended to use in lung cancer computed tomography (CT) screening to increase the accuracy of nodule detection. Size and density of lung nodules are primary factors in determining the risk of malignancy. Therefore, purpose of this study is to apply computer-simulated virtual nodules based on the point spread function (PSF) measured in same scanner (maintaining spatial resolution condition) to assess the CAD system performance dependence on nodule size and density. Virtual nodules with density differences between lung background and nodule density (ΔCT) values (200, 300 and 400 HU) and different sizes (4 to 8 mm) were generated and fused on clinical images. CAD detection was performed and free-response receiver operating characteristic (FROC) curves were obtained. Results show that both density and size of virtual nodules can affect detection efficiency. Detailed results are possible to use for quantitative analysis of a CAD system performance. This study suggests that PSF-based virtual nodules could be effectively used to assess the lung cancer CT screening CAD system performance dependence on nodule size and density.展开更多
CT colonography （CTC） is a non-invasive screening technique for the detection of eolorectal polyps, as an alternative to optical colonoscopy in clinical practice. Computer-aided detection （CAD） for CTC refers to a...CT colonography （CTC） is a non-invasive screening technique for the detection of eolorectal polyps, as an alternative to optical colonoscopy in clinical practice. Computer-aided detection （CAD） for CTC refers to a scheme which automatically detects colorectal polyps and masses in CT images of the colon. It has the potential to increase radiologists＇ detection performance and greatly shorten the detection time. Over the years, technical developments have advanced CAD for CTC substantially. In this paper, key techniques used in CAD for polyp detection are reviewed. Illustrations about the performance of existing CAD schemes show their relatively high sensitivity and low false positive rate. However, these CAD schemes are still suffering from technical or clinical problems. Some existing challenges faced by CAD are also pointed out at the end of this paper.展开更多
基金the National Natural Science Foundation of China(No.81371624)the National Key Research and Development Program of China(No.2016YFC0104608)+1 种基金the National Basic Research Program of China(No.2010CB834302)the Shanghai Jiao Tong University Medical Engineering Cross Research Funds(Nos.YG2013MS30 and YG2014ZD05)
文摘Lung cancer is the leading cause of cancer deaths worldwide. Accurate early diagnosis is critical in increasing the 5-year survival rate of lung cancer, so the efficient and accurate detection of lung nodules,the potential precursors to lung cancer, is paramount. In this paper, a computer-aided lung nodule detection system using 3D deep convolutional neural networks(CNNs) is developed. The first multi-scale 11-layer 3D fully convolutional neural network(FCN) is used for screening all lung nodule candidates. Considering relative small sizes of lung nodules and limited memory, the input of the FCN consists of 3D image patches rather than of whole images. The candidates are further classified in the second CNN to get the final result. The proposed method achieves high performance in the LUNA16 challenge and demonstrates the effectiveness of using 3D deep CNNs for lung nodule detection.
文摘Detection of small pulmonary nodules is the goal of lung cancer screening. Computer-aided detection (CAD) systems are recommended to use in lung cancer computed tomography (CT) screening to increase the accuracy of nodule detection. Size and density of lung nodules are primary factors in determining the risk of malignancy. Therefore, purpose of this study is to apply computer-simulated virtual nodules based on the point spread function (PSF) measured in same scanner (maintaining spatial resolution condition) to assess the CAD system performance dependence on nodule size and density. Virtual nodules with density differences between lung background and nodule density (ΔCT) values (200, 300 and 400 HU) and different sizes (4 to 8 mm) were generated and fused on clinical images. CAD detection was performed and free-response receiver operating characteristic (FROC) curves were obtained. Results show that both density and size of virtual nodules can affect detection efficiency. Detailed results are possible to use for quantitative analysis of a CAD system performance. This study suggests that PSF-based virtual nodules could be effectively used to assess the lung cancer CT screening CAD system performance dependence on nodule size and density.
基金the National Natural Science Foundation of China(No.813716234)the National Basic Research Program(973) of China(No.2010CB834302)the Shanghai Jiao Tong University Medical Engineering Cross Research Funds(Nos.YG2013MS30 and YG2011MS51)
文摘CT colonography （CTC） is a non-invasive screening technique for the detection of eolorectal polyps, as an alternative to optical colonoscopy in clinical practice. Computer-aided detection （CAD） for CTC refers to a scheme which automatically detects colorectal polyps and masses in CT images of the colon. It has the potential to increase radiologists＇ detection performance and greatly shorten the detection time. Over the years, technical developments have advanced CAD for CTC substantially. In this paper, key techniques used in CAD for polyp detection are reviewed. Illustrations about the performance of existing CAD schemes show their relatively high sensitivity and low false positive rate. However, these CAD schemes are still suffering from technical or clinical problems. Some existing challenges faced by CAD are also pointed out at the end of this paper.
