AIM: To assess the additive effect of lubiprostone on the quality of colon preparation in diabetics given single-dosed polyethylene glycol electrolyte(PEG)for colonoscopy.METHODS:This was an investigator-initiated,sin...AIM: To assess the additive effect of lubiprostone on the quality of colon preparation in diabetics given single-dosed polyethylene glycol electrolyte(PEG)for colonoscopy.METHODS:This was an investigator-initiated,singlecenter,single-blinded prospective trial comparing the efficacy of L+PEG to PEG alone on colon preparation quality in diabetics undergoing screening colonoscopy.The study was approved by our institution’s IRB.The PEG was given as a single-dose to address patientcompliance concerns voiced by our IRB with splitdosing.All patients received only clear liquids the day prior to colonoscopy.Experimental group(Grp L)received PEG+1 dose L 2 h prior to and 2 h after PEG completion.Control group(Grp C)received only PEG the evening prior to the colonoscopy.Patients were randomly assigned to one of the 2 groups.The endoscopist was blinded to which colon prep was given and all colonoscopies were complete.Upon colonoscopy completion,the endoscopist rated the colon prep-quality by a validated 5-point Likert scale(1-excellent to 5-inadequate).RESULTS:Sixty patients were enrolled in the study;30 Grp L and 30 Grp C.Overall,patients were excluded due to study non-completion in 12(41%)Grp L and 5(17%) Grp C,P=0.04.Average colon preparation score Grp L =2.47 and Grp C=3.00,P=0.09.Although this was not statistically significant,there was a trend towards improved colon prep in Grp L.Statistical significance may have been achieved if completion rates had been similar between both study groups.CONCLUSION:Use of 2-L capsules with PEG resulted in a trend towards improved colon prep over PEG alone in diabetic patients when given as a single-dose regimen.展开更多
AIM: To investigate the impact of Jet Prep cleansing on adenoma detection rates.METHODS: In this prospective,randomized,crossover trial,patients were blindly randomized to an intervention arm or a control arm.In accor...AIM: To investigate the impact of Jet Prep cleansing on adenoma detection rates.METHODS: In this prospective,randomized,crossover trial,patients were blindly randomized to an intervention arm or a control arm.In accordance with the risk profile for the development of colorectal carcinoma,the study participants were divided into high-risk and low-risk groups.Individuals with just one criterion(age > 70 years,adenoma in medical history,and first-degree relative with colorectal cancer) were regarded as high-risk patients.Bowel preparation was performed in a standardized manner one day before the procedure.Participants in the intervention arm underwent an initial colonoscopy with standard bowel cleansing using a 250-m L syringe followed by a second colonoscopy that included irrigation by the use of the Jet Prep cleansing system.The reverse sequence was used in the control arm.The study participants were divided into a high-risk group and a low-risk group according to their respective risk profiles for the development of colorectal carcinoma.RESULTS: A total of 64 patients(34 men and 30 women) were included in the study; 22 were included in the high-risk group.After randomization,30 patients were assigned to the control group(group A) and 34 to the intervention group(group B).The average Boston Bowel Preparation Scale score was 5.15 ± 2.04.The withdrawal time needed for the first step was significantly longer in group A using the Jet Prep system(9.41 ± 3.34 min) compared to group B(7.5 ± 1.92 min).A total of 163 polyps were discovered in 64 study participants who underwent both investigation steps.In group A,49.4% of the polyps were detected during the step of standard bowel cleansing while the miss rate constituted 50.7%.Group B underwent cleansing with the Jet Prep system during the first examination step,and as many as 73.9% of polyps were identified during this step.Thus,the miss rate in group B was a mere 26.1%(P < 0.001).When considering only the right side of the colon,the miss rate in group A during the fir展开更多
基金Supported by Sucampo Pharmaceuticals,Inc.,Bethesda,Maryland and Takeda PharmaceuticalsAmerica,Inc.,Deerfield,Illinois
文摘AIM: To assess the additive effect of lubiprostone on the quality of colon preparation in diabetics given single-dosed polyethylene glycol electrolyte(PEG)for colonoscopy.METHODS:This was an investigator-initiated,singlecenter,single-blinded prospective trial comparing the efficacy of L+PEG to PEG alone on colon preparation quality in diabetics undergoing screening colonoscopy.The study was approved by our institution’s IRB.The PEG was given as a single-dose to address patientcompliance concerns voiced by our IRB with splitdosing.All patients received only clear liquids the day prior to colonoscopy.Experimental group(Grp L)received PEG+1 dose L 2 h prior to and 2 h after PEG completion.Control group(Grp C)received only PEG the evening prior to the colonoscopy.Patients were randomly assigned to one of the 2 groups.The endoscopist was blinded to which colon prep was given and all colonoscopies were complete.Upon colonoscopy completion,the endoscopist rated the colon prep-quality by a validated 5-point Likert scale(1-excellent to 5-inadequate).RESULTS:Sixty patients were enrolled in the study;30 Grp L and 30 Grp C.Overall,patients were excluded due to study non-completion in 12(41%)Grp L and 5(17%) Grp C,P=0.04.Average colon preparation score Grp L =2.47 and Grp C=3.00,P=0.09.Although this was not statistically significant,there was a trend towards improved colon prep in Grp L.Statistical significance may have been achieved if completion rates had been similar between both study groups.CONCLUSION:Use of 2-L capsules with PEG resulted in a trend towards improved colon prep over PEG alone in diabetic patients when given as a single-dose regimen.
文摘AIM: To investigate the impact of Jet Prep cleansing on adenoma detection rates.METHODS: In this prospective,randomized,crossover trial,patients were blindly randomized to an intervention arm or a control arm.In accordance with the risk profile for the development of colorectal carcinoma,the study participants were divided into high-risk and low-risk groups.Individuals with just one criterion(age > 70 years,adenoma in medical history,and first-degree relative with colorectal cancer) were regarded as high-risk patients.Bowel preparation was performed in a standardized manner one day before the procedure.Participants in the intervention arm underwent an initial colonoscopy with standard bowel cleansing using a 250-m L syringe followed by a second colonoscopy that included irrigation by the use of the Jet Prep cleansing system.The reverse sequence was used in the control arm.The study participants were divided into a high-risk group and a low-risk group according to their respective risk profiles for the development of colorectal carcinoma.RESULTS: A total of 64 patients(34 men and 30 women) were included in the study; 22 were included in the high-risk group.After randomization,30 patients were assigned to the control group(group A) and 34 to the intervention group(group B).The average Boston Bowel Preparation Scale score was 5.15 ± 2.04.The withdrawal time needed for the first step was significantly longer in group A using the Jet Prep system(9.41 ± 3.34 min) compared to group B(7.5 ± 1.92 min).A total of 163 polyps were discovered in 64 study participants who underwent both investigation steps.In group A,49.4% of the polyps were detected during the step of standard bowel cleansing while the miss rate constituted 50.7%.Group B underwent cleansing with the Jet Prep system during the first examination step,and as many as 73.9% of polyps were identified during this step.Thus,the miss rate in group B was a mere 26.1%(P < 0.001).When considering only the right side of the colon,the miss rate in group A during the fir
