目的:探讨磁振磁电治疗仪联合前列倍喜胶囊治疗慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)的有效性及安全性。方法:采用前瞻性、双中心、随机、开放、阳性药物加载、平行对照的临床设计。将124例已确诊为CP/CPPS患者按数字表法随机分为...目的:探讨磁振磁电治疗仪联合前列倍喜胶囊治疗慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)的有效性及安全性。方法:采用前瞻性、双中心、随机、开放、阳性药物加载、平行对照的临床设计。将124例已确诊为CP/CPPS患者按数字表法随机分为对照组和观察组,每组62例,对照组服用前列倍喜胶囊,观察组在服用前列倍喜胶囊基础上联合磁振磁电治疗仪理疗,疗程14 d。治疗14 d结束后,比较两组治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分及两组治疗总有效率;评估两组有效性和安全性。结果:两组治疗后的疼痛症状评分、排尿症状评分、生活质量评分及NIH-CPSI总评分均较治疗前明显改善(P<0.05);治疗后观察组的疼痛症状评分(7.34±3.26 vs 9.50±2.47)分、排尿症状评分(3.53±2.56 vs 4.50±2.35)分、生活质量评分(5.94±2.89 vs 8.03±2.60)分及总评分(16.65±7.90 vs 21.95±5.70)分均显著低于对照组,差异有统计学意义(P<0.05)。观察组临床总有效率为83.87%,明显高于对照组的53.23%,差异有统计学意义(P<0.05);治疗期间两组患者均无不良事件及不良反应发生,安全性评价为Ⅰ级。结论:磁振磁电治疗仪联合前列倍喜胶囊能显著缓解CP/CPPS患者的临床症状,疗效确切且安全性高,同时缩短治疗时间。展开更多
Background As one of the most commonly diagnosed diseases, chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） is characterized by a variety of complex symptoms. Anxiety and depression are two of the most pre...Background As one of the most commonly diagnosed diseases, chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） is characterized by a variety of complex symptoms. Anxiety and depression are two of the most prevalent clinical manifestations of patients with CP/CPPS, and have adverse effects on the health of the subjects and prognosis of comorbidities. Such psychological disorders, however, have not been deeply and thoroughly studied in China. The aim of this study was to investigate the prevalence and severity of psychological disorders in Chinese adults with CP/CPPS.Methods From April 2008 to June 2009, 80 patients and 40 age-matched healthy men participating in a voluntary health examination were recruited. The majority of the subjects completed the questionnaires on the National Institutes of Health Chronic Prostatitis Symptom Index （NIH-CPSI） as well as the hospital anxiety and depression scale （HADS）.Results Of all the participants, 77 （96.3%） patients and 37 （92.5%） healthy controls completed the questionnaires. The average NIH-CPSI total score was 21.0±9.5 for the patients and 2.2±1.5 for the controls （P=0.03）. Of the 77 patients with CP/CPPS, 48 （62.3%）, 5 （6.5%）, and 1 （1.2%） had anxiety symptoms, depression symptoms, or both anxiety and depression symptoms, respectively. For the controls, the average HADS anxiety and depression scores in patients were 14.5±6.8 and 5.2±4.5, which were both significantly higher than in controls. Moreover, the prevalence and the symptom scores of both the HADS anxiety and depression were higher for the younger age group （〈35 years） than for the older age group （〈35 years）.Conclusions This preliminary study revealed that male patients with CP/CPPS had a higher prevalence of psychological disorders than in the control subjects. Moreover, the differences of the prevalence and severity of the psychological symptoms between the two different age groups may imply that psychological disorders related to CP/CPPS may be relie展开更多
文摘目的:探讨磁振磁电治疗仪联合前列倍喜胶囊治疗慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)的有效性及安全性。方法:采用前瞻性、双中心、随机、开放、阳性药物加载、平行对照的临床设计。将124例已确诊为CP/CPPS患者按数字表法随机分为对照组和观察组,每组62例,对照组服用前列倍喜胶囊,观察组在服用前列倍喜胶囊基础上联合磁振磁电治疗仪理疗,疗程14 d。治疗14 d结束后,比较两组治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分及两组治疗总有效率;评估两组有效性和安全性。结果:两组治疗后的疼痛症状评分、排尿症状评分、生活质量评分及NIH-CPSI总评分均较治疗前明显改善(P<0.05);治疗后观察组的疼痛症状评分(7.34±3.26 vs 9.50±2.47)分、排尿症状评分(3.53±2.56 vs 4.50±2.35)分、生活质量评分(5.94±2.89 vs 8.03±2.60)分及总评分(16.65±7.90 vs 21.95±5.70)分均显著低于对照组,差异有统计学意义(P<0.05)。观察组临床总有效率为83.87%,明显高于对照组的53.23%,差异有统计学意义(P<0.05);治疗期间两组患者均无不良事件及不良反应发生,安全性评价为Ⅰ级。结论:磁振磁电治疗仪联合前列倍喜胶囊能显著缓解CP/CPPS患者的临床症状,疗效确切且安全性高,同时缩短治疗时间。
文摘Background As one of the most commonly diagnosed diseases, chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS） is characterized by a variety of complex symptoms. Anxiety and depression are two of the most prevalent clinical manifestations of patients with CP/CPPS, and have adverse effects on the health of the subjects and prognosis of comorbidities. Such psychological disorders, however, have not been deeply and thoroughly studied in China. The aim of this study was to investigate the prevalence and severity of psychological disorders in Chinese adults with CP/CPPS.Methods From April 2008 to June 2009, 80 patients and 40 age-matched healthy men participating in a voluntary health examination were recruited. The majority of the subjects completed the questionnaires on the National Institutes of Health Chronic Prostatitis Symptom Index （NIH-CPSI） as well as the hospital anxiety and depression scale （HADS）.Results Of all the participants, 77 （96.3%） patients and 37 （92.5%） healthy controls completed the questionnaires. The average NIH-CPSI total score was 21.0±9.5 for the patients and 2.2±1.5 for the controls （P=0.03）. Of the 77 patients with CP/CPPS, 48 （62.3%）, 5 （6.5%）, and 1 （1.2%） had anxiety symptoms, depression symptoms, or both anxiety and depression symptoms, respectively. For the controls, the average HADS anxiety and depression scores in patients were 14.5±6.8 and 5.2±4.5, which were both significantly higher than in controls. Moreover, the prevalence and the symptom scores of both the HADS anxiety and depression were higher for the younger age group （〈35 years） than for the older age group （〈35 years）.Conclusions This preliminary study revealed that male patients with CP/CPPS had a higher prevalence of psychological disorders than in the control subjects. Moreover, the differences of the prevalence and severity of the psychological symptoms between the two different age groups may imply that psychological disorders related to CP/CPPS may be relie
