Four strains of microorganisms which have activity of chloroacetophenone reduction were screened, in which Saccharomyces cerevisiae B5 showed the highest activity and good stereoselectivity. This strains showed differ...Four strains of microorganisms which have activity of chloroacetophenone reduction were screened, in which Saccharomyces cerevisiae B5 showed the highest activity and good stereoselectivity. This strains showed different activity on the reduction of various substrates in the following order: 2′-chloroacetophenone > 2-chloromethylacetophenone > 4′-chloroacetophenone > 3′-chloroacetophenone > acetophenone. Ethanol is the best cosubstrate and its optimal concentration is 5%.展开更多
4-（4-Bromobutyl）styrene was synthesized from p-chloroacetophenone. p-Chloroacetophenone was hydrogenized with potassium hydrogenborane to obtain p-chlorophenylethanol, which was then dehydrated to yield p-chlorostyr...4-（4-Bromobutyl）styrene was synthesized from p-chloroacetophenone. p-Chloroacetophenone was hydrogenized with potassium hydrogenborane to obtain p-chlorophenylethanol, which was then dehydrated to yield p-chlorostyrene in the presence of potassium bisulfate, and finally p-chlorostyrene was reacted with （magnesium） to get Grignard reagent, which was then reacted with 1,4-dibromobutane to synthesize 4-（4-（bromobutyl））styrene. MS, 1H NMR and FT-IR were used to characterize the product. The results are （consistent） with the structure of 4-（4-bromobutyl） styrene.展开更多
This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin–Westreaction for the synthesis of b-acetamido ketones. The method has several advantages such asrequiring only mild conditions and a low c...This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin–Westreaction for the synthesis of b-acetamido ketones. The method has several advantages such asrequiring only mild conditions and a low concentration of catalyst. Screening of 19 b-acetamidoketones for antidiabetic activity in vitro showed that their activity as peroxisome proliferatoractivated receptor (PPAR) agonists and as dipeptidyl peptidase 4 (DPP-IV) inhibitors wasfairly weak.展开更多
文摘Four strains of microorganisms which have activity of chloroacetophenone reduction were screened, in which Saccharomyces cerevisiae B5 showed the highest activity and good stereoselectivity. This strains showed different activity on the reduction of various substrates in the following order: 2′-chloroacetophenone > 2-chloromethylacetophenone > 4′-chloroacetophenone > 3′-chloroacetophenone > acetophenone. Ethanol is the best cosubstrate and its optimal concentration is 5%.
文摘4-（4-Bromobutyl）styrene was synthesized from p-chloroacetophenone. p-Chloroacetophenone was hydrogenized with potassium hydrogenborane to obtain p-chlorophenylethanol, which was then dehydrated to yield p-chlorostyrene in the presence of potassium bisulfate, and finally p-chlorostyrene was reacted with （magnesium） to get Grignard reagent, which was then reacted with 1,4-dibromobutane to synthesize 4-（4-（bromobutyl））styrene. MS, 1H NMR and FT-IR were used to characterize the product. The results are （consistent） with the structure of 4-（4-bromobutyl） styrene.
基金This project is supported by "The Fundamental Research Funds for the Central Universities"(XDJK2010C067).
文摘This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin–Westreaction for the synthesis of b-acetamido ketones. The method has several advantages such asrequiring only mild conditions and a low concentration of catalyst. Screening of 19 b-acetamidoketones for antidiabetic activity in vitro showed that their activity as peroxisome proliferatoractivated receptor (PPAR) agonists and as dipeptidyl peptidase 4 (DPP-IV) inhibitors wasfairly weak.
