Colorectal cancer is one of the most common malignant tumors worldwide. A model of cancer development involving cancer stem cells has been put forward because it provides a possible explanation of tumor hierarchy. Can...Colorectal cancer is one of the most common malignant tumors worldwide. A model of cancer development involving cancer stem cells has been put forward because it provides a possible explanation of tumor hierarchy. Cancer stem cells are characterized by their proliferation, tumorigenesis, differentiation, and selfrenewal capacities, and chemoradiotherapy resistance. Due to the role of cancer stem cells in tumor initiation and treatment failure, studies of cancer stem cell markers, such as CD133, have been of great interest. CD133, a five-transmembrane glycoprotein, is widely used as a marker to identify and isolate colorectal cancer stem cells. This marker has been investigated to better understand the characteristics and functions of cancer stem cells. Moreover, it can also be used to predict tumor progression, patient survival, chemoradiotherapy resistance and other clinical parameters. In this review, we discuss the use of CD133 in the identification of colorectal cancer stem cell, which is currently controversial. Although the function of CD133 is as yet unclear, we have discussed several possible functions and associated mechanisms that may partially explain the role of CD133 in colorectal cancers. In addition, we focus on the prognostic value of CD133 in colorectal cancers. Finally, we predict that CD133 may be used as a possible target for colorectal cancer treatment.展开更多
胰腺癌是恶性程度极高的消化道肿瘤,是全球癌症相关性死亡的主要原因之一。由于发病机制尚不明确,早期缺乏特征性临床表现及诊断方法,且传统治疗效果欠佳,导致胰腺癌的发病率及死亡率居高不下。近年来,随着干细胞在多个领域研究的不断推...胰腺癌是恶性程度极高的消化道肿瘤,是全球癌症相关性死亡的主要原因之一。由于发病机制尚不明确,早期缺乏特征性临床表现及诊断方法,且传统治疗效果欠佳,导致胰腺癌的发病率及死亡率居高不下。近年来,随着干细胞在多个领域研究的不断推进,胰腺癌干细胞(pancreatic cancer stem cells,PCSCs)在胰腺癌发生发展中的作用越来越受到重视。本文着重介绍了PCSCs的可塑性及能量代谢特点,以及在胰腺癌耐药、转移中的作用和机制,并总结了干细胞作为治疗靶点的相关进展。展开更多
基金Supported by Clinical Key Discipline Fund by Ministry of Health(2010-2012)Chinese National Clinical Key Discipline(2011-2012)the Shanghai Science and Technology Commission of Shanghai Municipality,No.10DJ1400500
文摘Colorectal cancer is one of the most common malignant tumors worldwide. A model of cancer development involving cancer stem cells has been put forward because it provides a possible explanation of tumor hierarchy. Cancer stem cells are characterized by their proliferation, tumorigenesis, differentiation, and selfrenewal capacities, and chemoradiotherapy resistance. Due to the role of cancer stem cells in tumor initiation and treatment failure, studies of cancer stem cell markers, such as CD133, have been of great interest. CD133, a five-transmembrane glycoprotein, is widely used as a marker to identify and isolate colorectal cancer stem cells. This marker has been investigated to better understand the characteristics and functions of cancer stem cells. Moreover, it can also be used to predict tumor progression, patient survival, chemoradiotherapy resistance and other clinical parameters. In this review, we discuss the use of CD133 in the identification of colorectal cancer stem cell, which is currently controversial. Although the function of CD133 is as yet unclear, we have discussed several possible functions and associated mechanisms that may partially explain the role of CD133 in colorectal cancers. In addition, we focus on the prognostic value of CD133 in colorectal cancers. Finally, we predict that CD133 may be used as a possible target for colorectal cancer treatment.
文摘胰腺癌是恶性程度极高的消化道肿瘤,是全球癌症相关性死亡的主要原因之一。由于发病机制尚不明确,早期缺乏特征性临床表现及诊断方法,且传统治疗效果欠佳,导致胰腺癌的发病率及死亡率居高不下。近年来,随着干细胞在多个领域研究的不断推进,胰腺癌干细胞(pancreatic cancer stem cells,PCSCs)在胰腺癌发生发展中的作用越来越受到重视。本文着重介绍了PCSCs的可塑性及能量代谢特点,以及在胰腺癌耐药、转移中的作用和机制,并总结了干细胞作为治疗靶点的相关进展。
