摘要
肿瘤微环境(tumor microenvironment,TME)是肿瘤细胞赖以生存的基石,其独特的缺氧、免疫抑制、代谢及机械力学环境不仅为肿瘤进展提供合适的物化“土壤”,同时在肿瘤放化疗抵抗中也发挥重要作用.本文归纳总结了缺氧、免疫抑制、代谢异常和基质硬度参与消化系统肿瘤放化疗抵抗最新研究进展,同时对靶向力学微环境逆转肿瘤放化疗抵抗新策略进行了探讨,阐明肿瘤微环境物化特征改变在肿瘤药物抵抗中的重要作用.
Tumor microenvironment(TME)is the cornerstone of the survival of tumor cells.It generally presents unique physical and chemical characteristics such as hypoxia,immunosuppression,metabolic reprogramming,and matrix stiffening,which not only offer suitable soil to support tumorigenesis and progression,but also resist the effects of radiotherapy and chemotherapy.Here,we summarize new progress in the mechanism of hypoxia,immunosuppression,metabolic reprogramming,and matrix stiffness-driven chemoradiotherapy resistance in digestive system tumors,and discuss the new intervention strategy against matrix stiffness-driven chemoradiotherapy resistance,which underlines the contribution of physical and chemical characteristics of tumor microenvironment in drug resistance.
作者
赵莹莹
王咪咪
崔杰峰
Ying-Ying Zhao;Mi-Mi Wang;Jie-Feng Cui(Liver Cancer Institute,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《世界华人消化杂志》
CAS
2022年第8期341-348,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目,No.81972910.
关键词
肿瘤微环境
消化系统肿瘤
放化疗抵抗
Tumor microenvironment
Digestive system tumors
Chemoradiotherapy resistance
