Background Enamel decalcification in orthodontics is a concern for dentists and methods to remineralize these lesions are the focus of intense research. The aim of this study was to evaluate the remineralizing effect ...Background Enamel decalcification in orthodontics is a concern for dentists and methods to remineralize these lesions are the focus of intense research. The aim of this study was to evaluate the remineralizing effect of casein phosphopeptide amorphous calcium phosphate （CPP-ACP） nanocomplexes on enamel decalcification in orthodontics. Methods Twenty orthodontic patients with decalcified enamel lesions during fixed orthodontic therapy were recruited to this study as test group and twenty orthodontic patients with the similar condition as control group. GC Tooth Mousse, the main component of which is CPP-ACP, was used by each patient of test group every night after tooth-brushing for six months. For control group, each patient was asked to brush teeth with toothpaste containing 1100 parts per million （ppm） of fluoride twice a day. Standardized intraoral images were taken for all patients and the extent of enamel decalcification was evaluated before and after treatment over this study period. Measurements were statistically compared by t test. Results After using CPP-ACP for six months, the enamel decalcification index （EDI） of all patients had decreased; the mean EDI before using CPP-ACP was 0.191＋0.025 and that after using CPP-ACP was 0.183＋0.023, the difference was significant （t=5.169, P 〈0.01）. For control group, the mean EDI before treatment was 0.188±0.037 and that after treatment was 0.187±0.046, the difference was not significant （t=1.711, P 〉0.05）. Conclusion CPP-ACP can effectively improve the demineralized enamel lesions during orthodontic treatment, so it has some remineralization potential for enamel decalcification in orthodontics.展开更多
目的 通过合成纳米羟基磷灰石（hydroxyapatite，HA）以及体外实验观察其对牙本质小管的封闭效果，为纳米HA的临床应用提供依据。方法采用磷酸氢二铵[（NH4）2HPO4]和硝酸钙[Ca（NO3）2]合成纳米HA，扫描电子显微镜（scanning electron ...目的 通过合成纳米羟基磷灰石（hydroxyapatite，HA）以及体外实验观察其对牙本质小管的封闭效果，为纳米HA的临床应用提供依据。方法采用磷酸氢二铵[（NH4）2HPO4]和硝酸钙[Ca（NO3）2]合成纳米HA，扫描电子显微镜（scanning electron microscope，SEM）、透射电子显微镜（transmission electron microscope，TEM）、傅里叶变换红外光谱计（Fourier transform infrared spectrometer，FTIR）和X射线衍射仪（X—ray diffractometer，XRD）检测纳米HA。选取8颗健康第三磨牙制备24片牙本质薄片，按随机数字表分为酪蛋白磷酸肽钙磷复合体（casein phosphopeptideamorphous calciumphosphate，CPP—ACP）组、纳米HA组及空白对照组，每组8片；空白对照组不做处理，CPP—ACP组和纳米HA组每天分别用CPP-ACP和纳米HA处理牙本质薄片2次，7d后SEM观察牙本质表面。结果经SEM、TEM、FTIR和XRD检测，证实本项实验制备的HA为纳米HA；SEM观察纳米HA对牙本质小管的封闭效果明显高于CPP—ACP组和空白对照组。结论在体外条件下，与CPP—ACP相比，纳米HA可更有效地封闭暴露的牙本质小管。展开更多
文摘Background Enamel decalcification in orthodontics is a concern for dentists and methods to remineralize these lesions are the focus of intense research. The aim of this study was to evaluate the remineralizing effect of casein phosphopeptide amorphous calcium phosphate （CPP-ACP） nanocomplexes on enamel decalcification in orthodontics. Methods Twenty orthodontic patients with decalcified enamel lesions during fixed orthodontic therapy were recruited to this study as test group and twenty orthodontic patients with the similar condition as control group. GC Tooth Mousse, the main component of which is CPP-ACP, was used by each patient of test group every night after tooth-brushing for six months. For control group, each patient was asked to brush teeth with toothpaste containing 1100 parts per million （ppm） of fluoride twice a day. Standardized intraoral images were taken for all patients and the extent of enamel decalcification was evaluated before and after treatment over this study period. Measurements were statistically compared by t test. Results After using CPP-ACP for six months, the enamel decalcification index （EDI） of all patients had decreased; the mean EDI before using CPP-ACP was 0.191＋0.025 and that after using CPP-ACP was 0.183＋0.023, the difference was significant （t=5.169, P 〈0.01）. For control group, the mean EDI before treatment was 0.188±0.037 and that after treatment was 0.187±0.046, the difference was not significant （t=1.711, P 〉0.05）. Conclusion CPP-ACP can effectively improve the demineralized enamel lesions during orthodontic treatment, so it has some remineralization potential for enamel decalcification in orthodontics.
