AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated cirrhosis.METHODS: Four patients with decompensated...AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated cirrhosis.METHODS: Four patients with decompensated cirrhosis were included. Approximately 200 mL of the bone marrow of the patients was aspirated, and CD34+ stem cells were selected. Between 3 to 10 million CD34+ cells were isolated. The cells were slowly infused through the hepatic artery of the patients.RESULTS: Patient 1 showed marginal improvement in serum albumin and no significant changes in other test results. In patient 2 prothrombin time was decreased; however, her total bilirubin, serum creatinine, and Model of End-Stage Liver Disease (MELD) score worsened at the end of follow up. In patient 3 there was improvement in serum albumin, porthrombin time (PT), and MELD score. Patient 4 developed radiocontrast nephropathy after the procedure, and progressed to type 1 hepatorenal syndrome and died of liver failure a few days later. Because of the major side effects seen in the last patient, the trial was prematurely stopped.CONCLUSION: Infusion of CD34+ stem cells through the hepatic artery is not safe in decompensated cirrhosis. Radiocontrast nephropathy and hepatorenal syndrome could be major side effects. However, this study doesnot preclude infusion of CD34+ stem cells through other routes.展开更多
骨矿密度(bone mineral density,BMD)一直是评价骨质疏松及骨折风险的重要指标。近年来,研究表明骨质量是骨折风险的一项重要因素。一般认为骨质量与骨矿质和有机质成分、骨微结构、骨重建及其更新率、骨内微损伤的累积和自我修复等因...骨矿密度(bone mineral density,BMD)一直是评价骨质疏松及骨折风险的重要指标。近年来,研究表明骨质量是骨折风险的一项重要因素。一般认为骨质量与骨矿质和有机质成分、骨微结构、骨重建及其更新率、骨内微损伤的累积和自我修复等因素有关。骨质量的检测包括骨代谢标志物的检测以及影像学方法对BMD和骨微结构的检测。对骨质量概念及其检测技术研究的不断深入对骨折风险评价、骨质疏松的诊断及疗效评价有着重要意义。文中就影响骨质量的因素及其检测方法作一综述。展开更多
文摘AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated cirrhosis.METHODS: Four patients with decompensated cirrhosis were included. Approximately 200 mL of the bone marrow of the patients was aspirated, and CD34+ stem cells were selected. Between 3 to 10 million CD34+ cells were isolated. The cells were slowly infused through the hepatic artery of the patients.RESULTS: Patient 1 showed marginal improvement in serum albumin and no significant changes in other test results. In patient 2 prothrombin time was decreased; however, her total bilirubin, serum creatinine, and Model of End-Stage Liver Disease (MELD) score worsened at the end of follow up. In patient 3 there was improvement in serum albumin, porthrombin time (PT), and MELD score. Patient 4 developed radiocontrast nephropathy after the procedure, and progressed to type 1 hepatorenal syndrome and died of liver failure a few days later. Because of the major side effects seen in the last patient, the trial was prematurely stopped.CONCLUSION: Infusion of CD34+ stem cells through the hepatic artery is not safe in decompensated cirrhosis. Radiocontrast nephropathy and hepatorenal syndrome could be major side effects. However, this study doesnot preclude infusion of CD34+ stem cells through other routes.
文摘骨矿密度(bone mineral density,BMD)一直是评价骨质疏松及骨折风险的重要指标。近年来,研究表明骨质量是骨折风险的一项重要因素。一般认为骨质量与骨矿质和有机质成分、骨微结构、骨重建及其更新率、骨内微损伤的累积和自我修复等因素有关。骨质量的检测包括骨代谢标志物的检测以及影像学方法对BMD和骨微结构的检测。对骨质量概念及其检测技术研究的不断深入对骨折风险评价、骨质疏松的诊断及疗效评价有着重要意义。文中就影响骨质量的因素及其检测方法作一综述。
文摘目的了解恶性骨肿瘤患者希望水平、人格特征及生活质量现状,并探讨患者希望水平和人格特征与生活质量的相关性。方法应用Herth希望量表(Herth hope index,HHI)、艾森克人格问卷简式量表(Eysenck personality questionnaire,EPQ)及生活质量核心问卷(quality of life questionnaire-core 30,QLQ-C30)对160例恶性骨肿瘤患者进行调查。恶性骨肿瘤患者希望水平和人格特征与生活质量的影响采用Pearson相关分析。结果本组恶性骨肿瘤患者整体生活质量量表得分为(57.05±20.09)分,HHI总分(32.88±4.05)分,EPQ量表中的内外向、神经质、精神病质、掩饰倾向得分分别为(54.05±12.29)分、(50.97±11.07)分、(49.14±20.07)分、(52.75±9.01)分。患者希望水平与生活质量呈正相关(P<0.05)。患者人格的内外向和掩饰倾向与其生活质量均呈正相关;患者人格的神经质和精神病质与其生活质量均呈负相关(P<0.05)。结论恶性骨肿瘤患者生活质量较差,护士应根据患者的希望水平及人格特征采取针对性干预策略,以提高其生活质量和心身健康状况。
