目的探究老年脑小血管病(cerebral small vessel disease,CSVD)患者音乐感知能力的特点。方法2019年1月~9月在解放军总医院第七医学中心神经内科就诊的老年脑白质损害患者35例(CSVD组),另选择年龄与性别与之匹配的健康体检者32例(对照...目的探究老年脑小血管病(cerebral small vessel disease,CSVD)患者音乐感知能力的特点。方法2019年1月~9月在解放军总医院第七医学中心神经内科就诊的老年脑白质损害患者35例(CSVD组),另选择年龄与性别与之匹配的健康体检者32例(对照组),利用蒙特利尔失歌症成套测验(Montreal Battery of Evaluation of Amusia,MBEA)测评被试包括音高、节奏、记忆在内的音乐感知能力。同时收集人口学资料及认知功能测评数据。采用Pearson相关分析统计音乐感知能力得分与其他指标的相关性。结果CSVD组在音高、节奏、记忆以及总得分上均明显低于对照组(P<0.05)。相关性分析显示,节奏得分主要与DSST相关(r=-0.374,P=0.002);记忆得分主要与DSST(r=-0.278,P=0.023)和CRT(r=0.323,P=0.008)相关;总得分主要与DSST(r=-0.338,P=0.005)和CRT(r=0.247,P=0.044)相关。结论音乐感知能力测评显示,老年CSVD患者与健康体检者有明显差异,有助于发现老年CSVD患者在执行功能方面存在的损害。展开更多
Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little...Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little attention has been paid to the changes in the motor rain within congenital amusia.In this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group.We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network.We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores.In conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia.Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination.The study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(No.WDX20180101GZ01)on February 9,2019.展开更多
文摘目的探究老年脑小血管病(cerebral small vessel disease,CSVD)患者音乐感知能力的特点。方法2019年1月~9月在解放军总医院第七医学中心神经内科就诊的老年脑白质损害患者35例(CSVD组),另选择年龄与性别与之匹配的健康体检者32例(对照组),利用蒙特利尔失歌症成套测验(Montreal Battery of Evaluation of Amusia,MBEA)测评被试包括音高、节奏、记忆在内的音乐感知能力。同时收集人口学资料及认知功能测评数据。采用Pearson相关分析统计音乐感知能力得分与其他指标的相关性。结果CSVD组在音高、节奏、记忆以及总得分上均明显低于对照组(P<0.05)。相关性分析显示,节奏得分主要与DSST相关(r=-0.374,P=0.002);记忆得分主要与DSST(r=-0.278,P=0.023)和CRT(r=0.323,P=0.008)相关;总得分主要与DSST(r=-0.338,P=0.005)和CRT(r=0.247,P=0.044)相关。结论音乐感知能力测评显示,老年CSVD患者与健康体检者有明显差异,有助于发现老年CSVD患者在执行功能方面存在的损害。
基金supported by the National Natural Science Foundation of China,No.81771172(to DXW),81671671(to JL)the Second Xiangya Hospital Start-Up Fund,China。
文摘Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little attention has been paid to the changes in the motor rain within congenital amusia.In this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group.We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network.We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores.In conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia.Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination.The study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(No.WDX20180101GZ01)on February 9,2019.
