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Enantioselective synthesis of β-amino esters bearing a quinazoline moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative
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《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2013年第3期321-328,共8页
The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isol... The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isolated with high enantiomeric excess (up to 99%). 展开更多
关键词 Cinchona alkaloid-based thiourea Mannich reaction p-amino esters enantioselective synthesis
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