Purpose The aim of this study was to investigate the prevalence of the ACTN3 rs1815739 polymorphism and to study its association with athletes'level of competition and lower-extremity power.Method Time-of-flight m...Purpose The aim of this study was to investigate the prevalence of the ACTN3 rs1815739 polymorphism and to study its association with athletes'level of competition and lower-extremity power.Method Time-of-flight mass spectrometry(TOFMS)and polymerase chain reaction-restriction fragment length polymor-phism(PCR-RFLP)techniques were employed to identify the ACTN3 rs1815739 genotypes and allele frequencies in 108 elite sprinters and 206 untrained controls.Questionnaires were then used to assess subjects'100 m sprint,standing jump(SJ)and standing triple jump(STJ)personal best record.Results(1)The RR,RX and XX genotype distribution of the ACTN3 rs1815739 polymorphism is 42.6%,49.1%,8.3%,respectively.R and X alleles frequency is 67.1%and 32.9%,respectively,which comply with Hardy Weinberg equilibrium(HWE)through Chi-square(x2)tests(x2=0.661;df=2;P=0.718).(2)Significant differences were found in R allele fre-quency between the elite sprinter group and controls.(3)The athletes'100 m sprint,SJ,and STJ personal best records were better in those with RR and RX than XX genotype.A significant association was observed between the R alleles and 100 m sprint,SJ,and STJ results of male and female athletes.Conclusion The present results indicate that ACTN3 rs1815739 polymorphism has a significant association with speed and lower-extremity power in sprint/power athletes.展开更多
Purpose:The aim of this study was to review,systematically,evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in ath...Purpose:The aim of this study was to review,systematically,evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training programs.Methods:A computerized literature search was performed in the electronic databases PubMed,Web of Science,and SPORTDiscus,from inception until November 2020.All included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the ACTN3 R577X polymorphism.Results:Our search identified 492 records.After the screening of titles,abstracts,and full texts,13 studies examining the association between the ACTN3 genotypes and the rate and severity of non-contact injury were included in the analysis.These studies were performed in 6 different countries(Spain,Japan,Brazil,China,the Republic of Korea,and Italy)and involved a total participant pool of 1093 participants.Of the studies,2 studies involved only women,5 studies involved only men,and 6 studies involved both men and women.All the studies included were classified as highquality studies(≥6 points in the Physiotherapy Evidence Database(PEDro)scale score).Overall,evidence suggests there is an association between the ACTN3 R577X genotype and non-contact injury in 12 investigations.Six studies observed a significant association between A CTN3 R577X polymorphism and exercise induced muscle damage:2 with non-contact ankle injury,3 with non-contact muscle injury,and 1 with overall non-contact injury.Conclusion:The present findings support the premise that possessing the ACTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries,such as muscle injury,ankle sprains,and higher levels of exercise-induced muscle damage.展开更多
基金supported by Fundamental Research Funds for the Central Universities under Grant 2017SYS001.
文摘Purpose The aim of this study was to investigate the prevalence of the ACTN3 rs1815739 polymorphism and to study its association with athletes'level of competition and lower-extremity power.Method Time-of-flight mass spectrometry(TOFMS)and polymerase chain reaction-restriction fragment length polymor-phism(PCR-RFLP)techniques were employed to identify the ACTN3 rs1815739 genotypes and allele frequencies in 108 elite sprinters and 206 untrained controls.Questionnaires were then used to assess subjects'100 m sprint,standing jump(SJ)and standing triple jump(STJ)personal best record.Results(1)The RR,RX and XX genotype distribution of the ACTN3 rs1815739 polymorphism is 42.6%,49.1%,8.3%,respectively.R and X alleles frequency is 67.1%and 32.9%,respectively,which comply with Hardy Weinberg equilibrium(HWE)through Chi-square(x2)tests(x2=0.661;df=2;P=0.718).(2)Significant differences were found in R allele fre-quency between the elite sprinter group and controls.(3)The athletes'100 m sprint,SJ,and STJ personal best records were better in those with RR and RX than XX genotype.A significant association was observed between the R alleles and 100 m sprint,SJ,and STJ results of male and female athletes.Conclusion The present results indicate that ACTN3 rs1815739 polymorphism has a significant association with speed and lower-extremity power in sprint/power athletes.
文摘Purpose:The aim of this study was to review,systematically,evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training programs.Methods:A computerized literature search was performed in the electronic databases PubMed,Web of Science,and SPORTDiscus,from inception until November 2020.All included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the ACTN3 R577X polymorphism.Results:Our search identified 492 records.After the screening of titles,abstracts,and full texts,13 studies examining the association between the ACTN3 genotypes and the rate and severity of non-contact injury were included in the analysis.These studies were performed in 6 different countries(Spain,Japan,Brazil,China,the Republic of Korea,and Italy)and involved a total participant pool of 1093 participants.Of the studies,2 studies involved only women,5 studies involved only men,and 6 studies involved both men and women.All the studies included were classified as highquality studies(≥6 points in the Physiotherapy Evidence Database(PEDro)scale score).Overall,evidence suggests there is an association between the ACTN3 R577X genotype and non-contact injury in 12 investigations.Six studies observed a significant association between A CTN3 R577X polymorphism and exercise induced muscle damage:2 with non-contact ankle injury,3 with non-contact muscle injury,and 1 with overall non-contact injury.Conclusion:The present findings support the premise that possessing the ACTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries,such as muscle injury,ankle sprains,and higher levels of exercise-induced muscle damage.
