progeria syndrome （HGPS） and Wemer syndrome （WS） are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A （LMNA） gene, resulting in the production of a truncated...progeria syndrome （HGPS） and Wemer syndrome （WS） are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A （LMNA） gene, resulting in the production of a truncated protein product-progerin. WS is caused by mutations in 14/RN gem）, encoding a loss-of-function RecQ DNA helicase. Here, by gene editing we created isogenic human embryonic stem cells （ESCs） with heterozygous （G608G/＋） or homozygous （G608G/G608G） LMNA mutation and biallelic WRN knockout, for modeling HGPS and WS pathogenesis, respectively. While ESCs and endothelial cells （ECs） did not present any features of premature senescence, HGPS- and WS-mesenchymal stem cells （MSCs） showed aging-associated phenotypes with different kinetics. WS-MSCs had early-onset mild premature aging phenotypes while HGPS-MSCs exhibited iate-onset acute premature aging characterisitcs. Taken together, our study compares and contrasts the distinct pathologies underpinning the two premature aging disorders, and provides reliable stem-cell based models to identify new therapeutic strategies for pathological and physiological aging.展开更多
Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for ge...Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders.展开更多
Quantum entanglement, a key resource in quantum information processing, is reduced by interaction between the quantum system concerned and its unavoidable noisy environment. Therefore it is of particular importance to...Quantum entanglement, a key resource in quantum information processing, is reduced by interaction between the quantum system concerned and its unavoidable noisy environment. Therefore it is of particular importance to study the dynamical properties of entanglement in open quantum systems. In this work, we mainly focus on two qubits coupled to an adjustable environment, namely a semi-infinite transmission line. The two qubits' relaxations, through individual channels or collective channel or both, can be adjusted by the qubits' transition frequencies. We examine entanglement dynamics in this model system with initial Werner state, and show that the phenomena of entanglement sudden death and revival can be observed. Due to the hardness of preparing the Werner state experimentally, we introduce a new type of entangled state called pseudo-Werner state, which preserves as much entangling property as the Werner state, and more importantly,it is experiment friendly. Furthermore, we provide detailed procedures for generating pseudo-Werner state and studying entanglement dynamics with it, which can be straightforwardly implemented in a superconducting waveguide quantum electrodynamics system.展开更多
In this paper we discuss two measures for the quantumness of correlations (quantum discord and entanglement) of two isolated moving atoms which are initially in Werner state. We compare and analyze the effect of the a...In this paper we discuss two measures for the quantumness of correlations (quantum discord and entanglement) of two isolated moving atoms which are initially in Werner state. We compare and analyze the effect of the atomic motion in quantum discord and entanglement. The results show that the atomic motion related to the field mode structure parameter can make the entanglement and quantum discord evolve periodically. The results also indicate that the entanglement suddenly disappears during the evaluation but quantum discord remains non zero, so quantum discord is considered as indicator of disentanglement.展开更多
Werner Herzog is a rebellious artist and lonely dreamer.Throughout his whole career, Herzog enthusiastically and persistently pursues cinematic dream, courting disasters and overcoming the seemingly insurmountable. Th...Werner Herzog is a rebellious artist and lonely dreamer.Throughout his whole career, Herzog enthusiastically and persistently pursues cinematic dream, courting disasters and overcoming the seemingly insurmountable. This paper argues that Stroszek reflects Herzog's rebellious spirit and dream passion in its combination of the documentary with fiction, ecstatic truth and heroic characters.展开更多
Many previous studies about teleportation are based on pure state. Study of quantum channel as mixed state is more realistic but complicated as pure states degenerate into mixed states by interaction with environment,...Many previous studies about teleportation are based on pure state. Study of quantum channel as mixed state is more realistic but complicated as pure states degenerate into mixed states by interaction with environment, and the Werner state plays an important role in the study of the mixed state. In this paper, the quantum wireless multihop network is proposed and the information is transmitted hop by hop through teleportation. We deduce a specific expression of the recovered state not only after one-hop teleportation but also across multiple intermediate nodes based on Werner state in a quantum wireless multihop network. We also obtain the fidelity of multihop teleportation.展开更多
In this note,we give a new lower bound for the concurrence,which is related to D-concurrence.For the Werner states,we compare that this D-concurrence bound with the other known bound.In addition,some of new upper and ...In this note,we give a new lower bound for the concurrence,which is related to D-concurrence.For the Werner states,we compare that this D-concurrence bound with the other known bound.In addition,some of new upper and lower bounds of D-concurrence are given.展开更多
In this article,we introduce a framework for entanglement quantification of photon pairs represented by two-qubit Werner states.The measurement scheme is based on the symmetric informationally complete POVM.To make th...In this article,we introduce a framework for entanglement quantification of photon pairs represented by two-qubit Werner states.The measurement scheme is based on the symmetric informationally complete POVM.To make the framework realistic,we impose the Poisson noise on the measured two-photon coincidences.For various settings,numerical simulations were performed to evaluate the efficiency of the framework.展开更多
The grisly 1937 murder of 19-year-old Pamela Werner was first "solved" by Paul French's award-winning Midnight in Peking. Published in 2011, French's book was a minor sensation, a lurid rickshaw ride...The grisly 1937 murder of 19-year-old Pamela Werner was first "solved" by Paul French's award-winning Midnight in Peking. Published in 2011, French's book was a minor sensation, a lurid rickshaw ride through the fetid nether regions of Beijing society. Now a rival publication by fellow Brit and former policeman Graeme Sheppard claims to overturn that rickshaw and set the record straight.展开更多
Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatricdiseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development ...Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatricdiseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development ofcardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become thefocus in aging research. Natural aging is not regarded as a programmed process. However, accelerated agingdue to inherited genetic defects in patients of progeria is programmed and resembles many aspects ofnatural aging. Among several premature aging syndromes, Werner syndrome (WS) and Hutchinson–Gilfordprogeria syndrome (HGPS) are two broadly investigated diseases. In this review, we discuss how stem cellaging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigeneticlandscape in aged cells can be reversed to a “juvenile” state. Lastly, we explore the potential application ofthe latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.展开更多
Samuel Warren Carey(塔斯玛尼亚大学地质学荣誉教授)是一位著名的以地球膨胀理论代替板块构造理论的积极倡导者。由于他77岁时的最新杰作是以“有知识的外行而不是技术专家”的演说形式发表的,因此,遗憾的是这篇杰作不能在参考文献和...Samuel Warren Carey(塔斯玛尼亚大学地质学荣誉教授)是一位著名的以地球膨胀理论代替板块构造理论的积极倡导者。由于他77岁时的最新杰作是以“有知识的外行而不是技术专家”的演说形式发表的,因此,遗憾的是这篇杰作不能在参考文献和资料中得以存在的原因。这本书的精华就在于有许多我们当中的人不同意的观点,所以我们应该阅读一下。展开更多
文摘progeria syndrome （HGPS） and Wemer syndrome （WS） are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A （LMNA） gene, resulting in the production of a truncated protein product-progerin. WS is caused by mutations in 14/RN gem）, encoding a loss-of-function RecQ DNA helicase. Here, by gene editing we created isogenic human embryonic stem cells （ESCs） with heterozygous （G608G/＋） or homozygous （G608G/G608G） LMNA mutation and biallelic WRN knockout, for modeling HGPS and WS pathogenesis, respectively. While ESCs and endothelial cells （ECs） did not present any features of premature senescence, HGPS- and WS-mesenchymal stem cells （MSCs） showed aging-associated phenotypes with different kinetics. WS-MSCs had early-onset mild premature aging phenotypes while HGPS-MSCs exhibited iate-onset acute premature aging characterisitcs. Taken together, our study compares and contrasts the distinct pathologies underpinning the two premature aging disorders, and provides reliable stem-cell based models to identify new therapeutic strategies for pathological and physiological aging.
基金supported by the National Key Research and Development Program of China(2017YFA0103304)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010100)+5 种基金the National Key Research and Development Program of China(2015CB964800,2017YFA0102802,2014CB910503 and 2018YFA0107203)the National High Tech no logy Research and Development Program of China(2015AA020307)the National Natural Science Foundation of China(Grant Nos.31671429,91749202,91749123,81625009,81330008,81371342,81471414,81422017,81601233,81671377,31601109,31601158,81771515 and 81701388)Program of Beijing Municipal Science and Technology Commission(Z151100003 915072)Key Research Program of the Chinese Academy of Sciences(KJZDEW-TZ-L05),Beijing Municipal Commission of Health and Family Planning(PXM2018_026283_000002)Advanced Innovation Center for Human Brain Protection(117212).
文摘Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders.
基金Project supported by the Key-Area Research and Development Program of Guangdong Province of China (Grant No. 2018B030326001)the National Natural Science Foundation of China (Grant No. 11874065)+2 种基金the Guangdong Provincial Key Laboratory (Grant No. 2019B121203002)the Science, Technology and Innovation Commission of Shenzhen Municipality (Grant No. KYTDPT20181011104202253)the Shenzhen Hong Kong Cooperation Zone for Technology and Innovation of China (Grant No. HZQB-KCZYB2020050)。
文摘Quantum entanglement, a key resource in quantum information processing, is reduced by interaction between the quantum system concerned and its unavoidable noisy environment. Therefore it is of particular importance to study the dynamical properties of entanglement in open quantum systems. In this work, we mainly focus on two qubits coupled to an adjustable environment, namely a semi-infinite transmission line. The two qubits' relaxations, through individual channels or collective channel or both, can be adjusted by the qubits' transition frequencies. We examine entanglement dynamics in this model system with initial Werner state, and show that the phenomena of entanglement sudden death and revival can be observed. Due to the hardness of preparing the Werner state experimentally, we introduce a new type of entangled state called pseudo-Werner state, which preserves as much entangling property as the Werner state, and more importantly,it is experiment friendly. Furthermore, we provide detailed procedures for generating pseudo-Werner state and studying entanglement dynamics with it, which can be straightforwardly implemented in a superconducting waveguide quantum electrodynamics system.
文摘In this paper we discuss two measures for the quantumness of correlations (quantum discord and entanglement) of two isolated moving atoms which are initially in Werner state. We compare and analyze the effect of the atomic motion in quantum discord and entanglement. The results show that the atomic motion related to the field mode structure parameter can make the entanglement and quantum discord evolve periodically. The results also indicate that the entanglement suddenly disappears during the evaluation but quantum discord remains non zero, so quantum discord is considered as indicator of disentanglement.
文摘Werner Herzog is a rebellious artist and lonely dreamer.Throughout his whole career, Herzog enthusiastically and persistently pursues cinematic dream, courting disasters and overcoming the seemingly insurmountable. This paper argues that Stroszek reflects Herzog's rebellious spirit and dream passion in its combination of the documentary with fiction, ecstatic truth and heroic characters.
基金supported by the Prospective Future Network Project of Jiangsu Province,China(Grant No.BY2013095-1-18)the Independent Project of State Key Laboratory of Millimeter Waves(Grant No.Z201504)
文摘Many previous studies about teleportation are based on pure state. Study of quantum channel as mixed state is more realistic but complicated as pure states degenerate into mixed states by interaction with environment, and the Werner state plays an important role in the study of the mixed state. In this paper, the quantum wireless multihop network is proposed and the information is transmitted hop by hop through teleportation. We deduce a specific expression of the recovered state not only after one-hop teleportation but also across multiple intermediate nodes based on Werner state in a quantum wireless multihop network. We also obtain the fidelity of multihop teleportation.
基金Supported by National Natural Science Foundation of under Grant Nos. 11001159,11171197supported by the Fundamental Research Funds for the Central Universities GK200902049,GK201002012,and GK201001002
文摘In this note,we give a new lower bound for the concurrence,which is related to D-concurrence.For the Werner states,we compare that this D-concurrence bound with the other known bound.In addition,some of new upper and lower bounds of D-concurrence are given.
基金the Foundation for Polish Science(FNP)(project First Team cofinanced by the European Union under the European Regional Development Fund)。
文摘In this article,we introduce a framework for entanglement quantification of photon pairs represented by two-qubit Werner states.The measurement scheme is based on the symmetric informationally complete POVM.To make the framework realistic,we impose the Poisson noise on the measured two-photon coincidences.For various settings,numerical simulations were performed to evaluate the efficiency of the framework.
文摘The grisly 1937 murder of 19-year-old Pamela Werner was first "solved" by Paul French's award-winning Midnight in Peking. Published in 2011, French's book was a minor sensation, a lurid rickshaw ride through the fetid nether regions of Beijing society. Now a rival publication by fellow Brit and former policeman Graeme Sheppard claims to overturn that rickshaw and set the record straight.
基金This work was partly supported by the Lo Kwee-Seong Biomedical Research Fund and the Chinese University of Hong Kong(CUHK)Vice Chancellor(VC)Discretionary Fund.
文摘Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatricdiseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development ofcardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become thefocus in aging research. Natural aging is not regarded as a programmed process. However, accelerated agingdue to inherited genetic defects in patients of progeria is programmed and resembles many aspects ofnatural aging. Among several premature aging syndromes, Werner syndrome (WS) and Hutchinson–Gilfordprogeria syndrome (HGPS) are two broadly investigated diseases. In this review, we discuss how stem cellaging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigeneticlandscape in aged cells can be reversed to a “juvenile” state. Lastly, we explore the potential application ofthe latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.
