目的:总结膝关节疼痛患者敏化穴、激痛点、筋结点、软外压痛点的分布特征,探讨敏化穴与激痛点、筋结点、软外压痛点的相关性。方法:检索The Cochrane Library、PubMed、Web of Science、中国期刊全文数据库(CNKI)、万方数据库(WanFang)...目的:总结膝关节疼痛患者敏化穴、激痛点、筋结点、软外压痛点的分布特征,探讨敏化穴与激痛点、筋结点、软外压痛点的相关性。方法:检索The Cochrane Library、PubMed、Web of Science、中国期刊全文数据库(CNKI)、万方数据库(WanFang)、维普数据库(VIP)、中国生物医学文献数据库(CBM),收集有关通过敏化穴和体表压痛点治疗膝关节疼痛的临床研究,提取敏化穴位与体表压痛点位置、频数、频率等,绘制敏化穴与体表压痛点分布图,计算敏化穴与体表压痛点重合率,分析敏化穴与体表压痛点相关性。结果:12篇文献3585例膝关节敏化穴与激痛点的重合率为6.21%;敏化穴与筋结点的重合率为68.35%;敏化穴与软外压痛点的重合率为21.87%;与3类体表压痛点总重合率为96.40%。结论:穴位敏化与激痛点、筋结点、软外压痛点有一定的相关性,穴位敏化的产生机制可能不止一种,依据其解剖位置、病理改变、敏化形式等因素,其敏化发生机制各不相同。展开更多
BACKGROUND Current clinical treatment options for symptomatic,partial-thickness rotator cuff tear(sPTRCT)offer only limited potential for true tissue healing and improvement of clinical results.In animal models,inject...BACKGROUND Current clinical treatment options for symptomatic,partial-thickness rotator cuff tear(sPTRCT)offer only limited potential for true tissue healing and improvement of clinical results.In animal models,injections of adult stem cells isolated from adipose tissue into tendon injuries evidenced histological regeneration of tendon tissue.However,it is unclear whether such beneficial effects could also be observed in a human tendon treated with fresh,uncultured,autologous,adipose derived regenerative cells(UA-ADRCs).A specific challenge in this regard is that UA-ADRCs cannot be labeled and,thus,not unequivocally identified in the host tissue.Therefore,histological regeneration of injured human tendons after injection of UA-ADRCs must be assessed using comprehensive,immunohistochemical and microscopic analysis of biopsies taken from the treated tendon a few weeks after injection of UA-ADRCs.CASE SUMMARY A 66-year-old patient suffered from sPTRCT affecting the right supraspinatus and infraspinatus tendon,caused by a bicycle accident.On day 18 post injury[day 16 post magnetic resonance imaging(MRI)examination]approximately 100 g of abdominal adipose tissue was harvested by liposuction,from which approximately 75×10^(6) UA-ADRCs were isolated within 2 h.Then,UA-ADRCs were injected(controlled by biplanar X-ray imaging)adjacent to the injured supraspinatus tendon immediately after isolation.Despite fast clinical recovery,a follow-up MRI examination 2.5 mo post treatment indicated the need for open revision of the injured infraspinatus tendon,which had not been treated with UAADRCs.During this operation,a biopsy was taken from the supraspinatus tendon at the position of the injury.A comprehensive,immunohistochemical and microscopic analysis of the biopsy(comprising 13 antibodies)was indicative of newly formed tendon tissue.CONCLUSION Injection of UA-ADRCs can result in regeneration of injured human tendons by formation of new tendon tissue.展开更多
文摘目的:总结膝关节疼痛患者敏化穴、激痛点、筋结点、软外压痛点的分布特征,探讨敏化穴与激痛点、筋结点、软外压痛点的相关性。方法:检索The Cochrane Library、PubMed、Web of Science、中国期刊全文数据库(CNKI)、万方数据库(WanFang)、维普数据库(VIP)、中国生物医学文献数据库(CBM),收集有关通过敏化穴和体表压痛点治疗膝关节疼痛的临床研究,提取敏化穴位与体表压痛点位置、频数、频率等,绘制敏化穴与体表压痛点分布图,计算敏化穴与体表压痛点重合率,分析敏化穴与体表压痛点相关性。结果:12篇文献3585例膝关节敏化穴与激痛点的重合率为6.21%;敏化穴与筋结点的重合率为68.35%;敏化穴与软外压痛点的重合率为21.87%;与3类体表压痛点总重合率为96.40%。结论:穴位敏化与激痛点、筋结点、软外压痛点有一定的相关性,穴位敏化的产生机制可能不止一种,依据其解剖位置、病理改变、敏化形式等因素,其敏化发生机制各不相同。
文摘BACKGROUND Current clinical treatment options for symptomatic,partial-thickness rotator cuff tear(sPTRCT)offer only limited potential for true tissue healing and improvement of clinical results.In animal models,injections of adult stem cells isolated from adipose tissue into tendon injuries evidenced histological regeneration of tendon tissue.However,it is unclear whether such beneficial effects could also be observed in a human tendon treated with fresh,uncultured,autologous,adipose derived regenerative cells(UA-ADRCs).A specific challenge in this regard is that UA-ADRCs cannot be labeled and,thus,not unequivocally identified in the host tissue.Therefore,histological regeneration of injured human tendons after injection of UA-ADRCs must be assessed using comprehensive,immunohistochemical and microscopic analysis of biopsies taken from the treated tendon a few weeks after injection of UA-ADRCs.CASE SUMMARY A 66-year-old patient suffered from sPTRCT affecting the right supraspinatus and infraspinatus tendon,caused by a bicycle accident.On day 18 post injury[day 16 post magnetic resonance imaging(MRI)examination]approximately 100 g of abdominal adipose tissue was harvested by liposuction,from which approximately 75×10^(6) UA-ADRCs were isolated within 2 h.Then,UA-ADRCs were injected(controlled by biplanar X-ray imaging)adjacent to the injured supraspinatus tendon immediately after isolation.Despite fast clinical recovery,a follow-up MRI examination 2.5 mo post treatment indicated the need for open revision of the injured infraspinatus tendon,which had not been treated with UAADRCs.During this operation,a biopsy was taken from the supraspinatus tendon at the position of the injury.A comprehensive,immunohistochemical and microscopic analysis of the biopsy(comprising 13 antibodies)was indicative of newly formed tendon tissue.CONCLUSION Injection of UA-ADRCs can result in regeneration of injured human tendons by formation of new tendon tissue.
