Objective: The objective of this study was to investigate the relationship between the triglyceride-glucose (TyG) index, triglyceride-glucose-BMI (TyG-BMI) index, laboratory indices, and disease severity in patients w...Objective: The objective of this study was to investigate the relationship between the triglyceride-glucose (TyG) index, triglyceride-glucose-BMI (TyG-BMI) index, laboratory indices, and disease severity in patients with COVID-19. Methods: A retrospective analysis of COVID-19 patients treated at a tertiary hospital in Mianyang City, Sichuan Province, China, from 1 May to 31 May 2023 was performed. The patients were divided into two groups: 66 cases in the moderate group and 61 cases in the severe group. Additionally, 69 uninfected individuals from the medical examination center during the same period were selected as the control group. Spearman rank correlation was used to determine the correlation between the indices and COVID-19 severity. Multiple logistic regression analysis was performed to identify the factors affecting COVID-19 severity. ROC curves were constructed to assess the predictive value of the TyG and TyG-BMI indices for severe COVID-19. Results: There were significant differences in smoking and diabetes between the three groups (P Conclusion: Smoking, AST, ALB, TyG index, and TyG-BMI index are valuable in assessing the severity of COVID-19, with the TyG-BMI index having a higher predictive value than the TyG index.展开更多
目的探讨冠心病(CHD)患者甘油三酯葡萄糖乘积指数(Ty G index)与肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的关系。方法选取2007年9月—2011年8月该院收治的171例行冠状动脉造影者,采集所有患者的血压、冠脉病变积分(CAS)、血糖血脂和...目的探讨冠心病(CHD)患者甘油三酯葡萄糖乘积指数(Ty G index)与肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的关系。方法选取2007年9月—2011年8月该院收治的171例行冠状动脉造影者,采集所有患者的血压、冠脉病变积分(CAS)、血糖血脂和炎症指标。采用ELASA法测定血清中TNF-α、IL-6水平。以标准Judkins法行冠状动脉造影术,计算机定量分析系统分析冠状动脉狭窄程度并计算CAS。结果 TNF-α、IL-6、WC、BMI、WHR、Whi R、TC、HDL-C、CAS与Ty G index呈明显相关,相关指数分别为0.543、0.385、0.167、0.178、0.157、0.184、0.201、-0.180、0.273。结论 TNF-α、IL-6、CAS与Ty G index密切相关,因此Ty G index作为CHD发生发展的良好预测指标,可用于临床指导CHD危险人群的早期干预。展开更多
Introduction: Hepatitis C virus (HCV) genotype 4 is the most prevalent in Egypt. Vis-ceral adiposity index (VAI) and (TyG) index are newly developed indices for assess-ment of metabolic syndrome (MS) and insulin resis...Introduction: Hepatitis C virus (HCV) genotype 4 is the most prevalent in Egypt. Vis-ceral adiposity index (VAI) and (TyG) index are newly developed indices for assess-ment of metabolic syndrome (MS) and insulin resistance (IR). We aimed at comparing their levels in HCV-patients with healthy controls and validate their use for prediction of hepatic histopathological changes. Patient and Methods: 78 chronic HCV-infected patients proven by PCR, viral genotyping and hepatic histopathology, and 67 healthy controls were enrolled. Presence of MS, Homeostasis Model Assessment for IR esti-mation (HOMA-IR), TyG index, and VAI were assessed. Results: HOMA-IR, TyG and frequency of MS were significantly higher in patients’ group (p p p = 0.002). Conclusion: HCV genotype 4 is significantly associated with MS and increased values of HOMA IR and TyG index. TyG index and VAI are valuable simple indices that could predict the histopathological changes in Egyptian CHC pa-tients.展开更多
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. There is no specific biomarker for the diagnosis of NAFLD. Trigly-ceride and glucose index (TyG) may predict the subsequent occurrence of ...Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. There is no specific biomarker for the diagnosis of NAFLD. Trigly-ceride and glucose index (TyG) may predict the subsequent occurrence of NAFLD in later life. This cross sectional study was aimed to evaluate the effectiveness of triglyceride and glucose index (TyG) as a possible biomarker of NAFLD. The study was conducted at the Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2019 to February 2020. A total of 124 subjects were taken as study population following selection criteria. Among them 62 were diagnosed patients of NAFLD and 62 were healthy subjects as control group. Fasting plasma glucose was measured by glucose oxidase method and serum triglyceride was measured by enzymatic-colorimetric method, while TyG index was calculated accordingly. The mean age was 39.5 ± 11.27 years in NAFLD patients and 37.10 ± 12.28 years in control subjects with male female ratio 1:1.7 and 1:1.8 respectively. Major portion of NAFLD patients (62.9%) were overweight (BMI ≥ 25). The mean fasting plasma glucose level was 5.73 ± 1.47 mmol/L in NAFLD patients and 5.27 ± 0.69 mmol/L in control group (p < 0.027). The mean serum triglyceride level was 237.19 ± 96.47 mg/dl in NAFLD patients and 117.32 ± 53.07 mg/dl in control group (p < 0.001). The triglyceride and glucose index (TyG) was 9.36 ± 0.47 in NAFLD group and 8.53 ± 0.42 in control group. TyG index was significantly higher in NAFLD patients in comparison to control group (p < 0.001). In ROC analysis, cut off value of TyG index was 8.85 with sensitivity 93.5% and specificity 79%. As a fast and effective method, TyG index can be used as a diagnostic tool to predict NAFLD.展开更多
文摘Objective: The objective of this study was to investigate the relationship between the triglyceride-glucose (TyG) index, triglyceride-glucose-BMI (TyG-BMI) index, laboratory indices, and disease severity in patients with COVID-19. Methods: A retrospective analysis of COVID-19 patients treated at a tertiary hospital in Mianyang City, Sichuan Province, China, from 1 May to 31 May 2023 was performed. The patients were divided into two groups: 66 cases in the moderate group and 61 cases in the severe group. Additionally, 69 uninfected individuals from the medical examination center during the same period were selected as the control group. Spearman rank correlation was used to determine the correlation between the indices and COVID-19 severity. Multiple logistic regression analysis was performed to identify the factors affecting COVID-19 severity. ROC curves were constructed to assess the predictive value of the TyG and TyG-BMI indices for severe COVID-19. Results: There were significant differences in smoking and diabetes between the three groups (P Conclusion: Smoking, AST, ALB, TyG index, and TyG-BMI index are valuable in assessing the severity of COVID-19, with the TyG-BMI index having a higher predictive value than the TyG index.
文摘目的探讨冠心病(CHD)患者甘油三酯葡萄糖乘积指数(Ty G index)与肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的关系。方法选取2007年9月—2011年8月该院收治的171例行冠状动脉造影者,采集所有患者的血压、冠脉病变积分(CAS)、血糖血脂和炎症指标。采用ELASA法测定血清中TNF-α、IL-6水平。以标准Judkins法行冠状动脉造影术,计算机定量分析系统分析冠状动脉狭窄程度并计算CAS。结果 TNF-α、IL-6、WC、BMI、WHR、Whi R、TC、HDL-C、CAS与Ty G index呈明显相关,相关指数分别为0.543、0.385、0.167、0.178、0.157、0.184、0.201、-0.180、0.273。结论 TNF-α、IL-6、CAS与Ty G index密切相关,因此Ty G index作为CHD发生发展的良好预测指标,可用于临床指导CHD危险人群的早期干预。
文摘Introduction: Hepatitis C virus (HCV) genotype 4 is the most prevalent in Egypt. Vis-ceral adiposity index (VAI) and (TyG) index are newly developed indices for assess-ment of metabolic syndrome (MS) and insulin resistance (IR). We aimed at comparing their levels in HCV-patients with healthy controls and validate their use for prediction of hepatic histopathological changes. Patient and Methods: 78 chronic HCV-infected patients proven by PCR, viral genotyping and hepatic histopathology, and 67 healthy controls were enrolled. Presence of MS, Homeostasis Model Assessment for IR esti-mation (HOMA-IR), TyG index, and VAI were assessed. Results: HOMA-IR, TyG and frequency of MS were significantly higher in patients’ group (p p p = 0.002). Conclusion: HCV genotype 4 is significantly associated with MS and increased values of HOMA IR and TyG index. TyG index and VAI are valuable simple indices that could predict the histopathological changes in Egyptian CHC pa-tients.
文摘Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. There is no specific biomarker for the diagnosis of NAFLD. Trigly-ceride and glucose index (TyG) may predict the subsequent occurrence of NAFLD in later life. This cross sectional study was aimed to evaluate the effectiveness of triglyceride and glucose index (TyG) as a possible biomarker of NAFLD. The study was conducted at the Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2019 to February 2020. A total of 124 subjects were taken as study population following selection criteria. Among them 62 were diagnosed patients of NAFLD and 62 were healthy subjects as control group. Fasting plasma glucose was measured by glucose oxidase method and serum triglyceride was measured by enzymatic-colorimetric method, while TyG index was calculated accordingly. The mean age was 39.5 ± 11.27 years in NAFLD patients and 37.10 ± 12.28 years in control subjects with male female ratio 1:1.7 and 1:1.8 respectively. Major portion of NAFLD patients (62.9%) were overweight (BMI ≥ 25). The mean fasting plasma glucose level was 5.73 ± 1.47 mmol/L in NAFLD patients and 5.27 ± 0.69 mmol/L in control group (p < 0.027). The mean serum triglyceride level was 237.19 ± 96.47 mg/dl in NAFLD patients and 117.32 ± 53.07 mg/dl in control group (p < 0.001). The triglyceride and glucose index (TyG) was 9.36 ± 0.47 in NAFLD group and 8.53 ± 0.42 in control group. TyG index was significantly higher in NAFLD patients in comparison to control group (p < 0.001). In ROC analysis, cut off value of TyG index was 8.85 with sensitivity 93.5% and specificity 79%. As a fast and effective method, TyG index can be used as a diagnostic tool to predict NAFLD.
