Laparoscopic wedge resection is a useful procedure fortreating patients with submucosal tumor(SMT) including gastrointestinal stromal tumor(GIST) of the stomach. However, resection of intragastric-type SMTs can be pro...Laparoscopic wedge resection is a useful procedure fortreating patients with submucosal tumor(SMT) including gastrointestinal stromal tumor(GIST) of the stomach. However, resection of intragastric-type SMTs can be problematic due to the difficulty in accurately judging the location of endoluminal tumor growth, and often excessive amounts of healthy mucosa are removed; thus, full-thickness local excision using laparoscopic and endoscopic cooperative surgery(LECS) is a promising procedure for these cases. Our experience with LECS has confirmed this procedure to be a safe, feasible, and minimally invasive treatment method for gastric GISTs less than 5 cm in diameter, with outcomes similar to conventional laparoscopic wedge resection. The important advantage of LECS is the reduction in the resected area of the gastric wall compared to that in conventional laparoscopic wedge resection using a linear stapler. Early gastric cancer fits the criteria for endoscopic resection; however, if performing endoscopic submucosal dissection is difficult, the LECS procedure might be a good alternative. In the future, LECS is also likely to be indicated for duodenal tumors, as well as gastric tumors. Furthermore, developments in endoscopic and laparoscopic technology have generated various modified LECS techniques, leading to even less invasive surgery.展开更多
Nb-doped TiC ceramic,or (NbyTi1-y) Cx,in which amount of Nb element added is increased from zero to 40Wt. %, synthisized -with self-propagating high temperature synthesis,is studied with SCF-Xa-DV,a quantum chemistry ...Nb-doped TiC ceramic,or (NbyTi1-y) Cx,in which amount of Nb element added is increased from zero to 40Wt. %, synthisized -with self-propagating high temperature synthesis,is studied with SCF-Xa-DV,a quantum chemistry cal-culating method. The chemical bonding is studied to discuss the relation between structrues and properties. Several classes of models in which there is no vacancy,one vacancy or two vacan-cies have been calculated. From the calculated results of bond or-der, a measure of covalent bond strength,and molecule orbital contour map, it is concluded that when Nb element added in-creases, the vacancies increase correspondingly,the covalent com-ponent of chemical bonds of the samples decreases -while the met-al-bonding component increases, so the hardness and resistance of the samples decrease.展开更多
A new species of small tree frog from a primary montane tropical forest of central Vietnam, Tay Nguyen Plateau, is described based on morphological, molecular, and acoustic evidence. The Golden Bug-Eyed Frog, Theloder...A new species of small tree frog from a primary montane tropical forest of central Vietnam, Tay Nguyen Plateau, is described based on morphological, molecular, and acoustic evidence. The Golden Bug-Eyed Frog, Theloderma auratum sp. nov., is distinguishable from its congeners and other small rhacophorid species based on a combination of the following morphological attributes： （1） bony ridges on head absent; （2） smooth skin completely lacking calcified warts or asperities; （3） pointed elongated tapering snout; （4） vocal opening in males absent; （5） vomerine teeth absent; （6） males of small body size （SVL 21.8-26.4 mm）; （7） head longer than wide; ED/SVL ratio 13%-15%; ESL/SVL ratio 16%-20%; （8） small tympanum （TD/EL ratio 50%-60%） with few tiny tubercles; （9） supratympanic fold absent; （10） ventral surfaces completely smooth; （11 ） webbing between fingers absent; （12） outer and inner metacarpal tubercles present, supernumerary metacarpal tubercle single, medial, oval in shape; （13） toes half-webbed： I 2-21/4 II 11/^-23/~ III 2-31/4 IV 3-11/2 V; （14） inner metatarsal tubercle present, oval; outer metatarsal tubercle absent; （15） iris bicolored; （16） dorsal surfaces golden-yellow with sparse golden-orange speckling or reticulations and few small dark-brown spots; （17） lateral sides of head and body with wide dark reddish-brown to black lateral stripes, clearlyseparated from lighter dorsal coloration by straight contrasting edge; （18） ventral surfaces of body, throat, and chest greyish-blue with indistinct brown confluent blotches; （19） upper eyelids with few （3-5） very small flat reddish superciliary tubercles; （20） limbs dorsally reddish-brown, ventrally brown with small bluish-white speckles. The new species is also distinct from all congeners in 12S rRNA to 16S rRNA mitochondrial DNA fragment sequences （uncorrected genetic distance P〉8.9%）. Advertisement call and tadpole morphology of the new species are described.展开更多
Nanoparticles(NPs)which are innovation and research focus in drug delivery systems,still have some disadvantages limiting its application in clinical use,such as short circulation time,recognition and clearance by ret...Nanoparticles(NPs)which are innovation and research focus in drug delivery systems,still have some disadvantages limiting its application in clinical use,such as short circulation time,recognition and clearance by reticuloendothelial system(RES)and passive targeting in certain organs.However,the recent combination of natural components and nanotechnology has offered new solutions to address these problems.A novel biomimetic platform consisting of nanoparticle core and membrane shell,such as cell membrane,exosome or vesicle vastly improves properties of nanoparticles.These coated nanoparticles can replicate the unique functions of the membrane,such as prolonged blood circulation,active targeting capability and enhanced internalization.In this review,we focus on the newest development of biological-camouflaged nanoparticles and mainly introduce its application related to cancer therapy and toll-like receptor.展开更多
This paper describes the required testing and approval procedures of new track systems operated in Europe. To begin with, test methods and performance specifications according to European Standard （EN） are outlined....This paper describes the required testing and approval procedures of new track systems operated in Europe. To begin with, test methods and performance specifications according to European Standard （EN） are outlined. These include the repeated loading test, the determination of the static and dynamic stiffness of rail pads, clamping force and longitudinal rail resistance. The fact that labor tests are unable to simulate all the conditions in situ shows that these labor tests are not sufficient for the evaluation of the long term behaviour of a new track system： a test track of sufficient length must be constructed and exposed to traffic loads. In Europe to be accredited as a new system, a new slab track system must have a trial time of more than two years, during which the features of the whole system can be recognized. In the second part of this paper, the experience of the Institute of Road, Railway and Airfield Construction of TUM concerning the measuring methods of slab track systems carrying traffic are outlined. Also the approval procedure of the new slab tracks in Germany is discussed.展开更多
We apply the energy momentum and angular momentum tensor to a tetrad field, with two unknown functions of radial coordinate, in the framework of a teleparallel equivalent of general relativity （TEGR）. The definition...We apply the energy momentum and angular momentum tensor to a tetrad field, with two unknown functions of radial coordinate, in the framework of a teleparallel equivalent of general relativity （TEGR）. The definition of the gravitational energy is used to investigate the energy within the external event horizon of the dyadosphere region for the Reissner-NordstrSm black hole. We also calculate the spatial momentum and angular momentum.展开更多
Polaronic effect is important in the current researches on quantum dots (QD). This paper reported a new concept of the 'confined polaron', their size dependent formation possibilities and energy variation in d...Polaronic effect is important in the current researches on quantum dots (QD). This paper reported a new concept of the 'confined polaron', their size dependent formation possibilities and energy variation in different QD systems, with an indication of contribution from both intrinsic and/or extrinsic phonons. To understand the spectro-scopic characteristics of porous silicon (PS), we find that luminescence behavior of oxidized porous silicon is in good agreement with the model of interfacial confined polaron in QDs. This conclusion is useful to unveiling the mechanmism of PS luminescence.展开更多
Currently there is an increase in the emergence and re-emergence of bacterial infections,and lichens are potential sources of pharmaceutically important secondary metabolites to halt this problem.Lichens are unique pl...Currently there is an increase in the emergence and re-emergence of bacterial infections,and lichens are potential sources of pharmaceutically important secondary metabolites to halt this problem.Lichens are unique plant-like organisms which are relatively less explored in the Philippines.Here,lichen extracts of Leptogium cochleatum and Leptogium moluccanum were tested against Escherichia coli,Enterobacter agglomerans,Klebsiella pneumoniae,Pseudomonas aeruginosa,and Staphylococcus aureus using paper disk diffusion assay.Hexane extract of L.moluccanum led to a 17.14 mm zone of inhibition(ZOI)against K.pneumoniae,while hexane extract of L.cochleatum led to a 15.28 mm ZOI against E.agglomerans.Dichloromethane extracts of L.cochleatum exhibited a ZOI of 15.86 mm against E.agglomerans and 14.84 mm ZOI against E.coli.The bioactivities exhibited by the lichen extracts may be due to the secondary metabolites detected using thin layer chromatography.Indeed,lichen-derived bioactive compounds hold great promise for pharmaceutical applications for the benefit of human life.展开更多
A novel molecular probe system(NapTpa-dnbs)was prepared based on the chromophore napthalimide fused triphenylamine unit.NapTpa-dnbs was tuned to absorb a large fraction of UV and near-infrared radiation.The turn-on fl...A novel molecular probe system(NapTpa-dnbs)was prepared based on the chromophore napthalimide fused triphenylamine unit.NapTpa-dnbs was tuned to absorb a large fraction of UV and near-infrared radiation.The turn-on fluorescent response of NapTpa-dnbs to thiophenol caused an increased fluorescent emission by a factor of 11.5 at 597 nm in a PBS buffer solution.The photoinduced electron transform(PET)process of the probe became less feasible with the addition of thiophenol than that of the free probe.NapTpa-dnbs demonstrated high selective and sensitive detection toward thiophenol with respect to other competitive amine acids.The detection limit was determined to be 2.03×10^?7 mol/L thiophenol.The sensing process is rapid(3 min).NapTpa-dnbs can accurately detect the thiophenol with a qualified recovery in real water samples.NapTpa-dnbs on test strips can detect the thiophenol vapour in the atmosphere.展开更多
文摘Laparoscopic wedge resection is a useful procedure fortreating patients with submucosal tumor(SMT) including gastrointestinal stromal tumor(GIST) of the stomach. However, resection of intragastric-type SMTs can be problematic due to the difficulty in accurately judging the location of endoluminal tumor growth, and often excessive amounts of healthy mucosa are removed; thus, full-thickness local excision using laparoscopic and endoscopic cooperative surgery(LECS) is a promising procedure for these cases. Our experience with LECS has confirmed this procedure to be a safe, feasible, and minimally invasive treatment method for gastric GISTs less than 5 cm in diameter, with outcomes similar to conventional laparoscopic wedge resection. The important advantage of LECS is the reduction in the resected area of the gastric wall compared to that in conventional laparoscopic wedge resection using a linear stapler. Early gastric cancer fits the criteria for endoscopic resection; however, if performing endoscopic submucosal dissection is difficult, the LECS procedure might be a good alternative. In the future, LECS is also likely to be indicated for duodenal tumors, as well as gastric tumors. Furthermore, developments in endoscopic and laparoscopic technology have generated various modified LECS techniques, leading to even less invasive surgery.
文摘Nb-doped TiC ceramic,or (NbyTi1-y) Cx,in which amount of Nb element added is increased from zero to 40Wt. %, synthisized -with self-propagating high temperature synthesis,is studied with SCF-Xa-DV,a quantum chemistry cal-culating method. The chemical bonding is studied to discuss the relation between structrues and properties. Several classes of models in which there is no vacancy,one vacancy or two vacan-cies have been calculated. From the calculated results of bond or-der, a measure of covalent bond strength,and molecule orbital contour map, it is concluded that when Nb element added in-creases, the vacancies increase correspondingly,the covalent com-ponent of chemical bonds of the samples decreases -while the met-al-bonding component increases, so the hardness and resistance of the samples decrease.
基金partially supported by the Russian Foundation of Basic Research(RFBR 15-29-02771RFBR17-54-54002_viet_a)molecular analyses,preservation,and storage of specimens were carried out with financial support from the Russian Science Foundation(RSF 14-50-00029)
文摘A new species of small tree frog from a primary montane tropical forest of central Vietnam, Tay Nguyen Plateau, is described based on morphological, molecular, and acoustic evidence. The Golden Bug-Eyed Frog, Theloderma auratum sp. nov., is distinguishable from its congeners and other small rhacophorid species based on a combination of the following morphological attributes： （1） bony ridges on head absent; （2） smooth skin completely lacking calcified warts or asperities; （3） pointed elongated tapering snout; （4） vocal opening in males absent; （5） vomerine teeth absent; （6） males of small body size （SVL 21.8-26.4 mm）; （7） head longer than wide; ED/SVL ratio 13%-15%; ESL/SVL ratio 16%-20%; （8） small tympanum （TD/EL ratio 50%-60%） with few tiny tubercles; （9） supratympanic fold absent; （10） ventral surfaces completely smooth; （11 ） webbing between fingers absent; （12） outer and inner metacarpal tubercles present, supernumerary metacarpal tubercle single, medial, oval in shape; （13） toes half-webbed： I 2-21/4 II 11/^-23/~ III 2-31/4 IV 3-11/2 V; （14） inner metatarsal tubercle present, oval; outer metatarsal tubercle absent; （15） iris bicolored; （16） dorsal surfaces golden-yellow with sparse golden-orange speckling or reticulations and few small dark-brown spots; （17） lateral sides of head and body with wide dark reddish-brown to black lateral stripes, clearlyseparated from lighter dorsal coloration by straight contrasting edge; （18） ventral surfaces of body, throat, and chest greyish-blue with indistinct brown confluent blotches; （19） upper eyelids with few （3-5） very small flat reddish superciliary tubercles; （20） limbs dorsally reddish-brown, ventrally brown with small bluish-white speckles. The new species is also distinct from all congeners in 12S rRNA to 16S rRNA mitochondrial DNA fragment sequences （uncorrected genetic distance P〉8.9%）. Advertisement call and tadpole morphology of the new species are described.
基金We thank the financial support from the National Natural Science Foundation of China(No.81773558)the Natural Science Foundation of Guangdong Province(Nos.2020A 151501518 and 2018B 030312010)the Science and Technology Program of Guangzhou(No.201904010380)for this work.
文摘Nanoparticles(NPs)which are innovation and research focus in drug delivery systems,still have some disadvantages limiting its application in clinical use,such as short circulation time,recognition and clearance by reticuloendothelial system(RES)and passive targeting in certain organs.However,the recent combination of natural components and nanotechnology has offered new solutions to address these problems.A novel biomimetic platform consisting of nanoparticle core and membrane shell,such as cell membrane,exosome or vesicle vastly improves properties of nanoparticles.These coated nanoparticles can replicate the unique functions of the membrane,such as prolonged blood circulation,active targeting capability and enhanced internalization.In this review,we focus on the newest development of biological-camouflaged nanoparticles and mainly introduce its application related to cancer therapy and toll-like receptor.
文摘This paper describes the required testing and approval procedures of new track systems operated in Europe. To begin with, test methods and performance specifications according to European Standard （EN） are outlined. These include the repeated loading test, the determination of the static and dynamic stiffness of rail pads, clamping force and longitudinal rail resistance. The fact that labor tests are unable to simulate all the conditions in situ shows that these labor tests are not sufficient for the evaluation of the long term behaviour of a new track system： a test track of sufficient length must be constructed and exposed to traffic loads. In Europe to be accredited as a new system, a new slab track system must have a trial time of more than two years, during which the features of the whole system can be recognized. In the second part of this paper, the experience of the Institute of Road, Railway and Airfield Construction of TUM concerning the measuring methods of slab track systems carrying traffic are outlined. Also the approval procedure of the new slab tracks in Germany is discussed.
文摘We apply the energy momentum and angular momentum tensor to a tetrad field, with two unknown functions of radial coordinate, in the framework of a teleparallel equivalent of general relativity （TEGR）. The definition of the gravitational energy is used to investigate the energy within the external event horizon of the dyadosphere region for the Reissner-NordstrSm black hole. We also calculate the spatial momentum and angular momentum.
文摘Polaronic effect is important in the current researches on quantum dots (QD). This paper reported a new concept of the 'confined polaron', their size dependent formation possibilities and energy variation in different QD systems, with an indication of contribution from both intrinsic and/or extrinsic phonons. To understand the spectro-scopic characteristics of porous silicon (PS), we find that luminescence behavior of oxidized porous silicon is in good agreement with the model of interfacial confined polaron in QDs. This conclusion is useful to unveiling the mechanmism of PS luminescence.
文摘Currently there is an increase in the emergence and re-emergence of bacterial infections,and lichens are potential sources of pharmaceutically important secondary metabolites to halt this problem.Lichens are unique plant-like organisms which are relatively less explored in the Philippines.Here,lichen extracts of Leptogium cochleatum and Leptogium moluccanum were tested against Escherichia coli,Enterobacter agglomerans,Klebsiella pneumoniae,Pseudomonas aeruginosa,and Staphylococcus aureus using paper disk diffusion assay.Hexane extract of L.moluccanum led to a 17.14 mm zone of inhibition(ZOI)against K.pneumoniae,while hexane extract of L.cochleatum led to a 15.28 mm ZOI against E.agglomerans.Dichloromethane extracts of L.cochleatum exhibited a ZOI of 15.86 mm against E.agglomerans and 14.84 mm ZOI against E.coli.The bioactivities exhibited by the lichen extracts may be due to the secondary metabolites detected using thin layer chromatography.Indeed,lichen-derived bioactive compounds hold great promise for pharmaceutical applications for the benefit of human life.
文摘A novel molecular probe system(NapTpa-dnbs)was prepared based on the chromophore napthalimide fused triphenylamine unit.NapTpa-dnbs was tuned to absorb a large fraction of UV and near-infrared radiation.The turn-on fluorescent response of NapTpa-dnbs to thiophenol caused an increased fluorescent emission by a factor of 11.5 at 597 nm in a PBS buffer solution.The photoinduced electron transform(PET)process of the probe became less feasible with the addition of thiophenol than that of the free probe.NapTpa-dnbs demonstrated high selective and sensitive detection toward thiophenol with respect to other competitive amine acids.The detection limit was determined to be 2.03×10^?7 mol/L thiophenol.The sensing process is rapid(3 min).NapTpa-dnbs can accurately detect the thiophenol with a qualified recovery in real water samples.NapTpa-dnbs on test strips can detect the thiophenol vapour in the atmosphere.
