The contribution of angiogenesis inhibitor TNP- 4 70 to the growth and m etastasis of ACHN renal cell carcinom a (RCC) was studied. TNP- 4 70 (40 m g/ kg,every two days) was ad- ministrated to BABL / c nude m ice be...The contribution of angiogenesis inhibitor TNP- 4 70 to the growth and m etastasis of ACHN renal cell carcinom a (RCC) was studied. TNP- 4 70 (40 m g/ kg,every two days) was ad- ministrated to BABL / c nude m ice bearing ACHN RCC. The mice were sacrificed after a treatment duration of 31days and the weight and volum e of subcutaneous tum ors as well as foci of lung m etastasis were m easured.The microvascular density(MVD) of the tumor as well as the PCNA index and apoptotic index of the tum or cells were evaluated imm unohistochem ically. Result showed that the growth of ACHN RCC was suppressed significantly and none metastasis was ob- served in TNP- 4 70 - treated m ice. Compared with the control group,the MVD was decreased m arkedly (P<0 .0 1) and the apoptotic index was increased significantly (P<0 .0 1) in the treated group. The tumor volume was positively correlated to the MVD (r=0 .714 4 ,P<0 .0 1) and in- versely correlated to the apoptotic index(r=- 0 .86 0 7,P<0 .0 1) ,and MVD was conversely cor- related to the apoptotic index.It was determ ined that TNP- 4 70 could effectively inhibit angiogene- sis of ACHN RCC,which resulting in ischemia and hypoxia,leading to increased apoptosis,thus obviously suppressing the growth and metastasis of ACHN RCC in nude m ice.展开更多
The investigation aims at the expansion of the basis of formulations of solid composite propellants by introducing new compositions with lower sensitivity to mechanic impact and improved thermal stability.The formulat...The investigation aims at the expansion of the basis of formulations of solid composite propellants by introducing new compositions with lower sensitivity to mechanic impact and improved thermal stability.The formulations based on trinitropyrazole(TNP)contains a binder(a hydrocarbon or active one),aluminum and inorganic oxidizer ADN.The results show that a binary formulation TNP+active binder(18%-19%)(volume fraction)with no metal is well designed which would achieve high specific impulse(at Pc∶Pa=40∶1)of 248s,high density of 1.80g/cm3 and combustion temperature Tcabout 3 450K.In terms of energy,metal-free compositions with TNP lose a bit to those with HMX,only if HMX fraction in formulation is higher than 45%-50%.展开更多
In this contribution, we reported a very simple and small molecule material, 2,5-dimethoxyterephthalaldehyde(DMA). It exhibited a relatively weak fluorescence in solution, while showed a steadily increased green fluor...In this contribution, we reported a very simple and small molecule material, 2,5-dimethoxyterephthalaldehyde(DMA). It exhibited a relatively weak fluorescence in solution, while showed a steadily increased green fluorescence with typical aggregation-induced enhanced emission(AIE) effect for forming a cubic-like microcrystal structure in THF-H2 O mixed solvent.The microcrystals presented significantly higher fluorescence than that of amorphous aggregates. The DMA microcrystals suspension showed a good response to 2,4,6-trinitrophenol(TNP) with a LOD of 1.2×10^(-7) M, which is the best result of TNP detection in aqueous solution. Quantum chemical calculation revealed that DMA is a donor(D)-receptor(A) type molecule with methoxy unit as donor and carbonyl moiety as receptor. Its emission arises from an intramolecular charge transfer(ICT) from methoxy units to carbonyl units. NMR indicated that there is a strong hydrogen bond interaction between DMA and TNP.Hydrogen bond interaction can effectively decrease the intermolecular distance of DMA and TNP, which will increase the efficiency of photoinduced electron transfer(PET) and fluorescence resonance energy transfer(FRET), and hence will be advantageous for its selectivity. The microcrystal induced enhanced emission could be generally used for kinds of target molecules analysis.展开更多
In this paper,we designed Eu^(2+)-doped BaAlF_(5) and BaSiF_(6) downconversion nanophosphors with strong f-f transition emission to realize the quantitative detection of TNP.The surface of the as-prepared nanophosphor...In this paper,we designed Eu^(2+)-doped BaAlF_(5) and BaSiF_(6) downconversion nanophosphors with strong f-f transition emission to realize the quantitative detection of TNP.The surface of the as-prepared nanophosphors was modified by polyethylenimine(PEI) to increase the water solubility and to provide a pair of electrons to bind to the benzene ring in TNP,forming a Meisenheimer complex.The detection principle of TNP is based on luminescence resonance energy transfer(LRET) technology,where the PEI-functionalized BaAlF_(5):Eu^(2+) and BaSiF_(6):Eu^(2+) nanophosphors are used as energy donors and TNP is an energy acceptor.With increasing TNP concentrations,the luminescence intensity of the BaAlF5:Eu^(2+) and BaSiF6:Eu^(2+) nanophosphors at 359 nm [^(4)f_(7)(^(6)P_(7/2))→^(4)f_(7)(^(8)S_(7/2)) transition of Eu^(2+)] displays dramatic luminescent quenching.The BaAlF_(5):Eu^(2+)@PEI or BaSiF_(6):Eu^(2+)@PEI nanophosphor downconversion luminescent sensors show great sensitivity and selectivity and good linearity,and the detection limits of TNP are 0.57 and 2.82 ng/mL,respectively.展开更多
文摘The contribution of angiogenesis inhibitor TNP- 4 70 to the growth and m etastasis of ACHN renal cell carcinom a (RCC) was studied. TNP- 4 70 (40 m g/ kg,every two days) was ad- ministrated to BABL / c nude m ice bearing ACHN RCC. The mice were sacrificed after a treatment duration of 31days and the weight and volum e of subcutaneous tum ors as well as foci of lung m etastasis were m easured.The microvascular density(MVD) of the tumor as well as the PCNA index and apoptotic index of the tum or cells were evaluated imm unohistochem ically. Result showed that the growth of ACHN RCC was suppressed significantly and none metastasis was ob- served in TNP- 4 70 - treated m ice. Compared with the control group,the MVD was decreased m arkedly (P<0 .0 1) and the apoptotic index was increased significantly (P<0 .0 1) in the treated group. The tumor volume was positively correlated to the MVD (r=0 .714 4 ,P<0 .0 1) and in- versely correlated to the apoptotic index(r=- 0 .86 0 7,P<0 .0 1) ,and MVD was conversely cor- related to the apoptotic index.It was determ ined that TNP- 4 70 could effectively inhibit angiogene- sis of ACHN RCC,which resulting in ischemia and hypoxia,leading to increased apoptosis,thus obviously suppressing the growth and metastasis of ACHN RCC in nude m ice.
基金Ministry of Education and Science of the Russian Federation(14.613.21.0043)
文摘The investigation aims at the expansion of the basis of formulations of solid composite propellants by introducing new compositions with lower sensitivity to mechanic impact and improved thermal stability.The formulations based on trinitropyrazole(TNP)contains a binder(a hydrocarbon or active one),aluminum and inorganic oxidizer ADN.The results show that a binary formulation TNP+active binder(18%-19%)(volume fraction)with no metal is well designed which would achieve high specific impulse(at Pc∶Pa=40∶1)of 248s,high density of 1.80g/cm3 and combustion temperature Tcabout 3 450K.In terms of energy,metal-free compositions with TNP lose a bit to those with HMX,only if HMX fraction in formulation is higher than 45%-50%.
基金supported by the Ministry of Science and Technology (2016YFA0200800)the National Natural Science Foundation of China (51473182, 61731016, 61771460)the Youth Innovation Promotion Association of Chinese Academy of Sciences (2015190)
文摘In this contribution, we reported a very simple and small molecule material, 2,5-dimethoxyterephthalaldehyde(DMA). It exhibited a relatively weak fluorescence in solution, while showed a steadily increased green fluorescence with typical aggregation-induced enhanced emission(AIE) effect for forming a cubic-like microcrystal structure in THF-H2 O mixed solvent.The microcrystals presented significantly higher fluorescence than that of amorphous aggregates. The DMA microcrystals suspension showed a good response to 2,4,6-trinitrophenol(TNP) with a LOD of 1.2×10^(-7) M, which is the best result of TNP detection in aqueous solution. Quantum chemical calculation revealed that DMA is a donor(D)-receptor(A) type molecule with methoxy unit as donor and carbonyl moiety as receptor. Its emission arises from an intramolecular charge transfer(ICT) from methoxy units to carbonyl units. NMR indicated that there is a strong hydrogen bond interaction between DMA and TNP.Hydrogen bond interaction can effectively decrease the intermolecular distance of DMA and TNP, which will increase the efficiency of photoinduced electron transfer(PET) and fluorescence resonance energy transfer(FRET), and hence will be advantageous for its selectivity. The microcrystal induced enhanced emission could be generally used for kinds of target molecules analysis.
基金the National Natural Science Foundation of China(21173034)the Fundamental Research Funds for the Central Universities of China(wd01206)。
文摘In this paper,we designed Eu^(2+)-doped BaAlF_(5) and BaSiF_(6) downconversion nanophosphors with strong f-f transition emission to realize the quantitative detection of TNP.The surface of the as-prepared nanophosphors was modified by polyethylenimine(PEI) to increase the water solubility and to provide a pair of electrons to bind to the benzene ring in TNP,forming a Meisenheimer complex.The detection principle of TNP is based on luminescence resonance energy transfer(LRET) technology,where the PEI-functionalized BaAlF_(5):Eu^(2+) and BaSiF_(6):Eu^(2+) nanophosphors are used as energy donors and TNP is an energy acceptor.With increasing TNP concentrations,the luminescence intensity of the BaAlF5:Eu^(2+) and BaSiF6:Eu^(2+) nanophosphors at 359 nm [^(4)f_(7)(^(6)P_(7/2))→^(4)f_(7)(^(8)S_(7/2)) transition of Eu^(2+)] displays dramatic luminescent quenching.The BaAlF_(5):Eu^(2+)@PEI or BaSiF_(6):Eu^(2+)@PEI nanophosphor downconversion luminescent sensors show great sensitivity and selectivity and good linearity,and the detection limits of TNP are 0.57 and 2.82 ng/mL,respectively.
