Objective: In order to study the role and significance of transforming growth factor beta-1 (TGF-β1 )mRNA in transplanted renal fibrosis(TRF). Methods: Renal pathologic changes and expression of TGF-β1 mRNA were obs...Objective: In order to study the role and significance of transforming growth factor beta-1 (TGF-β1 )mRNA in transplanted renal fibrosis(TRF). Methods: Renal pathologic changes and expression of TGF-β1 mRNA were observed using in situ hybridization technique. The normal renal tissue as a. control group. Results: Expression of TGF-β1, mRNA in the renal fibrosis increased, compared with that in the control group. The expression rate were co-related to the stage of TRF. Conclusion: TGF-β1 is related to the pathogenesis and development of TRF.展开更多
目的:探讨间充质干细胞对颞下关节炎患者血清PRG4及TGF-β1的软骨生成作用。方法:选取我院颞下颌关节炎患者72例,随机分为实验组和对照组。对照组予盐酸氨基葡萄糖片口服1个月,玻璃酸钠注射液颞下颌关节腔每周1次,注射4次治疗。实验组...目的:探讨间充质干细胞对颞下关节炎患者血清PRG4及TGF-β1的软骨生成作用。方法:选取我院颞下颌关节炎患者72例,随机分为实验组和对照组。对照组予盐酸氨基葡萄糖片口服1个月,玻璃酸钠注射液颞下颌关节腔每周1次,注射4次治疗。实验组予间充质干细胞培养、自体移植,生理盐水0.5 m L稀释细胞5×105个关节腔内注射,3天后再次相同剂量及方式注射。两组患者分别测定血清TGF-β1、IL-1α和PRG4蛋白表达,最大张口度测试及疼痛程度评分,并通过影像学检查,评估两组患者关节组织损伤修复时间。结果:1与对照组相比实验组TGF-β1和PRG4蛋白表达上升更迅速且维持在较高水平,IL-1α下降更显著,差异有统计学意义(P<0.05);2与对照组比较,实验组最大张口度增加、张口时疼痛评分下降,差异有统计学意义(P<0.05);3与对照组比较,实验组受损关节组织均修复时间更短,差异有统计学意义(P<0.05)。结论:间充质干细胞可通过调节血清TGF-β1、IL-1α水平和PRG4蛋白表达,促进软骨的生成,对改善预后,提高患者生活质量有重要意义。展开更多
文摘Objective: In order to study the role and significance of transforming growth factor beta-1 (TGF-β1 )mRNA in transplanted renal fibrosis(TRF). Methods: Renal pathologic changes and expression of TGF-β1 mRNA were observed using in situ hybridization technique. The normal renal tissue as a. control group. Results: Expression of TGF-β1, mRNA in the renal fibrosis increased, compared with that in the control group. The expression rate were co-related to the stage of TRF. Conclusion: TGF-β1 is related to the pathogenesis and development of TRF.
文摘目的:探讨间充质干细胞对颞下关节炎患者血清PRG4及TGF-β1的软骨生成作用。方法:选取我院颞下颌关节炎患者72例,随机分为实验组和对照组。对照组予盐酸氨基葡萄糖片口服1个月,玻璃酸钠注射液颞下颌关节腔每周1次,注射4次治疗。实验组予间充质干细胞培养、自体移植,生理盐水0.5 m L稀释细胞5×105个关节腔内注射,3天后再次相同剂量及方式注射。两组患者分别测定血清TGF-β1、IL-1α和PRG4蛋白表达,最大张口度测试及疼痛程度评分,并通过影像学检查,评估两组患者关节组织损伤修复时间。结果:1与对照组相比实验组TGF-β1和PRG4蛋白表达上升更迅速且维持在较高水平,IL-1α下降更显著,差异有统计学意义(P<0.05);2与对照组比较,实验组最大张口度增加、张口时疼痛评分下降,差异有统计学意义(P<0.05);3与对照组比较,实验组受损关节组织均修复时间更短,差异有统计学意义(P<0.05)。结论:间充质干细胞可通过调节血清TGF-β1、IL-1α水平和PRG4蛋白表达,促进软骨的生成,对改善预后,提高患者生活质量有重要意义。
