目的 探讨睡眠体位及相关因素对中重度阻塞性睡眠呼吸暂停(OSA)患者日间过度嗜睡(excessive daytime sleepiness,EDS)严重程度的影响。方法 选取2020年10月~2022年9月在临沂市人民医院睡眠中心收治的106例中重度OSA患者,其中男性91例,女...目的 探讨睡眠体位及相关因素对中重度阻塞性睡眠呼吸暂停(OSA)患者日间过度嗜睡(excessive daytime sleepiness,EDS)严重程度的影响。方法 选取2020年10月~2022年9月在临沂市人民医院睡眠中心收治的106例中重度OSA患者,其中男性91例,女性15例,所有患者均行多导睡眠监测(PSG)。根据Epworth嗜睡量表(ESS)评分将其分为三组,非EDS组48例(ESS≤10分),轻中度EDS组34例(10分<ESS<17分)和重度EDS组24例(ESS≥17分)。分别比较三组患者的一般资料、睡眠体位相关参数、PSG参数,并将组间比较差异有意义的指标与ESS评分行相关性分析,二元logistic回归分析影响中重度OSA患者EDS程度的危险因素。结果 一般资料组间比较,体质量指数(BMI)、颈围和高血压方面差异具有统计学意义(F=3.607、7.797、χ2=8.690,P均<0.05)。其中轻中度组的颈围大于非EDS组,重度组的颈围及BMI均大于非EDS组(P均<0.05)。睡眠体位及PSG参数组间比较,仰卧位AHI、非仰卧位AHI、体位依赖性指数、AHI、非快速动眼期呼吸暂停低通气指数(NREM-AHI)、氧饱和度低于90%的百分比(percentage of total sleep time with oxygen saturation below90%,CT90%)、氧减饱和度指数(ODI)和微觉醒指数(micro-arousal index,MAI)差异有统计学意义(F=3.623、7.892、4.699、5.045、4.779、9.746、5.628、4.913,P均<0.05)。其中轻中度组和重度组的仰卧位AHI、非仰卧位AHI、CT90%、ODI、MAI、NREM-AHI、AHI均高于非EDS组(P均<0.05);重度组的体位依赖性指数显著低于非EDS组,且CT90%高于轻中度组(P均<0.05)。三组患者的ESS评分与仰卧位AHI、非仰卧位AHI、CT90%、ODI、MAI、NREM-AHI、AHI、BMI、颈围、高血压等指标均呈正相关关系(r=0.201、0.332、0.421、0.301、0.273、0.292、0.305、0.211、0.389、0.294,P均<0.05),与体位依赖性指数呈负相关关系(r=-0.282,P<0.05)。多因素分析显示:MAI是轻中度EDS组发病的独立危险因素(OR=1.036,P<0.05),颈围是重度E展开更多
BACKGROUND A limited number of studies have demonstrated that sleeping in the left lateral decubitus(LLD)decreases nocturnal reflux in patients with gastroesophageal reflux disease(GERD)compared to right lateral decub...BACKGROUND A limited number of studies have demonstrated that sleeping in the left lateral decubitus(LLD)decreases nocturnal reflux in patients with gastroesophageal reflux disease(GERD)compared to right lateral decubitus(RLD)and supine.AIM This systematic review summarizes the association between sleeping in the LLD position and nocturnal reflux in patients with GERD.METHODS Studies published up to July 17,2023,in MEDLINE,EMBASE,and CENTRAL were searched.Eligible studies were randomized and nonrandomized studies assessing the effect of sleeping in LLD compared to RLD and supine in reducing nocturnal reflux in GERD patients.Outcomes include the acid exposure time(AET)(%time in pH<4),acid clearance time(ACT)(in sec/episode),number of reflux episodes,and improvement in N-GSSIQ scores.RESULTS Two nonrandomized studies showed decreased AET and ACT in LLD sleep position in comparison to RLD(mean difference[MD]-2.03[95%CI:-3.62 to-0.45];-81.84[95%CI:-127.48 to-36.20],respectively)and supine position(MD-2.71[95%CI:-4.34 to-1.09];-74.47[95%CI:-116.26 to-32.69],respectively).There was no difference in AET and ACT between RLD sleep position and supine.Furthermore,one randomized controlled trial investigating the use of electronic sleep positional therapy,which increased the duration of LLD sleep and decreased the duration of RLD sleep compared to sham,showed nocturnal symptoms improvement(improved N-GSSIQ score,increased reflux-free nights,and resolution of nocturnal reflux symptoms).CONCLUSION Current evidence suggests that sleeping on the left side could reduce nocturnal reflux and improve GERD-related quality of life,therefore warranting interventions that promote LLD sleep position.展开更多
文摘目的 探讨睡眠体位及相关因素对中重度阻塞性睡眠呼吸暂停(OSA)患者日间过度嗜睡(excessive daytime sleepiness,EDS)严重程度的影响。方法 选取2020年10月~2022年9月在临沂市人民医院睡眠中心收治的106例中重度OSA患者,其中男性91例,女性15例,所有患者均行多导睡眠监测(PSG)。根据Epworth嗜睡量表(ESS)评分将其分为三组,非EDS组48例(ESS≤10分),轻中度EDS组34例(10分<ESS<17分)和重度EDS组24例(ESS≥17分)。分别比较三组患者的一般资料、睡眠体位相关参数、PSG参数,并将组间比较差异有意义的指标与ESS评分行相关性分析,二元logistic回归分析影响中重度OSA患者EDS程度的危险因素。结果 一般资料组间比较,体质量指数(BMI)、颈围和高血压方面差异具有统计学意义(F=3.607、7.797、χ2=8.690,P均<0.05)。其中轻中度组的颈围大于非EDS组,重度组的颈围及BMI均大于非EDS组(P均<0.05)。睡眠体位及PSG参数组间比较,仰卧位AHI、非仰卧位AHI、体位依赖性指数、AHI、非快速动眼期呼吸暂停低通气指数(NREM-AHI)、氧饱和度低于90%的百分比(percentage of total sleep time with oxygen saturation below90%,CT90%)、氧减饱和度指数(ODI)和微觉醒指数(micro-arousal index,MAI)差异有统计学意义(F=3.623、7.892、4.699、5.045、4.779、9.746、5.628、4.913,P均<0.05)。其中轻中度组和重度组的仰卧位AHI、非仰卧位AHI、CT90%、ODI、MAI、NREM-AHI、AHI均高于非EDS组(P均<0.05);重度组的体位依赖性指数显著低于非EDS组,且CT90%高于轻中度组(P均<0.05)。三组患者的ESS评分与仰卧位AHI、非仰卧位AHI、CT90%、ODI、MAI、NREM-AHI、AHI、BMI、颈围、高血压等指标均呈正相关关系(r=0.201、0.332、0.421、0.301、0.273、0.292、0.305、0.211、0.389、0.294,P均<0.05),与体位依赖性指数呈负相关关系(r=-0.282,P<0.05)。多因素分析显示:MAI是轻中度EDS组发病的独立危险因素(OR=1.036,P<0.05),颈围是重度E
文摘目的分析睡眠时头部转动方向对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者严重程度的影响,并探讨仰卧位时将头部转向一侧的侧头位简称仰卧头侧转位(trunk supine-head lateral,TSHL)时睡眠呼吸暂停低通气指数(AHI)明显改善的患者临床特征。方法整夜多道睡眠图监测确诊为OSAHS且未经治疗的180例患者,男性140例,女性40例。根据同步视频监测将睡眠时仰卧位进一步分为TSHL和头部与躯干姿势一致的仰头位简称仰卧仰头位(trunk supine-head supine,TSHS)。比较患者在不同头部姿势下AHI的变化规律,并分析TSHL较TSHS的AHI明显改善患者临床特征。结果TSHL的AHI较TSHS降低,58.8[32.4,76.0]次/h vs 50.7[19.5,75.2]次/h(Z=-4.670,P<0.001),88例(48.9%)患者AHI明显改善,92例(51.1%)患者改善不明显,33.0[16.9,48.6]次/h vs 56.3[21.7,68.8]次/h(P=0.003)。仰卧位AHI是TSHL病情改善程度的独立预测因子(P=0.014),体位依赖性(仰卧位AHI为侧卧位2倍以上)患者,TSHL的AHI改善比例更高(χ^(2)=5.844,P=0.016)。结论仰卧位时,向一侧转头可以改善部分患者病情。TSHL能否改善AHI与患者的病情严重程度有关,轻度OSAHS患者更可能通过头位的变化获益。
文摘BACKGROUND A limited number of studies have demonstrated that sleeping in the left lateral decubitus(LLD)decreases nocturnal reflux in patients with gastroesophageal reflux disease(GERD)compared to right lateral decubitus(RLD)and supine.AIM This systematic review summarizes the association between sleeping in the LLD position and nocturnal reflux in patients with GERD.METHODS Studies published up to July 17,2023,in MEDLINE,EMBASE,and CENTRAL were searched.Eligible studies were randomized and nonrandomized studies assessing the effect of sleeping in LLD compared to RLD and supine in reducing nocturnal reflux in GERD patients.Outcomes include the acid exposure time(AET)(%time in pH<4),acid clearance time(ACT)(in sec/episode),number of reflux episodes,and improvement in N-GSSIQ scores.RESULTS Two nonrandomized studies showed decreased AET and ACT in LLD sleep position in comparison to RLD(mean difference[MD]-2.03[95%CI:-3.62 to-0.45];-81.84[95%CI:-127.48 to-36.20],respectively)and supine position(MD-2.71[95%CI:-4.34 to-1.09];-74.47[95%CI:-116.26 to-32.69],respectively).There was no difference in AET and ACT between RLD sleep position and supine.Furthermore,one randomized controlled trial investigating the use of electronic sleep positional therapy,which increased the duration of LLD sleep and decreased the duration of RLD sleep compared to sham,showed nocturnal symptoms improvement(improved N-GSSIQ score,increased reflux-free nights,and resolution of nocturnal reflux symptoms).CONCLUSION Current evidence suggests that sleeping on the left side could reduce nocturnal reflux and improve GERD-related quality of life,therefore warranting interventions that promote LLD sleep position.
