The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent years.Sleep disorders are emerging risk factors for cardiovascular disease and have been relate...The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent years.Sleep disorders are emerging risk factors for cardiovascular disease and have been related to the whole spectrum of stroke,including transient ischemic attack,ischemic cerebral infarction and intracerebral haemorrhage.It has been shown that lacunar stroke or lacunar infarctions affecting the internal capsule or the protuberance are associated with a higher frequency of SDB.Acute stroke patients with associated SDB have a worse prognosis and a higher mortality as compared to patients with first-ever stroke without SDB.Preliminary studies provide evidence of the usefulness of treatment with continuous positive airway pressure when SDB is present in stroke patients.展开更多
Objective:Published research in obstructive sleep apnea (OSA) appears limited despite OSA being a highly prevalent adult and pediatric disease leading to many adverse outcomes if left untreated.We aimed to quantify th...Objective:Published research in obstructive sleep apnea (OSA) appears limited despite OSA being a highly prevalent adult and pediatric disease leading to many adverse outcomes if left untreated.We aimed to quantify the deficit in OSA scientific literature in order to provide a novel way of identifying gaps in knowledge and a need for further research inquiry.Mlethods:This was a Bibliometric analysis study.Using Ovid Medline database we analyzed and compared research output (medical and surgical) between adult OSA and similarly prevalent chronic conditions (Type Ⅱ diabetes (T2DM),coronary artery disease (CAD) and osteoarthritis (OA)) from December 2016 up to fifty years prior.Linear graphs were utilized to trend collected data.Utilizing same strategy,we compared publication trends for pediatric OSA to asthma and gastroesophageal reflux (GER).Results:Adult OSA publications (n =9314) were significantly underrepresented when compared to T2DM (n =66,023),CAD (n =31,526) and OA (n =34,123).Linear plots demonstrated that despite increasing number of publications this disparity persisted annually.Surgical literature composed 10.4％ (n =972) of adult OSA publications and reached a plateau in the last ten years.Pediatric OSA (n =2994) had less research output when compared to asthma (n =47,442) and GER (n =6705).However,over past five years pediatric OSA surpassed GER in annual number of publications.Surgical literature represented 23.1％ (n =693) of pediatric OSA publications and continued increasing over past ten years.Study methodologies for both adult and pediatric OSA showed a lack of randomized controlled trials and meta-analyses in comparison to other diseases.Conclusion:Our review shows substantial deficit in total,annual and surgical adult OSA published research compared to similarly prevalent diseases.This trend is not entirely observed in pediatric OSA literature.展开更多
目的探讨睡眠障碍性呼吸对老年脑梗死血压变异性及短期预后的影响。方法前瞻性纳入2012-06-2019-09在郑州人民医院神经内科二病区住院就诊的老年脑梗死患者226例。按照入院时及入院72 h NIHSS评分结果,按照是否发生终点事件分为进展组...目的探讨睡眠障碍性呼吸对老年脑梗死血压变异性及短期预后的影响。方法前瞻性纳入2012-06-2019-09在郑州人民医院神经内科二病区住院就诊的老年脑梗死患者226例。按照入院时及入院72 h NIHSS评分结果,按照是否发生终点事件分为进展组和对照组。入院后完成多导睡眠监测及动态血压监测。观察血压变异性及预后的差异,并分层分析不同睡眠紊乱指数下的血压变异性差异。结果进展组与对照组SE、TST、S3+S4/%、REM期睡眠比例及RDI、AHI、收缩压标准差比较,差异有统计学意义(P<0.05)。中高度睡眠呼吸紊乱指数组与对照组比较,高收缩压标准差、非杓型比例明显增多,差异有统计学意义(P<0.05)。结论睡眠呼吸暂停低通气指数、睡眠紊乱指数是预测睡眠障碍性呼吸老年脑梗死患者短期预后的可靠指标,原因可能与睡眠影响血压变异性有关。展开更多
文摘The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent years.Sleep disorders are emerging risk factors for cardiovascular disease and have been related to the whole spectrum of stroke,including transient ischemic attack,ischemic cerebral infarction and intracerebral haemorrhage.It has been shown that lacunar stroke or lacunar infarctions affecting the internal capsule or the protuberance are associated with a higher frequency of SDB.Acute stroke patients with associated SDB have a worse prognosis and a higher mortality as compared to patients with first-ever stroke without SDB.Preliminary studies provide evidence of the usefulness of treatment with continuous positive airway pressure when SDB is present in stroke patients.
文摘Objective:Published research in obstructive sleep apnea (OSA) appears limited despite OSA being a highly prevalent adult and pediatric disease leading to many adverse outcomes if left untreated.We aimed to quantify the deficit in OSA scientific literature in order to provide a novel way of identifying gaps in knowledge and a need for further research inquiry.Mlethods:This was a Bibliometric analysis study.Using Ovid Medline database we analyzed and compared research output (medical and surgical) between adult OSA and similarly prevalent chronic conditions (Type Ⅱ diabetes (T2DM),coronary artery disease (CAD) and osteoarthritis (OA)) from December 2016 up to fifty years prior.Linear graphs were utilized to trend collected data.Utilizing same strategy,we compared publication trends for pediatric OSA to asthma and gastroesophageal reflux (GER).Results:Adult OSA publications (n =9314) were significantly underrepresented when compared to T2DM (n =66,023),CAD (n =31,526) and OA (n =34,123).Linear plots demonstrated that despite increasing number of publications this disparity persisted annually.Surgical literature composed 10.4％ (n =972) of adult OSA publications and reached a plateau in the last ten years.Pediatric OSA (n =2994) had less research output when compared to asthma (n =47,442) and GER (n =6705).However,over past five years pediatric OSA surpassed GER in annual number of publications.Surgical literature represented 23.1％ (n =693) of pediatric OSA publications and continued increasing over past ten years.Study methodologies for both adult and pediatric OSA showed a lack of randomized controlled trials and meta-analyses in comparison to other diseases.Conclusion:Our review shows substantial deficit in total,annual and surgical adult OSA published research compared to similarly prevalent diseases.This trend is not entirely observed in pediatric OSA literature.
文摘目的探讨睡眠障碍性呼吸对老年脑梗死血压变异性及短期预后的影响。方法前瞻性纳入2012-06-2019-09在郑州人民医院神经内科二病区住院就诊的老年脑梗死患者226例。按照入院时及入院72 h NIHSS评分结果,按照是否发生终点事件分为进展组和对照组。入院后完成多导睡眠监测及动态血压监测。观察血压变异性及预后的差异,并分层分析不同睡眠紊乱指数下的血压变异性差异。结果进展组与对照组SE、TST、S3+S4/%、REM期睡眠比例及RDI、AHI、收缩压标准差比较,差异有统计学意义(P<0.05)。中高度睡眠呼吸紊乱指数组与对照组比较,高收缩压标准差、非杓型比例明显增多,差异有统计学意义(P<0.05)。结论睡眠呼吸暂停低通气指数、睡眠紊乱指数是预测睡眠障碍性呼吸老年脑梗死患者短期预后的可靠指标,原因可能与睡眠影响血压变异性有关。
