摘要
目的通过事件相关电位(event-related potential,ERP)探讨睡眠呼吸障碍儿童数学认知功能的特征。方法 2020年10月至2022年10月,选取8~11岁学龄期睡眠呼吸障碍(sleep disordered breathing,SDB)儿童及正常儿童各22例,进行加减乘计算及答案判断的数学任务,记录计算及判断过程中ERP及行为学数据,使用Matlab测量Fz导联N1、P2、N2、P3潜伏期和波幅进行分析比较。采用SPSS 23.0软件进行统计分析,两独立样本数据采用t检验或Mann-WhitneyU检验。结果 (1)SDB儿童与正常儿童行为学比较:两组在正确率的类型与组别的交互效应、组别的主效应、类型的主效应均不显著(F=0.470,3.590,0.003,均P>0.05);两组在反应时间的类型与组别的交互效应、组别的主效应均不显著(F=0.465,1.991,均P>0.05),类型的主效应显著(F=18.010,P<0.05)。(2)SDB儿童与正常儿童ERP比较:加法计算中SDB组的N2、P3潜伏期长于正常组[N2:(371.38±34.23)ms,(348.12±26.34)ms;P3:(610.72±64.78)ms,(529.05±30.25)ms](t=2.526,5.358,均P<0.05);减法计算中SDB组ERP潜伏期及波幅与正常组比较均差异无统计学意义(均P>0.05);乘法计算中SDB组的N2、P3潜伏期长于正常组[N2:(439.20±24.28)ms,(351.14±25.26)ms;P3:(531.71±35.42)ms,(415.23±19.01)ms](t=11.792,13.590,均P<0.05),SDB组的P3波幅高于正常组[P3:(3.16±4.78)μV,(0.38±3.27)μV](t=2.248,P<0.05)。正确判断中SDB组的P3潜伏期长于正常组[P3:(420.38±34.79)ms,(398.54±33.71)ms](t=2.115,P<0.05);错误判断中SDB组的P3潜伏期长于正常组[P3:(475.25±51.11)ms,(414.88±27.53)ms](t=4.878,P<0.05)。结论 SDB儿童ERP中N2、P3潜伏期延长,P3潜伏期比N2更为敏感,提示其存在数学认知功能的损害,且早于行为学(反应时间与正确率)出现变化,可作为早期评估SDB儿童数学认知功能损害的电生理学指标之一。
Objective To study the characteristics of mathematical cognitive function in children with sleep-disordered breathing(SDB)by event-related potential(ERP).Methods From October 2020 to October 2022,totally 22 cases of SDB children and 22 cases of normal children aged 8-11 were selected.All subjects performed mathematic tasks including calculating and deciding.The EEG changes and behavioral data of children with SDB and normal children were recorded.The latency and amplitude of N1,P2,N2,P3 in leads Fz were measured and compared by Matlab.SPSS 23.0 software was used for statistical analysis,and t test or Mann Whitney U test were used for two independent sample data.Results(1)Behavior test:the interaction effect between group and type,the group main effect,and the type main effect in accuracy between SDB group and normal group were not significant(F=0.470,3.590,0.003,all P>0.05).The group main effect and interaction effect between group and type in reaction time between SDB group and normal group were not significant(F=0.465,1.991,both P>0.05),while the type main effect was significant(F=18.010,P<0.05).(2)ERP test:the N2,P3 latencies for addition in children with SDB were longer than those in normal group(N2:(371.38±34.23)ms vs(348.12±26.34)ms;P3:(610.72±64.78)ms vs(529.05±30.25)ms)(t=2.526,5.358,both P<0.05).There was no significant difference between SDB group and normal group in ERP latency and amplitude for subtraction(both P>0.05).The N2,P3 latencies for multiplication in children with SDB were longer than those in normal group(N2:(439.20±24.28)ms vs(351.14±25.26)ms;P3:(531.71±35.42)ms vs(415.23±19.01)ms)(t=11.792,13.590,both P<0.05).The P3 amplitudes in children with SDB was higher than that in normal group(P3:(3.16±4.78)μV vs(0.38±3.27)μV)(t=2.248,P<0.05).The P3 latency for correct judgment in children with SDB was longer than that in normal group(P3:(420.38±34.79)ms vs(398.54±33.71)ms)(t=2.115,P<0.05).The P3 latency for wrong judgment in children with SDB was longer than that in normal group(P3:(
作者
史刘伟
王超群
梅海天
赵方乔
易阳
Shi Liuwei;Wang Chaoqun;Mei Haitian;Zhao Fangqiao;Yi Yang(Respiratory Department,the Affiliated Changzhou Children's Hospital of Nantong University,Changzhou 213003,China;Healthy Research Center,the Affiliated Changzhou Children's Hospital of Nantong University,Changzhou 213003,China;Developmental Behavioral Department,the Affiliated Changzhou Children's Hospital of Nantong University,Changzhou 213003,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2023年第9期822-827,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
常州市应用基础研究计划(CJ20220144)。
关键词
睡眠呼吸障碍
儿童
数学计算
数学认知
事件相关电位
Sleep disordered breathing
Children
Mathematical calculation
Mathematical cognition
Event related potential
