Chlorine-based sanitizers have seen wide spread use in food sanitation. The reaction of chlorine species with organic matter is a concern for two reasons. Available chlorine can be “used up” by organic compounds res...Chlorine-based sanitizers have seen wide spread use in food sanitation. The reaction of chlorine species with organic matter is a concern for two reasons. Available chlorine can be “used up” by organic compounds resulting in a lower amount of chlorine available for disinfection. Another concern is that some forms of chlorine can react with some organic compounds to form toxic halogenated disinfection byproducts（DBPs）. Many studies have been conducted to evaluate the role of hypochlorous acid（HOCl） and hypochlorite ion（OCl–） in the production of DBPs with a particular interest in the production of trihalomethanes（THMs） and haloacetic acids（HAAs）. Since most of the chlorine reactions are pH dependent, pH is found to have a significant effect on the formation of chlorine DBPs. In many cases, the concentration of THMs decreases and HAAs increases as pH decreases. pH also plays an important role in the determination of the type and amount of DBPs formed, with lower, more acidic, pHs resulting in the formation of less chloroform. This review summarizes the information from the literature on the role of chlorine-based sanitizers as affected by pH in the formation of different types of DBPs. Alternative novel strategies to minimize the formation of DBPs are also discussed.展开更多
Piroctone olamine(OCT) was used as the main bacteriostatic component, the inhibition of OCT in different kinds and mass concentrations of surfactants were studied. Six surfactants commonly used in personal care produc...Piroctone olamine(OCT) was used as the main bacteriostatic component, the inhibition of OCT in different kinds and mass concentrations of surfactants were studied. Six surfactants commonly used in personal care products, i.e. sodium laureth sulfate(AES), cocamidopropyl betaine(CAB 35), sodium lauroyl sarcosinate(LS-30), sodium lauroyl glutamate(ULS-30S), alkyl glycoside(APG), cocamide methyl MEA(CMMEA),were used. The results showed that the bacteriostatic of OCT decreased with the increase of AES, which was suggested ≤ 5%. OCT has good bacteriostatic performance in the systems of amino acid surfactants and high dosage of amphoteric surfactants, 5% LS 30 and ≥ 10% CAB 35 was recommended. High dosage of nonionic surfactant could interfere the bacteriostatic performance of OCT, the recommended dosage was ≤ 2%.In addition, OCT has good bacteriostatic performance against Staphylococcus aureus, Escherichia coli and Candida albicans when pH was controlled less than 5.5.展开更多
Background: Hand sanitizers are an important preventive measure to halt the spread of pathogens, which has become a huge demand during the coronavirus disease (COVID-19). Consequently, their safety and quality are top...Background: Hand sanitizers are an important preventive measure to halt the spread of pathogens, which has become a huge demand during the coronavirus disease (COVID-19). Consequently, their safety and quality are top priorities for regulatory organizations. Methods: Saudi Food & Drug Authority laboratories have analyzed numerous samples of hand sanitizers in order to ensure their safety and efficacy. Active ingredients, as well as hazardous impurities, have been checked according to the pharmacopeia. Results: In this study, we report the results of the analysis of 1409 samples, which represent the majority of products available in the Saudi Arabian market. The results showed that 196 samples (13.9%) did not meet international standards. Specifically, out of 196 failed samples, 75, 12, and 4 products contained hazardous substances such as methanol, 1-propanol, and acetaldehyde, respectively. Additionally, some failed samples contained foreign particles, were improperly labeled, or contained an inadequate concentration of alcohol. Conclusion: The substandard hand sanitizers possess a risk to the community, particularly during pandemics, and hence stringent yet dynamic regulations should be implemented.展开更多
Objective: To study the effects of some common additives on the antimicrobial activities of alcohol-based hand sanitizers. Methods: The antibacterial activities of varying aqueous concentrations of ethanol and isoprop...Objective: To study the effects of some common additives on the antimicrobial activities of alcohol-based hand sanitizers. Methods: The antibacterial activities of varying aqueous concentrations of ethanol and isopropyl alcohol were tested by the agar well diffusion method. The influences of different concentrations of glycerin was similarly tested. Finally, isopropyl alcohol and benzalkonium chloride were combined in different ratios within the sate use concentrations of each, and the effects of these combinations were compared with values obtained for the two agents used alone. Statistical methods, such as student t test and one-way ANOVA were used when appropriate to evaluate the differences in activity. Results: The activities of the alcohols showed marked concentration dependence, and both showed peak activity at 85%-95% concentration range. Over the concentration range of 60%-100%, isopropyl alcohol inhibited more bacterial and fungal organisms than ethanol, though the inhibition zone diameters it produced were not statistically different from those of ethanol for organisms which were sensitive to both of them.Addition of glycerin reduced the antimicrobial activities of the isopropyl alcohol, as shown by reduction in the inhibition zone diameters produced in vitro, which may be due to reduced drug diffusion with increase in viscosity. Addition of benzalkonium to isopropyl alcohol systems improved the activity of the alcohol, but the overall activity of the combination was not superior to that seen in the use of benzalkonium alone. Conclusion: Alcohol-based hand sanitizers should not be used outside the concentration range of 85%-95% and isopropyl alcohol inhibits more bacterial and fungal organisms than ethanol for most concentrations. Inclusion of benzalkonium improves the antimicrobial spectrum and activity of isopropyl alcohol, and the combination may justifiably be used to achieve both immediate and long lasting effect. Glycerin may adversely affect the antimicrobial activities of isopropyl alcohol-base展开更多
More than 85%of the currently marketed hand sanitizer products are alcohol-based products,and the alcohol content is usually about 70%in order to be effective.The high alcohol content can cause dehydration,which is un...More than 85%of the currently marketed hand sanitizer products are alcohol-based products,and the alcohol content is usually about 70%in order to be effective.The high alcohol content can cause dehydration,which is undesirable for sensitive skin,particularly for children.This creates opportunities for the development of innovative hand sanitizer products that are free of alcohol and have green nano-cellulose-based materials as carriers for the antibacterial agents.Good skin affinity and biocompatibility are the special features of the newly developed products,which would satisfy the need of the general public for green products.展开更多
文摘Chlorine-based sanitizers have seen wide spread use in food sanitation. The reaction of chlorine species with organic matter is a concern for two reasons. Available chlorine can be “used up” by organic compounds resulting in a lower amount of chlorine available for disinfection. Another concern is that some forms of chlorine can react with some organic compounds to form toxic halogenated disinfection byproducts（DBPs）. Many studies have been conducted to evaluate the role of hypochlorous acid（HOCl） and hypochlorite ion（OCl–） in the production of DBPs with a particular interest in the production of trihalomethanes（THMs） and haloacetic acids（HAAs）. Since most of the chlorine reactions are pH dependent, pH is found to have a significant effect on the formation of chlorine DBPs. In many cases, the concentration of THMs decreases and HAAs increases as pH decreases. pH also plays an important role in the determination of the type and amount of DBPs formed, with lower, more acidic, pHs resulting in the formation of less chloroform. This review summarizes the information from the literature on the role of chlorine-based sanitizers as affected by pH in the formation of different types of DBPs. Alternative novel strategies to minimize the formation of DBPs are also discussed.
文摘Piroctone olamine(OCT) was used as the main bacteriostatic component, the inhibition of OCT in different kinds and mass concentrations of surfactants were studied. Six surfactants commonly used in personal care products, i.e. sodium laureth sulfate(AES), cocamidopropyl betaine(CAB 35), sodium lauroyl sarcosinate(LS-30), sodium lauroyl glutamate(ULS-30S), alkyl glycoside(APG), cocamide methyl MEA(CMMEA),were used. The results showed that the bacteriostatic of OCT decreased with the increase of AES, which was suggested ≤ 5%. OCT has good bacteriostatic performance in the systems of amino acid surfactants and high dosage of amphoteric surfactants, 5% LS 30 and ≥ 10% CAB 35 was recommended. High dosage of nonionic surfactant could interfere the bacteriostatic performance of OCT, the recommended dosage was ≤ 2%.In addition, OCT has good bacteriostatic performance against Staphylococcus aureus, Escherichia coli and Candida albicans when pH was controlled less than 5.5.
文摘Background: Hand sanitizers are an important preventive measure to halt the spread of pathogens, which has become a huge demand during the coronavirus disease (COVID-19). Consequently, their safety and quality are top priorities for regulatory organizations. Methods: Saudi Food & Drug Authority laboratories have analyzed numerous samples of hand sanitizers in order to ensure their safety and efficacy. Active ingredients, as well as hazardous impurities, have been checked according to the pharmacopeia. Results: In this study, we report the results of the analysis of 1409 samples, which represent the majority of products available in the Saudi Arabian market. The results showed that 196 samples (13.9%) did not meet international standards. Specifically, out of 196 failed samples, 75, 12, and 4 products contained hazardous substances such as methanol, 1-propanol, and acetaldehyde, respectively. Additionally, some failed samples contained foreign particles, were improperly labeled, or contained an inadequate concentration of alcohol. Conclusion: The substandard hand sanitizers possess a risk to the community, particularly during pandemics, and hence stringent yet dynamic regulations should be implemented.
文摘Objective: To study the effects of some common additives on the antimicrobial activities of alcohol-based hand sanitizers. Methods: The antibacterial activities of varying aqueous concentrations of ethanol and isopropyl alcohol were tested by the agar well diffusion method. The influences of different concentrations of glycerin was similarly tested. Finally, isopropyl alcohol and benzalkonium chloride were combined in different ratios within the sate use concentrations of each, and the effects of these combinations were compared with values obtained for the two agents used alone. Statistical methods, such as student t test and one-way ANOVA were used when appropriate to evaluate the differences in activity. Results: The activities of the alcohols showed marked concentration dependence, and both showed peak activity at 85%-95% concentration range. Over the concentration range of 60%-100%, isopropyl alcohol inhibited more bacterial and fungal organisms than ethanol, though the inhibition zone diameters it produced were not statistically different from those of ethanol for organisms which were sensitive to both of them.Addition of glycerin reduced the antimicrobial activities of the isopropyl alcohol, as shown by reduction in the inhibition zone diameters produced in vitro, which may be due to reduced drug diffusion with increase in viscosity. Addition of benzalkonium to isopropyl alcohol systems improved the activity of the alcohol, but the overall activity of the combination was not superior to that seen in the use of benzalkonium alone. Conclusion: Alcohol-based hand sanitizers should not be used outside the concentration range of 85%-95% and isopropyl alcohol inhibits more bacterial and fungal organisms than ethanol for most concentrations. Inclusion of benzalkonium improves the antimicrobial spectrum and activity of isopropyl alcohol, and the combination may justifiably be used to achieve both immediate and long lasting effect. Glycerin may adversely affect the antimicrobial activities of isopropyl alcohol-base
基金the National Natural Science Foundation of China(31501440)China Postdoctoral Science Foundation(2015M571269)+1 种基金Tianjin Science and Technology Commissioner Program(16JCTPJC45300)Tianjin International Training Program for Excellent Postdoctoral Fellows of 2015.
文摘More than 85%of the currently marketed hand sanitizer products are alcohol-based products,and the alcohol content is usually about 70%in order to be effective.The high alcohol content can cause dehydration,which is undesirable for sensitive skin,particularly for children.This creates opportunities for the development of innovative hand sanitizer products that are free of alcohol and have green nano-cellulose-based materials as carriers for the antibacterial agents.Good skin affinity and biocompatibility are the special features of the newly developed products,which would satisfy the need of the general public for green products.
