Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were colle...Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were collected: (1) 43 men attending an infertility clinic, and (2) 51 men drawn from the general population without regard to fertility. Results: In sample (1) there were negative associations between 2D:4D and testicular function, and men with lower 2D:4D in their right compared to left hand had higher testosterone levels than men with higher 2D:4D in their right compared to left hand. Sample (2) showed no significant associations between 2D:4D or side differences in 2E>:4D and testosterone. Conclusion: Adult levels of testosterone may be related to aspects of 2D:4D in samples which contain men with compromised testicular function, but not in men from normative samples. Associations between 2D:4D and fertility-associated traits probably arise from early organisational effects of testosterone rather than from activational effects of current testosterone.展开更多
研究人类第二根手指长度(second finger length,2D)与第四根手指长度(fourth fingerlength,4D)的比率(digit ratio of 2D and 4D,2D:4D)与运动能力遗传存在相关性。结果显示,2D:4D在出生前就已经定型,其与母亲子宫睾酮浓度及成年后睾酮...研究人类第二根手指长度(second finger length,2D)与第四根手指长度(fourth fingerlength,4D)的比率(digit ratio of 2D and 4D,2D:4D)与运动能力遗传存在相关性。结果显示,2D:4D在出生前就已经定型,其与母亲子宫睾酮浓度及成年后睾酮浓度存在着负相关。睾酮浓度会影响大脑右半球和空间视觉能力的发育,从而影响运动能力。展开更多
An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-...An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-2-yl）quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.展开更多
5,6-Dihydrothieno[3＇,2＇：4,5]thieno[2,3-d]pyrimidin-4（3H）-ones 6 were synthesized in yields of 71-87% by a consecutive method, which includes aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to gi...5,6-Dihydrothieno[3＇,2＇：4,5]thieno[2,3-d]pyrimidin-4（3H）-ones 6 were synthesized in yields of 71-87% by a consecutive method, which includes aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various amines, phenols or alcohols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate. 2009 Ming Wu Ding. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
4,5-Dibromo-1-methyl-2-trichloroacetylpyrrole Ⅰ, prepared by the reaction of 1-methyl-2-trichloroacetylpyrrole with Br2 in 98.6 % yield, was condensed with methyl L-2-amino-3- phenylpropanoate to afford methyl 2-（4,...4,5-Dibromo-1-methyl-2-trichloroacetylpyrrole Ⅰ, prepared by the reaction of 1-methyl-2-trichloroacetylpyrrole with Br2 in 98.6 % yield, was condensed with methyl L-2-amino-3- phenylpropanoate to afford methyl 2-（4,5-dibromo-1-methylpyrrole-2-carboxmido）-3-phenylpropanoate Ⅱ in 90.8% yield. Crystal data for Ⅰ： monoclinic system, space group P21/c with a = 8.595（3）, b = 10.900（4）, c = 12.321（5） ,A°,β = 92.292（7）°, V = 1153.4（8）A°^3, Dc = 2.213 g/cm^3, F（000） = 728, CTH4Br2Cl3NO, Mr = 384.28, λ = 0.71073 A°, μ（MoKa） = 7.688 mm^-1, Z = 4, R = 0.0338 and wR2 = 0.0840 for 1963 observed reflections with I 〉 2a（I）. Crystal data for Ⅱ： monoclinic system, space group P21 with a = 4.886（2）, b = 15.921（8）, c = 11.635（6） A°,β = 101.803（9）°, V = 885.9（7） A°^3, Dc = 1.665 g/cm^3, F（000） = 440, C16H16Br2N2O3, Mr = 444.13, λ = 0.71073 A°, μ（MoKa） = 4.590 mm^-1, Z = 2, R = 0.0335 and wR2 = 0.0837 for 3191 observed reflections with I 〉 2σ（I）. The crystal structure reveals that compound Ⅱ forms the one-dimensional chain structure via the intermolecular hydrogen bonds of N（2）-H…O（1）.展开更多
目的探究食指和无名指长度的比值(2D∶4D)在精神分裂症患者和健康人群中的差异,并分析精神分裂症患者手指比值(2D∶4D)与精神症状的相关性。方法选取2019年7月至2020年8月芜湖市第四人民医院收治的136名精神分裂症患者作为患者组,同期...目的探究食指和无名指长度的比值(2D∶4D)在精神分裂症患者和健康人群中的差异,并分析精神分裂症患者手指比值(2D∶4D)与精神症状的相关性。方法选取2019年7月至2020年8月芜湖市第四人民医院收治的136名精神分裂症患者作为患者组,同期招募在该医院工作、学习及就诊患者家属148名健康人群作为对照组,利用Adobe Photoshop CC 19.1.3软件对两组被试者的手指照片进行测量,并采用阳性与阴性症状量表(PANSS)对精神分裂症患者的精神症状进行评定。比较两组被试者间手指比值的差异,采用Pearson相关分析患者组手指比值与精神症状的关联性。结果患者组右手的2D∶4D比值小于对照组;在不同性别中,患者组男性左右手的2D∶4D比值均大于对照组,患者组女性左右手的2D∶4D比值均小于对照组,差异有统计学意义(P<0.05)。对照组右手的2D∶4D比值大于左手,其中男性左右手的2D∶4D比值小于女性,差异均有统计学意义(P<0.05);而患者组左右手的2D∶4D比值,差异不具有统计学意义(P>0.05)。患者的左右手的2D∶4D比值与PANSS总分及各症状因子得分均不存在相关性(P>0.05)。结论精神分裂症患者的2D∶4D比值与其精神症状不存在相关性,但是存在异于健康人群的2D∶4D比值,这可能是精神分裂症的一个提示。展开更多
文摘Aim: To investigate the relationship between 2D:4D and testosterone in men attending an infertility clinic and men drawn from the general population. Methods: Data on 2D:4D and testosterone from two samples were collected: (1) 43 men attending an infertility clinic, and (2) 51 men drawn from the general population without regard to fertility. Results: In sample (1) there were negative associations between 2D:4D and testicular function, and men with lower 2D:4D in their right compared to left hand had higher testosterone levels than men with higher 2D:4D in their right compared to left hand. Sample (2) showed no significant associations between 2D:4D or side differences in 2E>:4D and testosterone. Conclusion: Adult levels of testosterone may be related to aspects of 2D:4D in samples which contain men with compromised testicular function, but not in men from normative samples. Associations between 2D:4D and fertility-associated traits probably arise from early organisational effects of testosterone rather than from activational effects of current testosterone.
文摘研究人类第二根手指长度(second finger length,2D)与第四根手指长度(fourth fingerlength,4D)的比率(digit ratio of 2D and 4D,2D:4D)与运动能力遗传存在相关性。结果显示,2D:4D在出生前就已经定型,其与母亲子宫睾酮浓度及成年后睾酮浓度存在着负相关。睾酮浓度会影响大脑右半球和空间视觉能力的发育,从而影响运动能力。
文摘An efficient method for the synthesis of novel benzo[b]pyrido[3＇,2＇：4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-（3-aminothieno[2,3-b]pyridin-2-yl）quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.
基金support of this work by the National Natural Science Foundation of China(No.20772041)Key Project of Science and Technology of Ministry of Education of China(No.107082)
文摘5,6-Dihydrothieno[3＇,2＇：4,5]thieno[2,3-d]pyrimidin-4（3H）-ones 6 were synthesized in yields of 71-87% by a consecutive method, which includes aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various amines, phenols or alcohols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate. 2009 Ming Wu Ding. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金The project was supported by the National 863 Program of China (No. 2004AA628030), and Natural Science Foundation of Guangdong Province (No. 31920)
文摘4,5-Dibromo-1-methyl-2-trichloroacetylpyrrole Ⅰ, prepared by the reaction of 1-methyl-2-trichloroacetylpyrrole with Br2 in 98.6 % yield, was condensed with methyl L-2-amino-3- phenylpropanoate to afford methyl 2-（4,5-dibromo-1-methylpyrrole-2-carboxmido）-3-phenylpropanoate Ⅱ in 90.8% yield. Crystal data for Ⅰ： monoclinic system, space group P21/c with a = 8.595（3）, b = 10.900（4）, c = 12.321（5） ,A°,β = 92.292（7）°, V = 1153.4（8）A°^3, Dc = 2.213 g/cm^3, F（000） = 728, CTH4Br2Cl3NO, Mr = 384.28, λ = 0.71073 A°, μ（MoKa） = 7.688 mm^-1, Z = 4, R = 0.0338 and wR2 = 0.0840 for 1963 observed reflections with I 〉 2a（I）. Crystal data for Ⅱ： monoclinic system, space group P21 with a = 4.886（2）, b = 15.921（8）, c = 11.635（6） A°,β = 101.803（9）°, V = 885.9（7） A°^3, Dc = 1.665 g/cm^3, F（000） = 440, C16H16Br2N2O3, Mr = 444.13, λ = 0.71073 A°, μ（MoKa） = 4.590 mm^-1, Z = 2, R = 0.0335 and wR2 = 0.0837 for 3191 observed reflections with I 〉 2σ（I）. The crystal structure reveals that compound Ⅱ forms the one-dimensional chain structure via the intermolecular hydrogen bonds of N（2）-H…O（1）.
文摘目的探究食指和无名指长度的比值(2D∶4D)在精神分裂症患者和健康人群中的差异,并分析精神分裂症患者手指比值(2D∶4D)与精神症状的相关性。方法选取2019年7月至2020年8月芜湖市第四人民医院收治的136名精神分裂症患者作为患者组,同期招募在该医院工作、学习及就诊患者家属148名健康人群作为对照组,利用Adobe Photoshop CC 19.1.3软件对两组被试者的手指照片进行测量,并采用阳性与阴性症状量表(PANSS)对精神分裂症患者的精神症状进行评定。比较两组被试者间手指比值的差异,采用Pearson相关分析患者组手指比值与精神症状的关联性。结果患者组右手的2D∶4D比值小于对照组;在不同性别中,患者组男性左右手的2D∶4D比值均大于对照组,患者组女性左右手的2D∶4D比值均小于对照组,差异有统计学意义(P<0.05)。对照组右手的2D∶4D比值大于左手,其中男性左右手的2D∶4D比值小于女性,差异均有统计学意义(P<0.05);而患者组左右手的2D∶4D比值,差异不具有统计学意义(P>0.05)。患者的左右手的2D∶4D比值与PANSS总分及各症状因子得分均不存在相关性(P>0.05)。结论精神分裂症患者的2D∶4D比值与其精神症状不存在相关性,但是存在异于健康人群的2D∶4D比值,这可能是精神分裂症的一个提示。
