气道阻抗的监测对肺功能疾病的准确评估及早期诊断具有重要临床价值。针对当前肺功能设备中振荡源系统体积大、功耗高等难以满足动态测量需求的问题,本研究采用可控呼气振荡与状态可视化反馈的新策略,设计了微型电磁振荡源、集成传感控...气道阻抗的监测对肺功能疾病的准确评估及早期诊断具有重要临床价值。针对当前肺功能设备中振荡源系统体积大、功耗高等难以满足动态测量需求的问题,本研究采用可控呼气振荡与状态可视化反馈的新策略,设计了微型电磁振荡源、集成传感控制电路和动态反馈系统,开发了一种结构轻巧、功耗低及带可视化状态反馈的气道阻抗监测系统。呼吸阻抗测量实验及统计对比结果表明,该系统可实现稳定的5 Hz气道阻抗测量,呼吸系统阻抗(R和X)频谱曲线与临床肺功能仪IOS的频谱曲线均具有较为一致的变化趋势,其差值均小于1.1 cm H_(2)O·s/L;运动与静息状态组的呼吸阻抗R5差异有统计学意义,且呼吸电抗X5的波动幅值较大,表明本系统能测量气道阻力参数的动态变异性。因此,本研究开发的阻抗监测系统支持受试者可手持移动、较长时间段内连续测量气道阻抗的动态变化,为进一步开发低功耗、便携化甚至可穿戴的动态肺功能监测设备提供了研究基础。展开更多
Objective: To observe the relationship of deep slow respiratory pattern and respiratory impedance(RI) in patients with chronic obstructive pulmonary disease (COPD). Methods: RI under normal respiration and during deep...Objective: To observe the relationship of deep slow respiratory pattern and respiratory impedance(RI) in patients with chronic obstructive pulmonary disease (COPD). Methods: RI under normal respiration and during deep slow respira tion was measured one after the other with impulse oscillometry for 8 patients with COPD and for 9 healthy volunteers as control. Results: When r espiration was changed from normal pattern to the deep slow pattern, the tida l volume increased and respiratory frequency significantly decreased in both gro ups , the total respiratory impedance (Z respir) showed a decreasing trend in COPD group, but with no obvious change in the control group. No chang e in the resonant frequency (fres) was found in both groups, and the respiratory viscous resistance obviously decreased in the COPD group(R5: P =0.0168 ; R20: P =0.0498; R5—R20: P =0.0388),though in the control group it was unchanged. Conclusion: IOS detection could reflect the response he terogeneity of different compartments of respiratory system during tidal breathi ng. During deep slow respiration, the viscous resistance in both central airw ay and peripheral airway was decreased in patients with COPD. RI measurement by impulse oscillometry may be a convenient pathophysiological method for studying the application of breathing exercise in patients with COPD.展开更多
文摘气道阻抗的监测对肺功能疾病的准确评估及早期诊断具有重要临床价值。针对当前肺功能设备中振荡源系统体积大、功耗高等难以满足动态测量需求的问题,本研究采用可控呼气振荡与状态可视化反馈的新策略,设计了微型电磁振荡源、集成传感控制电路和动态反馈系统,开发了一种结构轻巧、功耗低及带可视化状态反馈的气道阻抗监测系统。呼吸阻抗测量实验及统计对比结果表明,该系统可实现稳定的5 Hz气道阻抗测量,呼吸系统阻抗(R和X)频谱曲线与临床肺功能仪IOS的频谱曲线均具有较为一致的变化趋势,其差值均小于1.1 cm H_(2)O·s/L;运动与静息状态组的呼吸阻抗R5差异有统计学意义,且呼吸电抗X5的波动幅值较大,表明本系统能测量气道阻力参数的动态变异性。因此,本研究开发的阻抗监测系统支持受试者可手持移动、较长时间段内连续测量气道阻抗的动态变化,为进一步开发低功耗、便携化甚至可穿戴的动态肺功能监测设备提供了研究基础。
文摘Objective: To observe the relationship of deep slow respiratory pattern and respiratory impedance(RI) in patients with chronic obstructive pulmonary disease (COPD). Methods: RI under normal respiration and during deep slow respira tion was measured one after the other with impulse oscillometry for 8 patients with COPD and for 9 healthy volunteers as control. Results: When r espiration was changed from normal pattern to the deep slow pattern, the tida l volume increased and respiratory frequency significantly decreased in both gro ups , the total respiratory impedance (Z respir) showed a decreasing trend in COPD group, but with no obvious change in the control group. No chang e in the resonant frequency (fres) was found in both groups, and the respiratory viscous resistance obviously decreased in the COPD group(R5: P =0.0168 ; R20: P =0.0498; R5—R20: P =0.0388),though in the control group it was unchanged. Conclusion: IOS detection could reflect the response he terogeneity of different compartments of respiratory system during tidal breathi ng. During deep slow respiration, the viscous resistance in both central airw ay and peripheral airway was decreased in patients with COPD. RI measurement by impulse oscillometry may be a convenient pathophysiological method for studying the application of breathing exercise in patients with COPD.
