Cardiovascular disease is the most important factor that affect the lifetime of uremia patients. Recently, scientists pay closer attention to study the mechanism of cardiac injury in uremia patients. In this article, ...Cardiovascular disease is the most important factor that affect the lifetime of uremia patients. Recently, scientists pay closer attention to study the mechanism of cardiac injury in uremia patients. In this article, we will make an overview on mechanism of cardiac injure caused by uremia toxin, secondary hyperparathyroidism, calcium-phosphorus metabolic disorder, rennin-angiotensin-aldosterone system.展开更多
To investigate the protective effects of blocking rennin-angiotensin system(RAS)on the progression of renal injury in glomerulosclerosis,a glomerulosclerosis model was made for SD rats by unilateral nephrectomy and be...To investigate the protective effects of blocking rennin-angiotensin system(RAS)on the progression of renal injury in glomerulosclerosis,a glomerulosclerosis model was made for SD rats by unilateral nephrectomy and being injected with Adriamycin into caudal vein.The rats with glomerulosclerosis were randomly divided as ten per group into those without further treatment(group D)and those treated with Benazepril(group DB),Losartan (group DL),or sham-operation(group C),respectively.After 6 weeks of administration of Benazepril or Losartan, the mRNA expressions of TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS in renal cortex were measured by RT-PCR.Besides, the expressions of TGF-β_1,ET-1 and iNOS at protein level were detected by Western blotting and the concentrations of Col Ⅳ and Fn were analyzed with immunohistochemistry respectively.Results showed that the rats in group D appeared as obvious proteinuria,hypoalbuminemia and hypercholesterolemia,which had a significant difference compared with group C(p<0.05),and most of their mesangiums were detected with cellular proliferation and significant increasing for extracellular matrix.Renal cortex TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS in rats of group D were increased by 3.59,2.57,2.21,2.58 and 3.28 times at mRNA level,and by 2.60,1.40,0.75,1.83 and 2.15 times at protein level,respectively,compared with group C.When the animals were treated with Benazepril(group DB)or Losartan(group DL),however,the biochemical and pathological damages were significantly recovered,and protein expressions of TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS were also significantly diminished(p<0.05).This study suggested that blocking RAS using Benazepril or Losartan can have protective effects on the renal injury in glomerulosclerosis by down-regulating the expressions of TGF-β_1, Col Ⅳ,Fn,ET-1 and iNOS.Cellular & Molecular Immunology.2005;2(2):150-154.展开更多
目的运用Citespace软件对肾素-血管紧张素系统与心房颤动(房颤)关系的相关研究规律以可视化知识图谱的形式进行展示,以揭示该领域的研究方向、研究热点和研究前沿。方法以Web of Science核心合集数据库为数据来源,利用可视化分析软件Cit...目的运用Citespace软件对肾素-血管紧张素系统与心房颤动(房颤)关系的相关研究规律以可视化知识图谱的形式进行展示,以揭示该领域的研究方向、研究热点和研究前沿。方法以Web of Science核心合集数据库为数据来源,利用可视化分析软件Citespace5.4 R3对肾素血管紧张素系统与房颤关系相关研究进行可视化分析,探讨相关研究的文献分布、国家/机构分布、作者分布以及对共被引文献和关键词进行分析。结果共纳入503篇SCI文章,年度发文量和引文量总体呈现上升趋势;美国、中国、意大利、德国和日本为该领域研究的主要国家,加拿大蒙特利尔大学是该领域发文量最多的机构;发文量最高的作者是台湾大学的LIN JL及TSAI CT。主要的研究热点为房颤合并心力衰竭、心肌梗死研究,血管紧张素转化酶抑制剂或血管紧张素受体阻滞剂治疗房颤等研究。氧化应激在房颤发生中的作用,肾素血管紧张素抑制剂对心力衰竭、慢性肾病合并房颤的治疗作用,房颤的上游治疗药物的研究是肾素血管紧张素系统与房颤关系相关研究的前沿领域。结论本研究运用Citespace软件对肾素血管紧张素系统与房颤关系的相关研究规律以可视化知识图谱的形式进行展示,揭示该领域的研究方向、研究热点和研究前沿,为研究人员进一步的研究提供指引与参考。展开更多
文摘Cardiovascular disease is the most important factor that affect the lifetime of uremia patients. Recently, scientists pay closer attention to study the mechanism of cardiac injury in uremia patients. In this article, we will make an overview on mechanism of cardiac injure caused by uremia toxin, secondary hyperparathyroidism, calcium-phosphorus metabolic disorder, rennin-angiotensin-aldosterone system.
文摘To investigate the protective effects of blocking rennin-angiotensin system(RAS)on the progression of renal injury in glomerulosclerosis,a glomerulosclerosis model was made for SD rats by unilateral nephrectomy and being injected with Adriamycin into caudal vein.The rats with glomerulosclerosis were randomly divided as ten per group into those without further treatment(group D)and those treated with Benazepril(group DB),Losartan (group DL),or sham-operation(group C),respectively.After 6 weeks of administration of Benazepril or Losartan, the mRNA expressions of TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS in renal cortex were measured by RT-PCR.Besides, the expressions of TGF-β_1,ET-1 and iNOS at protein level were detected by Western blotting and the concentrations of Col Ⅳ and Fn were analyzed with immunohistochemistry respectively.Results showed that the rats in group D appeared as obvious proteinuria,hypoalbuminemia and hypercholesterolemia,which had a significant difference compared with group C(p<0.05),and most of their mesangiums were detected with cellular proliferation and significant increasing for extracellular matrix.Renal cortex TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS in rats of group D were increased by 3.59,2.57,2.21,2.58 and 3.28 times at mRNA level,and by 2.60,1.40,0.75,1.83 and 2.15 times at protein level,respectively,compared with group C.When the animals were treated with Benazepril(group DB)or Losartan(group DL),however,the biochemical and pathological damages were significantly recovered,and protein expressions of TGF-β_1,Col Ⅳ,Fn,ET-1 and iNOS were also significantly diminished(p<0.05).This study suggested that blocking RAS using Benazepril or Losartan can have protective effects on the renal injury in glomerulosclerosis by down-regulating the expressions of TGF-β_1, Col Ⅳ,Fn,ET-1 and iNOS.Cellular & Molecular Immunology.2005;2(2):150-154.
