It is the basic requirement of the synergetic exploitation of deep mineral resources and geothermal resources to arrange the heat transfer tube in filling body. The heat release performance of filling body directly im...It is the basic requirement of the synergetic exploitation of deep mineral resources and geothermal resources to arrange the heat transfer tube in filling body. The heat release performance of filling body directly impacts on the exploiting efficiency of geothermal energy. Based on heat transfer theory, a three-dimensional unsteady heat transfer model of filling body is established by using FLUENT simulation software. Taking the horizontal U-shaped buried pipe as research object, the variation of temperature field in filling body around buried pipe is analyzed during the heat release process of filling body;the initial temperature of filling body, the diameter of buried pipe, the inlet temperature and inlet velocity of heat transfer fluid influencing of coupling heat transfer, which exists between heat transfer fluid and surrounding filling body within a certain axial distance of buried tube, and influencing of temperature difference between inlet and outlet of heat transfer fluid and on heat transfer performance of filling body are also discussed. It not only lays a theoretical foundation for the synergetic exploitation of mineral resources and geothermal energy in deep mines, but also provides a reference basis for the arrangement of buried pipes in filling body as well as the selection of working conditions for heat transfer fluid.展开更多
Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are ...Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood diseases.In this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward ACMs.Effects of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in depth.And the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different pH values was systematically evaluated.The nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred process.Furthermore,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.展开更多
High-performance liquid chromatography （HPLC） was employed to determine drug release rates based on emamectin benzoate concentrations in the medium. Release kinetics equations were used to fit the drug release behav...High-performance liquid chromatography （HPLC） was employed to determine drug release rates based on emamectin benzoate concentrations in the medium. Release kinetics equations were used to fit the drug release behavior. The effects of particle size and release medium pH on the release rate were also investigated. The indoor toxicity of emamectin benzoate-loaded polylactic acid microspheres on the diamondback moth larva （Plutella xylostella） was studied to explore drug sustained-release performance. In acidic and neutral media, the drug release behavior of the microspheres was in accord with the first-order kinetics equation. Increasing the spray dosage of emamectin benzoate-loaded polylactic acid microspheres initially resulted in an equivalent insecticidal efficacy with the conventional emamectin benzoate microemulsion. However, the drug persistence period was four-fold longer than that observed using the conventional formulation. The developed emamectin benzoate-loaded polylactic acid microspheres showed dramatic sustained-release performance. A treatment threshold of greater than 35 mg mL-1 was established for an efficient accumulated release concentration of emamectin benzoate-loaded microspheres.展开更多
基金Projects(51974225,51874229,51674188,51904224,51904225,51504182) supported by the National Natural Science Foundation of ChinaProjects(2018JM5161,2018JQ5183,2015JQ5187) supported by the Natural Science Basic Research Plan of Shaanxi,China
文摘It is the basic requirement of the synergetic exploitation of deep mineral resources and geothermal resources to arrange the heat transfer tube in filling body. The heat release performance of filling body directly impacts on the exploiting efficiency of geothermal energy. Based on heat transfer theory, a three-dimensional unsteady heat transfer model of filling body is established by using FLUENT simulation software. Taking the horizontal U-shaped buried pipe as research object, the variation of temperature field in filling body around buried pipe is analyzed during the heat release process of filling body;the initial temperature of filling body, the diameter of buried pipe, the inlet temperature and inlet velocity of heat transfer fluid influencing of coupling heat transfer, which exists between heat transfer fluid and surrounding filling body within a certain axial distance of buried tube, and influencing of temperature difference between inlet and outlet of heat transfer fluid and on heat transfer performance of filling body are also discussed. It not only lays a theoretical foundation for the synergetic exploitation of mineral resources and geothermal energy in deep mines, but also provides a reference basis for the arrangement of buried pipes in filling body as well as the selection of working conditions for heat transfer fluid.
基金the National Natural Science Foundation of China(grant No.22178325).
文摘Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood diseases.In this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward ACMs.Effects of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in depth.And the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different pH values was systematically evaluated.The nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred process.Furthermore,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.
基金supported by the National Key Research and Development Program of China (2016YFD0200502, 2017YFD0200301)
文摘High-performance liquid chromatography （HPLC） was employed to determine drug release rates based on emamectin benzoate concentrations in the medium. Release kinetics equations were used to fit the drug release behavior. The effects of particle size and release medium pH on the release rate were also investigated. The indoor toxicity of emamectin benzoate-loaded polylactic acid microspheres on the diamondback moth larva （Plutella xylostella） was studied to explore drug sustained-release performance. In acidic and neutral media, the drug release behavior of the microspheres was in accord with the first-order kinetics equation. Increasing the spray dosage of emamectin benzoate-loaded polylactic acid microspheres initially resulted in an equivalent insecticidal efficacy with the conventional emamectin benzoate microemulsion. However, the drug persistence period was four-fold longer than that observed using the conventional formulation. The developed emamectin benzoate-loaded polylactic acid microspheres showed dramatic sustained-release performance. A treatment threshold of greater than 35 mg mL-1 was established for an efficient accumulated release concentration of emamectin benzoate-loaded microspheres.
