Background: Melasma has been shown to have a significant emotional and psychologic effect on affected patients. Although this pigmentary disorder is thought to be more prevalent among Latinos, the effect of melasma on...Background: Melasma has been shown to have a significant emotional and psychologic effect on affected patients. Although this pigmentary disorder is thought to be more prevalent among Latinos, the effect of melasma on quality of life (QOL) in this population is unknown. Objectives: The goals of this study were to translate and culturally adapt the previously validated Melasma QOL (MELASQOL) scale into Spanish language, to confirm the new scale’s reliability and validity,and to administer the scale to characterize melasma’ s effect on the health-related QOL of Spanish language-speaking Latino patients. Methods:Cross-cultural adaptation of the original questionnaire was performed using previously established guidelines. After pretesting the questionnaire in a group of 30 patients, it was tested in a group of 112 patients recruited from a community outpatient clinic. A Spanish-language health-related QOL assessment battery was also administered for validation purposes.The degree of melasma was determined on clinical examination by the investigator using the Melasma Area and Severity Index.Results: Cross-cultural adaptation of the questionnaire was successful in producing a working and understandable Spanish language version of the MELASQOL. The Spanish-language MELASQOL scale was internally reliable and demonstrated construct and content validity. The Spanish-language MELASQOL scores of patients with little to no formal education were significantly higher than those with at least a seventh-grade education.Scores were proportional to the length of time a patient had lived with melasma and were higher in patients who had previously sought treatment. Spanish-language MELASQOL score and Melasma Area and Severity Index were shown to be moderately correlated, but no differences were seen according to patient age, marital status, employment, or coexisting medical or psychiatric conditions. Limitations: Limitations area lack of data regarding socioeconomic status and limitation to Mexican and Central American female pat展开更多
Objectives. This study examines quality of life (QOL) among school-aged children with perinatally acquired HIV infection and compares QOL outcomes between treatment groups that differ according to the use of protease ...Objectives. This study examines quality of life (QOL) among school-aged children with perinatally acquired HIV infection and compares QOL outcomes between treatment groups that differ according to the use of protease inhibitor (PI) combination therapy (PI therapy). To gain insights into how PI therapy might influence QOL, associations between severity of illness and QOL were also investigated. Methods. Cross-sectional data for 940 children, 5 to 18 years of age, who were enrolled in Pediatric AIDS Clinical Trials Group Late Outcomes Protocol 219 were used to examine domains of caregiver-reported QOL, as assessed with the General Health Assessment for Children, during 1999. The General Health Assessment for Children is an age-specific, modular, QOL assessment that was developed for the study with previously validated measures. QOL differences between treatment groups were estimated with linear and logistic regressions that controlled for sociodemographic characteristics (age, gender, raceethnicity, maternalcaregiver education, and respondent) and severity-of-illness indicators related to receipt of PI therapy (AIDS status, log10 CD4+cell counts, and height-for-age z scores). Results. The mean age of participants was 9.7 years. Most children were non-Hispanic black (54%) or Hispanic (31%), and 49%of the participants were female. At the 1999 study visit, ～14%of children had severe immune suppression ( < 15%CD4+cells), whereas 62%of children had ≥25%CD4+cells, ie, no immune suppression. Participants did exhibit some lag in growth, with mean height and weight z scores of-0.70 and-0.20, respectively. Twentyeight percent of the children were reported to have met criteria for AIDS at study entry (1993-1999). When treatment groups were compared, children receiving PI therapy (72%) were older, had lower CD4 +cell percentages, and had lower height and weight z scores than did those receiving non-PI therapies. They were also more likely to have met criteria for AIDS at study entry. The most commonly used PIs were ritonav展开更多
目的:测定评价Mapi Research Trust授权的便秘患者生存质量自评量表PAC-QOL中文版的信度、效度和反应度.方法:通过测定283例罗马Ⅲ标准诊断的功能性便秘患者的生存质量对PAC-QOL中文版进行评价.结果:通过探索性因子分析,量表可分为生理...目的:测定评价Mapi Research Trust授权的便秘患者生存质量自评量表PAC-QOL中文版的信度、效度和反应度.方法:通过测定283例罗马Ⅲ标准诊断的功能性便秘患者的生存质量对PAC-QOL中文版进行评价.结果:通过探索性因子分析,量表可分为生理、社会心理、担忧和满意度4个公因子,与原版量表基本一致;各条目与其所属领域的相关性有显著统计学意义(P<0.01);各领域及总分的内在信度Cronbachα系数除生理维度为0.69外,其余均在0.70以上;治疗1mo后与治疗前相比,各维度得分和总分有显著统计学差异(P<0.01);便秘患者治疗前与健康人群相比,各维度得分和总分有显著统计学差异(P<0.01).结论:PAC-QOL中文版具有较好的信度、效度和反应度,可用于中国便秘患者生存质量的测定.展开更多
目的:汉化甲状腺癌特异性生命质量(yroid Cancer-specic Quality of Life,THYCA-QoL)量表,并对其进行信度和效度检验。方法:征得荷兰蒂尔堡大学HUSSON教授同意并获得量表授权,对英文版THYCA-QoL量表进行翻译、回译及文化调试,形成中文版...目的:汉化甲状腺癌特异性生命质量(yroid Cancer-specic Quality of Life,THYCA-QoL)量表,并对其进行信度和效度检验。方法:征得荷兰蒂尔堡大学HUSSON教授同意并获得量表授权,对英文版THYCA-QoL量表进行翻译、回译及文化调试,形成中文版THYCAQoL量表。采用中文版欧洲癌症研究与治疗组织生命质量核心量表C30(European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30,EORTC QLQ-C30)和THYCA-QoL量表对成都市3所三甲医院(四川省肿瘤医院、四川省人民医院和中国人民解放军西部战区总医院)336例甲状腺癌患者进行调查。其中106例患者于第一次测评后2～3 d,再次予以重测。采用Cronbach’sα系数评价量表的内部一致信度,采用重测相关系数r评价量表的重测信度。采用探索性因子分析评价量表的结构效度,采用条目-领域相关性分析评价量表的集合效度与区分效度。结果:中文版THYCA-QoL量表除神经肌肉领域(Cronbach’sα系数为0.671)和感官领域(Cronbach’sα系数为0.530)外,其他领域的Cronbach’sα系数均> 0.700。量表所有领域的重测相关系数均> 0.800。经探索性因子分析共提取6个主成分,累计方差贡献率为59.79%。量表所有条目与本领域的相关系数均大于与其他领域的相关系数。结论:中文版THYCA-QoL量表具有较好的信度和效度,可作为中国甲状腺癌患者生命质量的测评工具。展开更多
目的评价舌三针埋线疗法联合高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗脑卒中后吞咽障碍的疗效及安全性。方法将成都市第二人民医院康复科2019年1月至2020年2月住院治疗的60例脑卒中后吞咽障碍患者...目的评价舌三针埋线疗法联合高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗脑卒中后吞咽障碍的疗效及安全性。方法将成都市第二人民医院康复科2019年1月至2020年2月住院治疗的60例脑卒中后吞咽障碍患者随机分为常规治疗组、rTMS治疗组、联合治疗组,每组20例。3组患者均予内科基础治疗,常规治疗组采用吞咽直接训练和间接训练,rTMS组除采用常规治疗组方案加rTMS治疗方案,联合治疗组采用rTMS组治疗方案外加舌三针埋线疗法治疗。治疗前后采用洼田饮水试验(water swallowing test,WST)量表、标准吞咽功能评价(standardized swallowing assessment,SSA)量表、吞咽障碍特异性生活质量(swallowing quality of life questionnaire,SWAL-QOL)量表评价患者吞咽功能,采用洼田吞咽能力评定量表评价疗效,并观察不良反应。结果联合治疗组总有效率为94.7%,rTMS治疗组为88.9%,常规治疗组为68.4%,两两比较差异均有统计学意义(P<0.05)。治疗后,3组患者WST评分、SSA评分、SWAL-QOL评分均较治疗前有显著改善(P<0.05);且联合治疗组、rTMS治疗组均优于常规治疗组(P<0.05),联合治疗组优于rTMS治疗组(P<0.05)。3组均未出现严重不良反应。结论舌三针埋线疗法联合rTMS疗法能更好地改善患者脑卒中后的吞咽功能,减少误吸,提升患者生活质量和精神状态,值得临床推广。展开更多
随着医学生物学模式向生物-心理-社会医学模式的转变,生活质量（quality of life,QOL）这一指标越来越多地得到人们的关注。在评价医学结局时,中、西医使用的评价方法会有较大差别,而生活质量评价可能是中、西医之间达到疗效评定统一的...随着医学生物学模式向生物-心理-社会医学模式的转变,生活质量（quality of life,QOL）这一指标越来越多地得到人们的关注。在评价医学结局时,中、西医使用的评价方法会有较大差别,而生活质量评价可能是中、西医之间达到疗效评定统一的较好方法。展开更多
背景人工角膜植入手术是终末期角膜盲患者复明的有效手段,术后患者的视觉相关生活质量评估已然成为眼科学者研究的课题。目的比较国家眼科研究所视功能问卷(National Eye Institute Visual Functioning Questionnaire-25,NEI-VFQ-25)、...背景人工角膜植入手术是终末期角膜盲患者复明的有效手段,术后患者的视觉相关生活质量评估已然成为眼科学者研究的课题。目的比较国家眼科研究所视功能问卷(National Eye Institute Visual Functioning Questionnaire-25,NEI-VFQ-25)、视功能损害眼病患者生存质量量表(Scale of Quality of Life for Diseases with Visual Impairment,SQOL-DVI)、视功能和生活质量(visual function and quality of life,VF-QOL)量表评估人工角膜患者生活质量的效果。方法选择2015年1月-2019年12月于我中心眼科行米赫型人工角膜植入手术患者,采用NEI-VFQ-25、SQOL-DVI、VF-QOL三种量表对患者进行问卷调查,评估术后患者生活质量,并比较不同视力水平患者[以视力(visual acuity,VA)=0.3为切点]的生活质量差异。结果共纳入手术后患者48例,其中男43例(89.58%),女5例(10.42%),年龄21~81(47.08±13.08)岁。NEI-VFQ-25量表总分为50.81±20.86,VF-QOL量表总分为68.37±20.02,SQOL-DVI量表总分为101.38±36.65,VF-QOL量表总分均值占满分的百分比高于NEI-VFQ-25量表和SQOL-DVI量表(68.37%vs 50.81%和50.69%),但均显示米赫型人工角膜植入术后脱盲患者生活质量处于中等水平。不同视力水平患者比较:VA<0.3者各量表得分[Md(IQR)]均低于VA≥0.3者,差异有统计学意义[NEI-VFQ-25:40.00(28.00~50.25)vs 60.50(39.75~76.25),P=0.011;VF-QOL:68.48(56.45~84.64)vs 80.52(63.46~86.53),P=0.020;SQOL-DVI:53.75(38.50~67.00)vs 99.00(70.25~128.75),P<0.001]。各维度评估中,NEI-VFQ-25量表结果显示低视力者(VA<0.3)的整体视力、近距离活动、远距离活动、社会功能、角色限制、驾驶功能等得分更低(P<0.05),在评估视力状况对患者心理健康方面的影响时缺乏敏感性(P>0.05);VF-QOL量表结果显示低视力者的主观视觉、周边视野、活动能力等得分更低(P<0.05),在评估视力状况对患者社会功能、心理精神方面的影响时缺乏敏感性(P>0.05);SQOL-DVI量表结果显示低视力者�展开更多
文摘Background: Melasma has been shown to have a significant emotional and psychologic effect on affected patients. Although this pigmentary disorder is thought to be more prevalent among Latinos, the effect of melasma on quality of life (QOL) in this population is unknown. Objectives: The goals of this study were to translate and culturally adapt the previously validated Melasma QOL (MELASQOL) scale into Spanish language, to confirm the new scale’s reliability and validity,and to administer the scale to characterize melasma’ s effect on the health-related QOL of Spanish language-speaking Latino patients. Methods:Cross-cultural adaptation of the original questionnaire was performed using previously established guidelines. After pretesting the questionnaire in a group of 30 patients, it was tested in a group of 112 patients recruited from a community outpatient clinic. A Spanish-language health-related QOL assessment battery was also administered for validation purposes.The degree of melasma was determined on clinical examination by the investigator using the Melasma Area and Severity Index.Results: Cross-cultural adaptation of the questionnaire was successful in producing a working and understandable Spanish language version of the MELASQOL. The Spanish-language MELASQOL scale was internally reliable and demonstrated construct and content validity. The Spanish-language MELASQOL scores of patients with little to no formal education were significantly higher than those with at least a seventh-grade education.Scores were proportional to the length of time a patient had lived with melasma and were higher in patients who had previously sought treatment. Spanish-language MELASQOL score and Melasma Area and Severity Index were shown to be moderately correlated, but no differences were seen according to patient age, marital status, employment, or coexisting medical or psychiatric conditions. Limitations: Limitations area lack of data regarding socioeconomic status and limitation to Mexican and Central American female pat
文摘Objectives. This study examines quality of life (QOL) among school-aged children with perinatally acquired HIV infection and compares QOL outcomes between treatment groups that differ according to the use of protease inhibitor (PI) combination therapy (PI therapy). To gain insights into how PI therapy might influence QOL, associations between severity of illness and QOL were also investigated. Methods. Cross-sectional data for 940 children, 5 to 18 years of age, who were enrolled in Pediatric AIDS Clinical Trials Group Late Outcomes Protocol 219 were used to examine domains of caregiver-reported QOL, as assessed with the General Health Assessment for Children, during 1999. The General Health Assessment for Children is an age-specific, modular, QOL assessment that was developed for the study with previously validated measures. QOL differences between treatment groups were estimated with linear and logistic regressions that controlled for sociodemographic characteristics (age, gender, raceethnicity, maternalcaregiver education, and respondent) and severity-of-illness indicators related to receipt of PI therapy (AIDS status, log10 CD4+cell counts, and height-for-age z scores). Results. The mean age of participants was 9.7 years. Most children were non-Hispanic black (54%) or Hispanic (31%), and 49%of the participants were female. At the 1999 study visit, ～14%of children had severe immune suppression ( < 15%CD4+cells), whereas 62%of children had ≥25%CD4+cells, ie, no immune suppression. Participants did exhibit some lag in growth, with mean height and weight z scores of-0.70 and-0.20, respectively. Twentyeight percent of the children were reported to have met criteria for AIDS at study entry (1993-1999). When treatment groups were compared, children receiving PI therapy (72%) were older, had lower CD4 +cell percentages, and had lower height and weight z scores than did those receiving non-PI therapies. They were also more likely to have met criteria for AIDS at study entry. The most commonly used PIs were ritonav
文摘目的:测定评价Mapi Research Trust授权的便秘患者生存质量自评量表PAC-QOL中文版的信度、效度和反应度.方法:通过测定283例罗马Ⅲ标准诊断的功能性便秘患者的生存质量对PAC-QOL中文版进行评价.结果:通过探索性因子分析,量表可分为生理、社会心理、担忧和满意度4个公因子,与原版量表基本一致;各条目与其所属领域的相关性有显著统计学意义(P<0.01);各领域及总分的内在信度Cronbachα系数除生理维度为0.69外,其余均在0.70以上;治疗1mo后与治疗前相比,各维度得分和总分有显著统计学差异(P<0.01);便秘患者治疗前与健康人群相比,各维度得分和总分有显著统计学差异(P<0.01).结论:PAC-QOL中文版具有较好的信度、效度和反应度,可用于中国便秘患者生存质量的测定.
文摘目的:汉化甲状腺癌特异性生命质量(yroid Cancer-specic Quality of Life,THYCA-QoL)量表,并对其进行信度和效度检验。方法:征得荷兰蒂尔堡大学HUSSON教授同意并获得量表授权,对英文版THYCA-QoL量表进行翻译、回译及文化调试,形成中文版THYCAQoL量表。采用中文版欧洲癌症研究与治疗组织生命质量核心量表C30(European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30,EORTC QLQ-C30)和THYCA-QoL量表对成都市3所三甲医院(四川省肿瘤医院、四川省人民医院和中国人民解放军西部战区总医院)336例甲状腺癌患者进行调查。其中106例患者于第一次测评后2～3 d,再次予以重测。采用Cronbach’sα系数评价量表的内部一致信度,采用重测相关系数r评价量表的重测信度。采用探索性因子分析评价量表的结构效度,采用条目-领域相关性分析评价量表的集合效度与区分效度。结果:中文版THYCA-QoL量表除神经肌肉领域(Cronbach’sα系数为0.671)和感官领域(Cronbach’sα系数为0.530)外,其他领域的Cronbach’sα系数均> 0.700。量表所有领域的重测相关系数均> 0.800。经探索性因子分析共提取6个主成分,累计方差贡献率为59.79%。量表所有条目与本领域的相关系数均大于与其他领域的相关系数。结论:中文版THYCA-QoL量表具有较好的信度和效度,可作为中国甲状腺癌患者生命质量的测评工具。
文摘目的评价舌三针埋线疗法联合高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗脑卒中后吞咽障碍的疗效及安全性。方法将成都市第二人民医院康复科2019年1月至2020年2月住院治疗的60例脑卒中后吞咽障碍患者随机分为常规治疗组、rTMS治疗组、联合治疗组,每组20例。3组患者均予内科基础治疗,常规治疗组采用吞咽直接训练和间接训练,rTMS组除采用常规治疗组方案加rTMS治疗方案,联合治疗组采用rTMS组治疗方案外加舌三针埋线疗法治疗。治疗前后采用洼田饮水试验(water swallowing test,WST)量表、标准吞咽功能评价(standardized swallowing assessment,SSA)量表、吞咽障碍特异性生活质量(swallowing quality of life questionnaire,SWAL-QOL)量表评价患者吞咽功能,采用洼田吞咽能力评定量表评价疗效,并观察不良反应。结果联合治疗组总有效率为94.7%,rTMS治疗组为88.9%,常规治疗组为68.4%,两两比较差异均有统计学意义(P<0.05)。治疗后,3组患者WST评分、SSA评分、SWAL-QOL评分均较治疗前有显著改善(P<0.05);且联合治疗组、rTMS治疗组均优于常规治疗组(P<0.05),联合治疗组优于rTMS治疗组(P<0.05)。3组均未出现严重不良反应。结论舌三针埋线疗法联合rTMS疗法能更好地改善患者脑卒中后的吞咽功能,减少误吸,提升患者生活质量和精神状态,值得临床推广。
文摘背景人工角膜植入手术是终末期角膜盲患者复明的有效手段,术后患者的视觉相关生活质量评估已然成为眼科学者研究的课题。目的比较国家眼科研究所视功能问卷(National Eye Institute Visual Functioning Questionnaire-25,NEI-VFQ-25)、视功能损害眼病患者生存质量量表(Scale of Quality of Life for Diseases with Visual Impairment,SQOL-DVI)、视功能和生活质量(visual function and quality of life,VF-QOL)量表评估人工角膜患者生活质量的效果。方法选择2015年1月-2019年12月于我中心眼科行米赫型人工角膜植入手术患者,采用NEI-VFQ-25、SQOL-DVI、VF-QOL三种量表对患者进行问卷调查,评估术后患者生活质量,并比较不同视力水平患者[以视力(visual acuity,VA)=0.3为切点]的生活质量差异。结果共纳入手术后患者48例,其中男43例(89.58%),女5例(10.42%),年龄21~81(47.08±13.08)岁。NEI-VFQ-25量表总分为50.81±20.86,VF-QOL量表总分为68.37±20.02,SQOL-DVI量表总分为101.38±36.65,VF-QOL量表总分均值占满分的百分比高于NEI-VFQ-25量表和SQOL-DVI量表(68.37%vs 50.81%和50.69%),但均显示米赫型人工角膜植入术后脱盲患者生活质量处于中等水平。不同视力水平患者比较:VA<0.3者各量表得分[Md(IQR)]均低于VA≥0.3者,差异有统计学意义[NEI-VFQ-25:40.00(28.00~50.25)vs 60.50(39.75~76.25),P=0.011;VF-QOL:68.48(56.45~84.64)vs 80.52(63.46~86.53),P=0.020;SQOL-DVI:53.75(38.50~67.00)vs 99.00(70.25~128.75),P<0.001]。各维度评估中,NEI-VFQ-25量表结果显示低视力者(VA<0.3)的整体视力、近距离活动、远距离活动、社会功能、角色限制、驾驶功能等得分更低(P<0.05),在评估视力状况对患者心理健康方面的影响时缺乏敏感性(P>0.05);VF-QOL量表结果显示低视力者的主观视觉、周边视野、活动能力等得分更低(P<0.05),在评估视力状况对患者社会功能、心理精神方面的影响时缺乏敏感性(P>0.05);SQOL-DVI量表结果显示低视力者�
