Kidney disease is a worldwide public health problem.The prevalence of end-stage renal disease （ESRD）, a final outcome of kidney disease, has increased progressively in the past decades and has emerged as a great bur...Kidney disease is a worldwide public health problem.The prevalence of end-stage renal disease （ESRD）, a final outcome of kidney disease, has increased progressively in the past decades and has emerged as a great burden to the healthcare system in China. Glomerulonephritis is still the most common cause of ESRD in China. However, the prevalence of diabetes and hypertension are increasing dramatically. There are modifiable risk factors for the development of progressive renal dysfunction. The challenge is to identify the disease and deliver effective therapies at the right time with the right tools. In the last two years,展开更多
Electrogenerated chemiluminescence, also known as electrochemiluminescence, abbreviated ECL, is a new technology combining electrochemistry and chemiluminescence. It is generated by high-energy electrons generated on ...Electrogenerated chemiluminescence, also known as electrochemiluminescence, abbreviated ECL, is a new technology combining electrochemistry and chemiluminescence. It is generated by high-energy electrons generated on the surface of the electrode in the emission process of excited state photons formed in the transfer process, and is a perfect combination of electrochemistry and spectroscopy. It not only has the advantages of good environment, high luminosity and wide dynamic range, but also has the characteristics of simple, stable and practical electrochemical methods, and nearly zero background signals. With the rapid development of nanomaterials, due to their unique electrical properties, large specific surface area, good biocompatibility and other characteristics, various nanomaterials have been widely used in the field of biosensors and sensitive detection. This review presented a general description of the research status of four different types of biosensors from the last decade years, summarized the application forms of nanomaterials in ECL biosensor, and outlines the building patterns and application example of the four main types of biosensors.展开更多
Objective：The aim of this study was to help people comprehensively understand the research advances related to ring finger protein 213 （RNF213） in moyamoya disease （MMD） and to understand the disease at the molec...Objective：The aim of this study was to help people comprehensively understand the research advances related to ring finger protein 213 （RNF213） in moyamoya disease （MMD） and to understand the disease at the molecular level to provide a new perspective of the diagnosis of the disease.Data Sources：This review was based on data in articles published between 2005 and 2015 that were retrieved from the PubMed database.The search terms included RNF213,MMD,intracranial major artery stenosis/occlusion （ICASO）,genotype,phenotype,mutant and variants,and the combinations of these terms.Study Selection：Articles related to MMD and RNF213 were selected for review,and we also reviewed publications related to ICASO.Results：RNF213 is not only associated with MMD but also associated with intracranial major artery stenosis.In addition,RNF213 variants exhibit apparent ethnic diversity;specifically,the c.14576G〉A variant is mainly detected in Korean,Chinese,and Japanese populations,particularly the latter population.The genotypes of RNF213 correlate with the phenotypes of MMD;for example,the homozygous c.14576G〉A variant is associated with early-onset,severe symptoms,and an unfavorable prognosis.Furthermore,the RNF213 c.14576G〉A variant should be considered during the diagnosis of MMD because no patients with quasi-MMD have been reported to carry the RNF213 c.14576G〉A variant whereas 66 of 78 patients with definite MMD have been found to carry this variant.Conclusions：The growing literature demonstrates that MMD is primarily caused by the synergy of genetic and environmental factors,and unknown genetic modifiers might play roles in the etiology of MMD.Further research should be conducted to clarify the pathogenic mechanism of MMD.展开更多
文摘Kidney disease is a worldwide public health problem.The prevalence of end-stage renal disease （ESRD）, a final outcome of kidney disease, has increased progressively in the past decades and has emerged as a great burden to the healthcare system in China. Glomerulonephritis is still the most common cause of ESRD in China. However, the prevalence of diabetes and hypertension are increasing dramatically. There are modifiable risk factors for the development of progressive renal dysfunction. The challenge is to identify the disease and deliver effective therapies at the right time with the right tools. In the last two years,
基金supported by the National Natural Science Foundation of China (Nos. 21675178, 21575167 and 21775167)the Guangdong Provincial Natural Science Foundation of China (No. 2016A030313358)+1 种基金the Research and Development Plan for Key Areas of Food Safety in Guangdong Province of China (No. 2019B020211001)the Guangzhou Science and Technology Program of China (No. 201604020165)
文摘Electrogenerated chemiluminescence, also known as electrochemiluminescence, abbreviated ECL, is a new technology combining electrochemistry and chemiluminescence. It is generated by high-energy electrons generated on the surface of the electrode in the emission process of excited state photons formed in the transfer process, and is a perfect combination of electrochemistry and spectroscopy. It not only has the advantages of good environment, high luminosity and wide dynamic range, but also has the characteristics of simple, stable and practical electrochemical methods, and nearly zero background signals. With the rapid development of nanomaterials, due to their unique electrical properties, large specific surface area, good biocompatibility and other characteristics, various nanomaterials have been widely used in the field of biosensors and sensitive detection. This review presented a general description of the research status of four different types of biosensors from the last decade years, summarized the application forms of nanomaterials in ECL biosensor, and outlines the building patterns and application example of the four main types of biosensors.
基金This study was supported by the grants from the National Science and Technology Supporting Plan （the ＂11^th Five-Year Plan＂） （No. 2006BAI01A13） and the National Natural Science Foundation of China （No. 81371292）.
文摘Objective：The aim of this study was to help people comprehensively understand the research advances related to ring finger protein 213 （RNF213） in moyamoya disease （MMD） and to understand the disease at the molecular level to provide a new perspective of the diagnosis of the disease.Data Sources：This review was based on data in articles published between 2005 and 2015 that were retrieved from the PubMed database.The search terms included RNF213,MMD,intracranial major artery stenosis/occlusion （ICASO）,genotype,phenotype,mutant and variants,and the combinations of these terms.Study Selection：Articles related to MMD and RNF213 were selected for review,and we also reviewed publications related to ICASO.Results：RNF213 is not only associated with MMD but also associated with intracranial major artery stenosis.In addition,RNF213 variants exhibit apparent ethnic diversity;specifically,the c.14576G〉A variant is mainly detected in Korean,Chinese,and Japanese populations,particularly the latter population.The genotypes of RNF213 correlate with the phenotypes of MMD;for example,the homozygous c.14576G〉A variant is associated with early-onset,severe symptoms,and an unfavorable prognosis.Furthermore,the RNF213 c.14576G〉A variant should be considered during the diagnosis of MMD because no patients with quasi-MMD have been reported to carry the RNF213 c.14576G〉A variant whereas 66 of 78 patients with definite MMD have been found to carry this variant.Conclusions：The growing literature demonstrates that MMD is primarily caused by the synergy of genetic and environmental factors,and unknown genetic modifiers might play roles in the etiology of MMD.Further research should be conducted to clarify the pathogenic mechanism of MMD.
