Surgery remains the primary determinant of cure in patients with localized rectal cancer, and total mesorectal excision is now widely accepted as standard of care. The widespread implementation of neoadjuvant shortcou...Surgery remains the primary determinant of cure in patients with localized rectal cancer, and total mesorectal excision is now widely accepted as standard of care. The widespread implementation of neoadjuvant shortcourse radiotherapy (RT) or long-course chemoradiotherapy (CRT) has reduced local recurrence rates from 25% to 40% to less than 10%; Preoperative RT in resectable rectal cancer has a number of potential advantages, most importantly reducing local recurrence, and down-staging effect. In this article making a comprehensive literature review searching the reliable medical data bases of PubMed and Cochrane we present all available information on the role of radiation therapy alone or in combination with chemotherapy in preoperative setting of rectal cancer. Data reported show that in locally advanced rectal cancer the addition of radiation therapy or CRT pre surgically has significantly improved sphincter prevention surgery. Moreover, the addition of chemotherapy to radiation therapy in preoperative setting has significantly improved pathologic complete response rate and loco-regional control rate without improvement in sphincter preserving surgery. Finally, the results of recently published randomized trials have shown a significant improvement of prevs postoperative CRT on local control; however, there was no effect on overall survival.展开更多
Gastric and esophageal adenocarcinomas are one of the main causes of cancer-related death worldwide. While the incidence of gastric adenocarcinoma is decreasing, the incidence of gastroesophageal junction adenocarcino...Gastric and esophageal adenocarcinomas are one of the main causes of cancer-related death worldwide. While the incidence of gastric adenocarcinoma is decreasing, the incidence of gastroesophageal junction adenocarcinoma is rising rapidly in Western countries. Considering that surgical resection is currently the major curative treatment, and that the 5-year survival rate highly depends on the p TNM stage at diagnosis, gastroesophageal adenocarcinoma management is very challenging for oncologists. Several treatment strategies are being evaluated, and among them systemic chemotherapy, to decrease recurrences and improve overall survival. The MAGIC and FNCLCCFFCD trials showed a survival benefit of perioperative chemotherapy in patients with operable gastric and lower esophageal cancer, and these results had an impact on the European clinical practice. New strategies, including induction chemotherapy followed by preoperative chemoradiotherapy, targeted therapies in combination with perioperative chemotherapy and the new cytotoxic regimens, are currently assessed to improve current standards and help developing patienttailored therapeutic interventions.展开更多
2008～2010年，在广西涠洲岛进行了大珠母贝（Pinctada maxima Jameson）游离珍珠培育实验。实验过程中采用解剖法优选植核核位、几种术前处理方法和低温处理小片贝制备外套膜小片等技术，旨在提高育珠贝留核率、成珠率和优珠率。结果...2008～2010年，在广西涠洲岛进行了大珠母贝（Pinctada maxima Jameson）游离珍珠培育实验。实验过程中采用解剖法优选植核核位、几种术前处理方法和低温处理小片贝制备外套膜小片等技术，旨在提高育珠贝留核率、成珠率和优珠率。结果表明，在大珠母贝内脏囊缩足肌左右两侧各有一个适合培育游离珍珠的核位，分别称为左袋和右袋，实际操作中只有左袋可以植入珠核培育游离珍珠；不同术前处理实验组的植核贝休养期成活率差异不显著（P〉0．05），但留核率、成珠率显著差异（P〈0．05），其中采用传统术前处理和低温处理相结合的综合术前处理方法可有效提高留核率、成珠率平均达78．2％和80．1％；低温处理小片贝与传统方法制备的大珠母贝外套膜小片的育珠效果（成珠率、优珠率、正圆珠比例）存在显著差异（P〈0．05），且在实验温度范围内，成珠率、优珠率、正圆珠比例随处理温度的降低而增高，在4～8℃达到最好育珠效果，成珠率、优珠率和正圆珠比例分别达到98％、53％和30％左右；在术后休养期，植核贝吐核高峰出现植核后5-t5d，手术伤口愈合时间为15-20d，育殊贝的死亡高峰出现在术后的第20～30天。在水温25～30℃条件下，珠核表面形成珍珠层的时间为45d左右。展开更多
Despite the fact that gastric cancer is decreasing in incidence in the United States,it remains one of the most commonly diagnosed and most fatal cancers worldwide.In localised disease,surgery remains the cornerstone ...Despite the fact that gastric cancer is decreasing in incidence in the United States,it remains one of the most commonly diagnosed and most fatal cancers worldwide.In localised disease,surgery remains the cornerstone of treatment.Nevertheless,the low overall survival rates at 5 years due to locoregional and distant recurrences has led to a large debate regarding the role of radiation therapy and chemotherapy in addition to curative resection.Recent data have shown that,even with improved surgical techniques,locoregional failure rates in these patients ranged between 57% and 88%.Failures were noted in the gastric bed,regional nodes,gastric remnant,anastomosis and duodenal stump,all of which can be encompassed in a regional radiation f ield,indicating the need of further locoregional treatment.In this article,a comprehensive literature review of the reliable medical databases of PubMed and Cochrane is made and we present all available information on the role of radiation therapy in the preoperative and postoperative setting of gastric cancer.Data reported show that in locally advanced gastric cancer the addition of radiation therapy post surgery has signif icantly improved diseasefree survival as well as overall survival.Moreover,in unresectable gastric cancer,the combination of radiation therapy with chemotherapy has significantly improvedmean and overall survival rates.The role of radiation therapy in patients with resectable gastric cancer is being further evaluated in ongoing phase Ⅲ trials.展开更多
文摘Surgery remains the primary determinant of cure in patients with localized rectal cancer, and total mesorectal excision is now widely accepted as standard of care. The widespread implementation of neoadjuvant shortcourse radiotherapy (RT) or long-course chemoradiotherapy (CRT) has reduced local recurrence rates from 25% to 40% to less than 10%; Preoperative RT in resectable rectal cancer has a number of potential advantages, most importantly reducing local recurrence, and down-staging effect. In this article making a comprehensive literature review searching the reliable medical data bases of PubMed and Cochrane we present all available information on the role of radiation therapy alone or in combination with chemotherapy in preoperative setting of rectal cancer. Data reported show that in locally advanced rectal cancer the addition of radiation therapy or CRT pre surgically has significantly improved sphincter prevention surgery. Moreover, the addition of chemotherapy to radiation therapy in preoperative setting has significantly improved pathologic complete response rate and loco-regional control rate without improvement in sphincter preserving surgery. Finally, the results of recently published randomized trials have shown a significant improvement of prevs postoperative CRT on local control; however, there was no effect on overall survival.
文摘Gastric and esophageal adenocarcinomas are one of the main causes of cancer-related death worldwide. While the incidence of gastric adenocarcinoma is decreasing, the incidence of gastroesophageal junction adenocarcinoma is rising rapidly in Western countries. Considering that surgical resection is currently the major curative treatment, and that the 5-year survival rate highly depends on the p TNM stage at diagnosis, gastroesophageal adenocarcinoma management is very challenging for oncologists. Several treatment strategies are being evaluated, and among them systemic chemotherapy, to decrease recurrences and improve overall survival. The MAGIC and FNCLCCFFCD trials showed a survival benefit of perioperative chemotherapy in patients with operable gastric and lower esophageal cancer, and these results had an impact on the European clinical practice. New strategies, including induction chemotherapy followed by preoperative chemoradiotherapy, targeted therapies in combination with perioperative chemotherapy and the new cytotoxic regimens, are currently assessed to improve current standards and help developing patienttailored therapeutic interventions.
文摘2008～2010年，在广西涠洲岛进行了大珠母贝（Pinctada maxima Jameson）游离珍珠培育实验。实验过程中采用解剖法优选植核核位、几种术前处理方法和低温处理小片贝制备外套膜小片等技术，旨在提高育珠贝留核率、成珠率和优珠率。结果表明，在大珠母贝内脏囊缩足肌左右两侧各有一个适合培育游离珍珠的核位，分别称为左袋和右袋，实际操作中只有左袋可以植入珠核培育游离珍珠；不同术前处理实验组的植核贝休养期成活率差异不显著（P〉0．05），但留核率、成珠率显著差异（P〈0．05），其中采用传统术前处理和低温处理相结合的综合术前处理方法可有效提高留核率、成珠率平均达78．2％和80．1％；低温处理小片贝与传统方法制备的大珠母贝外套膜小片的育珠效果（成珠率、优珠率、正圆珠比例）存在显著差异（P〈0．05），且在实验温度范围内，成珠率、优珠率、正圆珠比例随处理温度的降低而增高，在4～8℃达到最好育珠效果，成珠率、优珠率和正圆珠比例分别达到98％、53％和30％左右；在术后休养期，植核贝吐核高峰出现植核后5-t5d，手术伤口愈合时间为15-20d，育殊贝的死亡高峰出现在术后的第20～30天。在水温25～30℃条件下，珠核表面形成珍珠层的时间为45d左右。
文摘Despite the fact that gastric cancer is decreasing in incidence in the United States,it remains one of the most commonly diagnosed and most fatal cancers worldwide.In localised disease,surgery remains the cornerstone of treatment.Nevertheless,the low overall survival rates at 5 years due to locoregional and distant recurrences has led to a large debate regarding the role of radiation therapy and chemotherapy in addition to curative resection.Recent data have shown that,even with improved surgical techniques,locoregional failure rates in these patients ranged between 57% and 88%.Failures were noted in the gastric bed,regional nodes,gastric remnant,anastomosis and duodenal stump,all of which can be encompassed in a regional radiation f ield,indicating the need of further locoregional treatment.In this article,a comprehensive literature review of the reliable medical databases of PubMed and Cochrane is made and we present all available information on the role of radiation therapy in the preoperative and postoperative setting of gastric cancer.Data reported show that in locally advanced gastric cancer the addition of radiation therapy post surgery has signif icantly improved diseasefree survival as well as overall survival.Moreover,in unresectable gastric cancer,the combination of radiation therapy with chemotherapy has significantly improvedmean and overall survival rates.The role of radiation therapy in patients with resectable gastric cancer is being further evaluated in ongoing phase Ⅲ trials.
