2008年初《Clinical and Experimenta Allergy》发表了由英国国立皇家耳鼻咽喉科医院Scadding等9位学者共同完成的"英国变态反应和临床免疫学会鼻鼻窦炎和鼻息肉诊疗指南"。该指南在收集分析相关文献的基础上,参考医学专家的...2008年初《Clinical and Experimenta Allergy》发表了由英国国立皇家耳鼻咽喉科医院Scadding等9位学者共同完成的"英国变态反应和临床免疫学会鼻鼻窦炎和鼻息肉诊疗指南"。该指南在收集分析相关文献的基础上,参考医学专家的意见,对数据类型和推荐等级分别进行分类和分级,反映了所依赖的数据可靠程度。英国指南短小精悍,省略了基础研究的数据,重点突出临床实用性,主要针对从事变态反应工作的内科医师。展开更多
From the perspective of cultivation of engineering-type software talents,we combine with the CDIO engineering education pattern reformation of American Massachusetts Institute of Technology,adopt four step engineering...From the perspective of cultivation of engineering-type software talents,we combine with the CDIO engineering education pattern reformation of American Massachusetts Institute of Technology,adopt four step engineering content including Conceive,Design,Implement and Operate as the cultivating goal of students' ability,and analyze the current talent cultivation pattern,summarize the intensive talent cultivation of Software College,Shandong University in recent years,and bring forward an innovation on talent cultivation pattern,and illustrate practicing process under the new pattern,and report the results and achievements of talents cultivation.展开更多
BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediat...BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD patients.Among commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical practice.AIM To investigate the frequency of anti-islet autoantibodies in AITD patients.METHODS Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these groups.RESULTS The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two groups.Notably,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,respectively.Furthermore,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for GADA.Additionally,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual autoantibodies.Among the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D compared to those without diabetes(37.5%vs 5.0%,P<0展开更多
文摘2008年初《Clinical and Experimenta Allergy》发表了由英国国立皇家耳鼻咽喉科医院Scadding等9位学者共同完成的"英国变态反应和临床免疫学会鼻鼻窦炎和鼻息肉诊疗指南"。该指南在收集分析相关文献的基础上,参考医学专家的意见,对数据类型和推荐等级分别进行分类和分级,反映了所依赖的数据可靠程度。英国指南短小精悍,省略了基础研究的数据,重点突出临床实用性,主要针对从事变态反应工作的内科医师。
文摘From the perspective of cultivation of engineering-type software talents,we combine with the CDIO engineering education pattern reformation of American Massachusetts Institute of Technology,adopt four step engineering content including Conceive,Design,Implement and Operate as the cultivating goal of students' ability,and analyze the current talent cultivation pattern,summarize the intensive talent cultivation of Software College,Shandong University in recent years,and bring forward an innovation on talent cultivation pattern,and illustrate practicing process under the new pattern,and report the results and achievements of talents cultivation.
文摘BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD patients.Among commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical practice.AIM To investigate the frequency of anti-islet autoantibodies in AITD patients.METHODS Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these groups.RESULTS The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two groups.Notably,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,respectively.Furthermore,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for GADA.Additionally,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual autoantibodies.Among the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D compared to those without diabetes(37.5%vs 5.0%,P<0
