The aim of this article is to review the outcomes of platelet preparations in dentistry. A structured electronic search discovered 348 articles, which described the use of autologous platelet concentrates with a relev...The aim of this article is to review the outcomes of platelet preparations in dentistry. A structured electronic search discovered 348 articles, which described the use of autologous platelet concentrates with a relevance to clinical dentistry. Among these articles, 220 articles investigated platelet rich plasma, 99 investigated platelet rich fibrin, 22 investigated plasma rich in growth factors and 7 investigated the use of concentrated growth factors. Several studies reported beneficial treament outcomes in terms of enhanced bone and soft tissue regeneration.展开更多
背景:牙列缺损患者缺牙区的软硬组织不足是影响口腔种植治疗效果的重要因素,在拔牙后或种植体植入期间使用血小板浓缩物进行辅助治疗有望解决这一难题,改善口腔种植疗效。目的:本研究旨在通过检索近10年发表的有关血小板浓缩物在种植领...背景:牙列缺损患者缺牙区的软硬组织不足是影响口腔种植治疗效果的重要因素,在拔牙后或种植体植入期间使用血小板浓缩物进行辅助治疗有望解决这一难题,改善口腔种植疗效。目的:本研究旨在通过检索近10年发表的有关血小板浓缩物在种植领域应用的文献,总结目前文献研究中的详细情况及研究热点,进而探索该领域研究的流行趋势,为该领域未来研究及发展方向提供指引和参考。方法:在Web of Science数据库核心合集中检索在2012-2021年间发表的有关血小板浓缩物在口腔种植领域应用的文献,将检出文献进行去重及筛选后,使用Citespace 5.8 R3软件对筛选后的文献进行关键词与文献共被引等情况的分析,并将分析结果进行可视化展示。结果与结论:本研究共纳入有效文献328篇。2012-2021年间,血小板浓缩物在口腔种植领域应用的文献数量在前期呈略微上升,而在后期趋于平稳。在本研究纳入的文献中,通过对关键词的使用频次分析、关键词的聚类分析以及高被引文献的分析可知,在2012-2021年间,该领域的研究中血小板浓缩物与“自体骨”的临床疗效受到了学界的较多关注;同时,血小板浓缩物中富含的多种“生长因子”的相关文章也逐年增加。在口腔种植相关研究中,组织工程常用种子细胞“间充质干细胞”、临床种植骨量不足的常用材料“膜”及常用增骨术式“上颌窦提升术”均与血小板浓缩物存在一定的研究热度。展开更多
AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet con...AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. METHODS: A retrospective case series of 8 eyes of 8 patients was described. RESULTS: In all cases investigated, the plateletassisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure;the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea;a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial(RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer(ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole closure.CONCLUSION: The data show that there are different modes of foveal regeneration after closure of macular holes with(re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells.展开更多
文摘The aim of this article is to review the outcomes of platelet preparations in dentistry. A structured electronic search discovered 348 articles, which described the use of autologous platelet concentrates with a relevance to clinical dentistry. Among these articles, 220 articles investigated platelet rich plasma, 99 investigated platelet rich fibrin, 22 investigated plasma rich in growth factors and 7 investigated the use of concentrated growth factors. Several studies reported beneficial treament outcomes in terms of enhanced bone and soft tissue regeneration.
文摘背景:牙列缺损患者缺牙区的软硬组织不足是影响口腔种植治疗效果的重要因素,在拔牙后或种植体植入期间使用血小板浓缩物进行辅助治疗有望解决这一难题,改善口腔种植疗效。目的:本研究旨在通过检索近10年发表的有关血小板浓缩物在种植领域应用的文献,总结目前文献研究中的详细情况及研究热点,进而探索该领域研究的流行趋势,为该领域未来研究及发展方向提供指引和参考。方法:在Web of Science数据库核心合集中检索在2012-2021年间发表的有关血小板浓缩物在口腔种植领域应用的文献,将检出文献进行去重及筛选后,使用Citespace 5.8 R3软件对筛选后的文献进行关键词与文献共被引等情况的分析,并将分析结果进行可视化展示。结果与结论:本研究共纳入有效文献328篇。2012-2021年间,血小板浓缩物在口腔种植领域应用的文献数量在前期呈略微上升,而在后期趋于平稳。在本研究纳入的文献中,通过对关键词的使用频次分析、关键词的聚类分析以及高被引文献的分析可知,在2012-2021年间,该领域的研究中血小板浓缩物与“自体骨”的临床疗效受到了学界的较多关注;同时,血小板浓缩物中富含的多种“生长因子”的相关文章也逐年增加。在口腔种植相关研究中,组织工程常用种子细胞“间充质干细胞”、临床种植骨量不足的常用材料“膜”及常用增骨术式“上颌窦提升术”均与血小板浓缩物存在一定的研究热度。
文摘AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. METHODS: A retrospective case series of 8 eyes of 8 patients was described. RESULTS: In all cases investigated, the plateletassisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure;the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea;a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial(RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer(ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole closure.CONCLUSION: The data show that there are different modes of foveal regeneration after closure of macular holes with(re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells.
