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荧光碳点的合成、性质和应用 被引量:9
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作者 王胜达 袁楠 +1 位作者 朱志峰 蒋阳 《影像科学与光化学》 CAS CSCD 北大核心 2016年第3期203-218,共16页
与传统半导体发光材料相比,荧光碳点作为一种新型的碳纳米发光材料,因其优异的生物相容性、良好的发光性能、简单的合成工艺、低廉的成本等优点而备受关注。荧光碳点在生物荧光标定、医学传感器、光诊疗剂以及发光器件等方面具有广阔的... 与传统半导体发光材料相比,荧光碳点作为一种新型的碳纳米发光材料,因其优异的生物相容性、良好的发光性能、简单的合成工艺、低廉的成本等优点而备受关注。荧光碳点在生物荧光标定、医学传感器、光诊疗剂以及发光器件等方面具有广阔的应用潜力。本文重点阐述了荧光碳点的合成方法、显微结构分析、荧光机理及应用的最新成果,希望为荧光碳点合成与应用研究的发展提供参考。 展开更多
关键词 碳点 荧光 生物成像 光诊疗剂 发光器件
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聚集诱导发光材料在光学诊疗中的研究进展 被引量:9
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作者 张志军 康苗苗 +4 位作者 王媛玮 宋光杰 温海飞 王东 唐本忠 《发光学报》 EI CAS CSCD 北大核心 2021年第3期361-378,共18页
光学诊疗是一种利用光激活的激发态能量转化效应实现疾病诊断和同时原位治疗的新型诊疗模式,它具有时空选择性高、毒副作用低、疗效好和可控性强等优点,在疾病诊疗中展现了巨大的应用潜力。近些年,得益于其生物安全性好、光物理性质可... 光学诊疗是一种利用光激活的激发态能量转化效应实现疾病诊断和同时原位治疗的新型诊疗模式,它具有时空选择性高、毒副作用低、疗效好和可控性强等优点,在疾病诊疗中展现了巨大的应用潜力。近些年,得益于其生物安全性好、光物理性质可调、易于合成和功能化修饰、出色的荧光和光敏性能、以及可便于构筑多模态诊疗试剂等优势,聚集诱导发光材料在光学诊疗领域取得了重大突破进展。基于此,本文从如何通过精准分子设计以及调控分子在聚集态下的运动构筑高效的聚集诱导发光光诊疗体系出发,从荧光成像指导的光动力治疗、光声成像指导的光热治疗和多模态成像指导的协同治疗三个方面总结了聚集诱导发光材料在光学诊疗领域的最新研究进展,并对其未来的发展方向与前景进行了展望。 展开更多
关键词 聚集诱导发光 光学诊疗 聚集增强诊疗 生物医学应用
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Applications of phototheranostic nanoagents in photodynamic therapy 被引量:8
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作者 Jayeeta Bhaumik Amit Kumar Mittal +2 位作者 Avik Banedee Yusuf Chisti Uttam Chand Banerjee 《Nano Research》 SCIE EI CAS CSCD 2015年第5期1373-1394,共22页
Nanotherapeutics has an increasing role in the treatment of diseases such as cancer. In photodynamic therapy (PDT) a therapeutically inactive photosensitizer compound is selectively activated by light to produce mol... Nanotherapeutics has an increasing role in the treatment of diseases such as cancer. In photodynamic therapy (PDT) a therapeutically inactive photosensitizer compound is selectively activated by light to produce molecules capable of killing diseased cells and pathogens. A phototheranostic agent can be defined as a single nanoentity with the capabilities for targeted delivery, optical imaging and photodynamic treatment of a disease. Malignant cells, tissue and microbial etiologic agents can be effectively targeted by PDT. Photodynamic therapy is noninvasive, or minimally invasive, and has few side effects as damage to healthy tissue is minimized and the killing effect is localized. Various forms of cancer, acne and other diseases may be treated. The in vivo efficacy of photosensitizers is further improved by attaching them to nanostructures capable of targeting the diseased site. Such photosensitizer-functionalized nanostructures, or nano- therapeutics, allow site-specific delivery of imaging and therapeutic agents for improved phototheranostic performance. This review explores the potential applications of phototheranostic nanostructures in diagnosis and therapy. 展开更多
关键词 phototheranostics photodynamic therapy PHOTOSENSITIZERS THERANOSTICS NANOMEDICINE
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Acceptor-engineering tailored type-Ⅰ photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics
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作者 Jiangao Li Niu Niu +5 位作者 Deliang Wang Xue Liu Yi Qin Lei Wang Ben Zhong Tang Dong Wang 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第8期2647-2660,共14页
Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer photot... Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline(ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared(NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole(BBTD) and 6,7-diphenylthiadiazoloquinoxaline(DPTQ), ITQ-based photosensitizer(TITQ) showed superior aggregation-induced emission(AIE) characteristics, much stronger type-I reactive oxygen species(ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy. 展开更多
关键词 phototheranostics aggregation-induced emission NIR-Ⅱfluorescence acceptor engineering photodynamic-photothermal therapy
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Construction of a 980 nm laser-activated Pt(Ⅱ)metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization 被引量:1
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作者 Yuling Xu Chonglu Li +6 位作者 Jusung An Xin Ma Jingfang Yang Lishi Luo Yun Deng Jong Seung Kim Yao Sun 《Science China Chemistry》 SCIE EI CAS CSCD 2023年第1期155-163,共9页
Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vi... Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult.We therefore synthesized a novel Pt(Ⅱ)metallacycle(Pt1110)that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue.We found that Pt1110 significantly improved photothermal conversion(95%improvement)and ^(1)O_(2) generation(ΦΔ75%increase)compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation(0.72 W/cm^(2)).In addition,Pt1110 has little to no toxicity to cells.After incorporated into liposome,Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation,which was accurately observed by NIR-Ⅱfluorescence imaging.This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue. 展开更多
关键词 supramolecular chemistry METALLACYCLE NIR-Ⅱfluorescence imaging phototheranostics deep penetration
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Gathering brings strength:How organic aggregates boost disease phototheranostics 被引量:5
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作者 Ji Qi Hanlin Ou +1 位作者 Qian Liu Dan Ding 《Aggregate》 2021年第1期95-113,共19页
Phototheranostics that concurrently and complementarily integrate real-time diagnosis and in situ therapeutic capabilities in one platform has become the advancing edge of precision medicine.Organic agents possess the... Phototheranostics that concurrently and complementarily integrate real-time diagnosis and in situ therapeutic capabilities in one platform has become the advancing edge of precision medicine.Organic agents possess the merits of facile preparation,high purity,tunable photophysical property,good biocompatibility,and potential biodegradability,which have shown great promise for disease theranostics.This review summarizes the recent achievements of organic phototheranostic agents and applications,especially which rationally utilize energy dissipation pathways of Jablonski diagram to modulate the fluorescence emission,photoacoustic/photothermal production,and photodynamic processes.Of particular interest are the systems exhibiting huge differences in aggregate state as compared with the solution or single molecule form,during which the intramolecular motions play an important role in regulating the photophysical properties.The recent advances from such an aspect for biomedical applications including high-resolution imaging,activatable imaging and therapy,adaptive theranostics,image-guided surgery,immunotherapy,and afterglow imaging are discussed.A brief summary and perspective in this field are also presented.We hope this review will be helpful to the researchers interested in bioprobe design and theranostic applications,and inspire new insights into the linkage between aggregate science and biomedical field. 展开更多
关键词 activatable probe AGGREGATE aggregation-induced emission intramolecular motion Jablonski diagram phototheranostics
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聚集诱导发光高分子在光学诊疗应用中的研究进展 被引量:4
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作者 李丹 孙盼盼 +3 位作者 李建高 燕赛赛 王东 唐本忠 《高分子学报》 SCIE CAS CSCD 北大核心 2022年第7期856-872,共17页
高分子因其优异的光学特性、良好的生物相容性和分子结构易于调控等优势,在光学诊疗领域表现出巨大应用潜力.然而,传统荧光分子的聚集导致荧光淬灭现象限制了其生物应用.聚集诱导发光(AIE)分子因其聚集态高效发光的优势而备受关注.本文... 高分子因其优异的光学特性、良好的生物相容性和分子结构易于调控等优势,在光学诊疗领域表现出巨大应用潜力.然而,传统荧光分子的聚集导致荧光淬灭现象限制了其生物应用.聚集诱导发光(AIE)分子因其聚集态高效发光的优势而备受关注.本文从AIE高分子的构建出发,重点介绍了D-A型共轭聚合物的构建策略、构-效关系以及相对于小分子的性能和应用优势,并从生物成像、肿瘤诊疗和抗菌三个方面总结了AIE高分子在光学诊疗领域的最新研究进展.生物成像方面主要总结了NIR-Ⅱ区AIE高分子在深部组织高分辨率荧光成像中的应用;肿瘤诊疗方面主要介绍了AIE高分子在光动力治疗、光热治疗及联合治疗中的应用;以及介绍了AIE高分子在细菌感染光动力治疗中的应用.最后对AIE高分子在光学诊疗领域的未来发展前景进行了展望. 展开更多
关键词 聚集诱导发光 高分子 光学诊疗
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Small Molecular NIR-II Fluorophores for Cancer Phototheranostics 被引量:5
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作者 Hanming Dai Qing Shen +3 位作者 Jinjun Shao Wenjun Wang Fan Gao Xiaochen Dong 《The Innovation》 2021年第1期144-163,共20页
Phototheranostics integrates deep-tissue imaging with phototherapy(containing photothermal therapy and photodynamic therapy),holding great promise in early diagnosis and precision treatment of cancers.Recently,second ... Phototheranostics integrates deep-tissue imaging with phototherapy(containing photothermal therapy and photodynamic therapy),holding great promise in early diagnosis and precision treatment of cancers.Recently,second near-infrared(NIR-II)fluorescence imaging exhibits the merits of high accuracy and specificity,as well as real-time detection.Among the NIR-II fluorophores,organic small molecular fluorophores have shown superior properties in the biocompatibility,variable structure,and tunable emission wavelength than the inorganic NIR-II materials.What’s more,some small molecular fluorophores also display excellent cytotoxicity when illuminated with the NIR laser.This review summarizes the progress of small molecular NIR-II fluorophores with different central cores for cancer phototheranostics in the past few years,focusing on the molecular structures and phototheranostic performances.Furthermore,challenges and prospects of future development toward clinical translation are discussed. 展开更多
关键词 second near-infrared(NIR-II) small molecular fluorophores cancer phototheranostics
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Building multipurpose nano-toolkit by rationally decorating NIR-Ⅱ fluorophore to meet the needs of tumor diagnosis and treatment 被引量:2
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作者 Chaoxiang Cui Jiachen Li +8 位作者 Jing Fang Yan Zhao Yuqi Zhang Shuyue Ye Anna Wang Yali Feng Qiulian Mao Hongni Qin Haibin Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第7期3478-3483,共6页
Phototheranostics have attracted tremendous attention in cancer diagnosis and treatment because of the noninvasiveness and promising effectiveness.Developing advanced phototheranostic agents with long emission wavelen... Phototheranostics have attracted tremendous attention in cancer diagnosis and treatment because of the noninvasiveness and promising effectiveness.Developing advanced phototheranostic agents with long emission wavelength,excellent biocompatibility,great tumor-targeting capability,and efficient therapeutic effect is highly desirable.However,the mutual constraint between imaging and therapeutic functions usually hinders their wide applications in biomedical field.To balance this contradiction,we herein rationally designed and synthesized three novel tumor-targeted NIR-Ⅱ probes(QR-2PEG_(321),QR-2PEG_(1000),and QR-2PEG_(5000)) by conjugating three different chain lengths of PEG onto an integrin α_(v)β_(3)-targeted NIR-Ⅱ heptamethine cyanine fluorophore,respectively.In virtue of the essential amphiphilic characteristics of PEG polymers,these probes display various degree of aggregation in aqueous buffer accompanying with differential NIR-Ⅱ imaging and photothermal(PTT) therapeutic performance.Both in vitro and in vivo results have demonstrated that probe QR-2PEG_(5000) has the best NIR-Ⅱ imaging performance with prominent renal clearance,whereas QR-2PEG_(321)possesses excellent photoacoustic signal as well as PTT effect,which undoubtedly provides a promising toolbox for tumor diagnosis and therapy.We thus envision that these synthesized probes have great potential to be explored as a toolkit for precise diagnosis and treatment of malignant tumors. 展开更多
关键词 phototheranostics NIR-Ⅱprobe Cyanine fluorophore Photoacoustic imaging Photothermal therapy
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Boron difluoride formazanate dye for high-efficiency NIR-Ⅱ fluorescence imaging-guided cancer photothermal therapy 被引量:1
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作者 Hanming Dai Zijin Cheng +6 位作者 Tian Zhang Weili Wang Jinjun Shao Wenjun Wang Yongxiang Zhao Xiaochen Dong Liping Zhong 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第5期2501-2506,共6页
The small molecular second near-infrared(NIR-Ⅱ, 1000–1700 nm) dye-based nanotheranostics can concurrently combine deep-tissue photodiagnosis with in situ phototherapy, which occupies a vital position in the early de... The small molecular second near-infrared(NIR-Ⅱ, 1000–1700 nm) dye-based nanotheranostics can concurrently combine deep-tissue photodiagnosis with in situ phototherapy, which occupies a vital position in the early detection and precise treatment of tumors. However, the development of small molecular NIR-Ⅱ dyes is still challenging due to the limited electron acceptors and cumbersome synthetic routes.Herein, we report a novel molecular electron acceptor, boron difluoride formazanate(BDF). Based on BDF, a new small molecular NIR-Ⅱ dye BDF1005 is designed and synthesized with strong NIR-I absorption at 768 nm and bright NIR-Ⅱ peak emission at 1034 nm. In vitro and in vivo experiments demonstrate that BDF1005-based nanotheranostics can be applied for NIR-Ⅱ fluorescence imaging-guided photothermal therapy of 4T1 tumor-bearing mice. Under 808 nm laser irradiation, tumor growth can be effectively inhibited. This work opens up a new road for the exploitation of NIR-Ⅱ small molecular dyes for cancer phototheranostics. 展开更多
关键词 NIR-II nanotheranostics Boron difluoride formazanate Fluorescence imaging Photothermal therapy phototheranostics
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聚合物纳米光诊疗剂的制备与应用新进展 被引量:1
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作者 郭亮 葛介超 《影像科学与光化学》 CAS CSCD 北大核心 2017年第4期445-463,共19页
共轭聚合物纳米颗粒是由π-共轭有机聚合物组成的尺寸在1~100nm范围内的新型有机纳米材料。与传统的有机小分子、半导体量子点和无机纳米材料相比,聚合物纳米颗粒具有光学性质特殊、结构多样、表面易修饰和生物相容性好等优点,因而被广... 共轭聚合物纳米颗粒是由π-共轭有机聚合物组成的尺寸在1~100nm范围内的新型有机纳米材料。与传统的有机小分子、半导体量子点和无机纳米材料相比,聚合物纳米颗粒具有光学性质特殊、结构多样、表面易修饰和生物相容性好等优点,因而被广泛应用于生物成像、传感与检测、载药和治疗等领域。本文主要围绕聚合物纳米颗粒的制备方法、性质结构和生物相容性等方面,重点介绍了聚合物纳米颗粒作为光诊疗剂在荧光成像、光声成像,以及光动力和光热治疗领域的研究进展,并对聚合物纳米颗粒的发展前景和未来面临的挑战进行了探讨。 展开更多
关键词 聚合物纳米颗粒 光诊疗 荧光成像 光声成像 光动力治疗 光热治疗
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Polycyclic naphthalenediimide-based nanoparticles for NIR-Ⅱ fluorescence imaging guided phototherapy 被引量:1
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作者 Chuanchao Tang Chuanhui Song +5 位作者 Zheng Wei Chen Liang Jianchuan Ran Yu Cai Xiaochen Dong Wei Han 《Science China Chemistry》 SCIE EI CAS CSCD 2020年第7期946-956,共11页
Optical imaging and phototherapy in the second near-infrared window(NIR-Ⅱ, 900–1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetr... Optical imaging and phototherapy in the second near-infrared window(NIR-Ⅱ, 900–1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics. Herein, a polycyclic naphthalenediimide(NDI) based chromophore 13-amino-4,5-dibromo-2,7-di(dodecan-6-yl)-1 H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone(NDI-NA) was designed and synthesized. With large polycyclic π-systems, NDI-NA molecule possesses broad near-infrared(NIR) absorption(maximum at777 nm) and emission(maximum at 921 nm). By nanoprecipitation, NDI-NA nanoparticles(NPs) were formed in aqueous solution with J-aggregative state, which showed huge red-shift in both absorption spectrum(maximum at 904 nm) and emission spectrum(maximum at 1,020 nm), endowing NDI-NA NPs efficient NIR-Ⅱ fluorescence imaging capability. Besides, the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention(EPR) effect. More importantly, NDI-NA NPs simultaneously have high photothermal conversion efficiency(30.8%) and efficient reactive oxygen species generation ability, making them remarkably phototoxic to cancer cells. The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-Ⅱ phototheranostic agents possess bright future for clinical NIR-Ⅱ imaging-guided cancer phototherapy. 展开更多
关键词 second near-infrared window fluorescence imaging PHOTOTHERAPY phototheranostics polycyclic naphthalenediimide
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A facile phototheranostic nanoplatform integrating NIR-Ⅱ fluorescence/PA bimodal imaging and image-guided surgery/PTT combinational therapy for improved antitumor efcacy
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作者 Xiuping Han Wenyou Fang +7 位作者 Tianqi Zhang Xuan Zhong Kun Qian Zhitao Jiang Rongfeng Hu Guoqiang Shao Lei Zhang Qing Zhang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2022年第35期208-218,共11页
Phototheranostic with highly integrated functions is an attractive platform for cancer management. It remains challenging to develop a facile phototheranostic platform with complementary bimodal imaging and combinatio... Phototheranostic with highly integrated functions is an attractive platform for cancer management. It remains challenging to develop a facile phototheranostic platform with complementary bimodal imaging and combinational therapy capacity. Herein, the small-molecule cyanine IR780 loaded liposomes have been harnessed as a nanoplatform to simultaneously realize photoacoustic(PA)/the second near-infrared window(NIR-Ⅱ) fluorescence imaging and image-guided surgery/adjuvant photothermal therapy(PTT).This nanoplatform exhibits attractive properties like uniform controllable size, stable dispersibility, NIR-Ⅱ fluorescence emission, photothermal conversion, and biocompatibility. Benefiting from the complementary PA/NIR-Ⅱ fluorescence bimodal imaging, this nanoplatform was successfully applied in precise vasculature delineation and tumor diagnosis. Interestingly, the tumor was clearly detected by NIR-Ⅱ fluorescence imaging with the highest tumor-to-normal-tissue ratio up to 12.69, while signal interference from the liver was significantly reduced, due to the difference in the elimination rate of the nanoplatform in the liver and tumor. Under the precise guidance of the image, the tumor was accurately resected, and the simulated residual lesion after surgery was completely ablated by adjuvant PTT. This combined therapy showed improved antitumor efcacy over the individual surgery or PTT. This work develops a facile phototheranostic nanoplatform with great significance in accurately diagnosing and effectively treating tumors using simple NIR light irradiation. 展开更多
关键词 NIR-Ⅱfluorescence imaging Photoacoustic imaging Image-guided surgery Adjuvant photothermal therapy phototheranostics
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调控供电子策略简易制备近红外二区有机小分子光学诊疗试剂
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作者 王其 夏辉 +6 位作者 熊炎威 张新敏 蔡杰 陈冲 高逸聪 陆峰 范曲立 《化学学报》 SCIE CAS CSCD 北大核心 2022年第11期1485-1493,共9页
有机小分子凭借着明确的化学结构、出色的生物相容性、优异的可重复性等诸多优势被广泛应用于光学诊疗领域.然而,目前报道的有机小分子存在合成步骤复杂、成像波长位于近红外一区(NIR-Ⅰ)、光热转换效率及单线态氧产率低等缺陷,严重限... 有机小分子凭借着明确的化学结构、出色的生物相容性、优异的可重复性等诸多优势被广泛应用于光学诊疗领域.然而,目前报道的有机小分子存在合成步骤复杂、成像波长位于近红外一区(NIR-Ⅰ)、光热转换效率及单线态氧产率低等缺陷,严重限制了其诊疗效果.基于此,本工作以吡咯并吡咯二酮作为缺电子单元、分别以苯、苯胺、邻苯二胺作为供电子单元,通过一步偶联反应简易制备得到三种有机小分子DPP-0、DPP-2、DPP-4,进一步利用纳米沉淀法制备得到对应的水溶性纳米粒子DPP-0 NPs、DPP-2 NPs和DPP-4 NPs.研究发现,随着氨基数量的增加,纳米粒子吸收/发射均发生了红移,其中DPP-4 NPs具有良好的NIR-Ⅰ吸收能力且其最大荧光发射达到了近红外二区(NIR-Ⅱ)区域,表明可以通过改变供电子单元策略实现光学性能的调控.在单一激光照射下,DPP-4 NPs可以同时产生NIR-Ⅱ荧光信号、过高热及单线态氧,其光热转换效率和单线态氧产率分别高达40.2%及34.3%,可成功应用于肿瘤深层次NIR-Ⅱ荧光成像诊断及高效光热/光动力联合治疗. 展开更多
关键词 有机小分子 光学诊疗 近红外二区荧光成像 光动力治疗 光热治疗
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Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced antitumor phototherapy in vivo
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作者 Xianghan Zhang Sumei Zhao +5 位作者 Zhiqing Gao Jialin Zhou Yuqiong Xia Jie Tian Changhong Shi Zhongliang Wang 《Nano Research》 SCIE EI CSCD 2021年第7期2432-2440,共9页
Cancer phototheranostics involving optical imaging-guided photodynamic therapy(PDT)and photothermal therapy(PTT)is a localized noninvasive approach in treating cancer.Mitochondria-targeted near-infrared(NIR)cyanines a... Cancer phototheranostics involving optical imaging-guided photodynamic therapy(PDT)and photothermal therapy(PTT)is a localized noninvasive approach in treating cancer.Mitochondria-targeted near-infrared(NIR)cyanines are excellent therapeutic photosensitizers of cancer.However,most mitochondria-targeted cyanines exist in the form of hydrophobic structures,which in vivo may cause cyanine aggregation during blood circulation,resulting in poor biocompatibility and limited therapeutic efficacy.Therefore,we developed a trade-off strategy by encapsulating mitochondria-targeted cyanines into liposomal bilayers(CyBI7-LPs),which balanced hydrophilicity that favored blood circulation and hydrophobicity that enhanced mitochondria tumor targeting.Moreover,CyBI7-LPs greatly minimized photobleaching of cyanine as self-generated reactive oxygen species(ROS)could rapidly escape from the liposomal bilayer,affording enhanced PTT/PDT efficacy.Bioorthogonal-mediated targeting strategy was further employed to improve uptake of tumor cells by modifying the liposomal surface to generate CyBI7-LPB.The CyBI7-LPB probe produced a tumor-to-background ratio(TBR)of approximately 6.4 at 24 HPI.Guiding by highly sensitive imaging resulted in excellent anti-tumor therapy outcomes using CyBI7-LPB due to the enhanced photothermal and photodynamic effects.This proposed liposomal nanoplatform exhibited a simple and robust approach as an imaging-guided synergistic anti-tumor therapeutic strategy. 展开更多
关键词 cancer phototheranostics NIR cyanine LIPOSOME mitochondria-targeted phototherapy
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Phototheranostic Nanoagents for Imaging-Guided Treatment of Oral Cancer 被引量:1
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作者 Jisen Li Yufan Zhang +3 位作者 Jiafei Qu Jing Gao Dan Ding Jing Shen 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2023年第13期1624-1636,共13页
Phototherapy showed almost a lack of drug resistance and,depending on the therapeutic effects of non-invasive light-stimulating photosensors.The side effects of phototherapy were greatly reduced compared to their trad... Phototherapy showed almost a lack of drug resistance and,depending on the therapeutic effects of non-invasive light-stimulating photosensors.The side effects of phototherapy were greatly reduced compared to their traditional equivalents.Phototheranostic nanoagents had new properties in drug delivery,biocompatibility,targeting and response,in which traditional phototheranostic drugs can not possess.Recently,a large number of relevant studies have demonstrated that photodynamic therapy(PDT)in combination with other agents and image-guided multifunctional photothermal therapy(PTT)were well suited for the treatment of oral cancer.Through the design of the nanoagents,researchers have discovered various applications for phototherapy,such as targeted release of co-packaged drugs,multifunctional imaging for diagnosis and treatment combination,accurate targeting caused by nanocarriers,and synergistic chemotherapy with phototherapy.In this paper,we first reviewed the research related to phototheranostic nanoagents for image-guided treatment of oral cancer.We tried to introduce the design concept and the treatment effect by three parts of components of phototheranostic nanoagents,categories of phototheranostic nanoagents and application of phototheranostic nanoagents.It also provided a reference for nanomaterial development and clinical applications in research of oral cancer treatment. 展开更多
关键词 phototheranostic Nanoagents Sensors Bioimaging Oral cancer Cancer treatment
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