Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and imp...Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspectsare clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.展开更多
Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thir...Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.展开更多
目的分析父方年龄对妊娠结局的影响。方法选取2011年1月至2020年12月于南山区分娩且父方年龄有记录的产妇185104例,母方年龄、民族、受教育程度校正后,使用logistic regression analysis、generalized linear model分析父方高龄与妊娠...目的分析父方年龄对妊娠结局的影响。方法选取2011年1月至2020年12月于南山区分娩且父方年龄有记录的产妇185104例,母方年龄、民族、受教育程度校正后,使用logistic regression analysis、generalized linear model分析父方高龄与妊娠不良结局的关系。结果父方年龄15~85岁,中位数31岁(四分位差,27~34岁),母方年龄14~51岁,中位数29岁(四分位差,26~32岁)。未经校正的分析显示,父方40~49岁组和≥50岁组妊娠期并发症发生率较高;父方<40岁组妊娠期并发症发生率较低。校正母方年龄和其他危险因素之后,父方年龄的增长与胎儿结构畸形、子痫前期、子痫、妊娠糖尿病、胎盘早剥、产后出血(≥500 mL)、早产、胎膜早破、死胎发病率的显著增加没有关系。结论校正分析结果提示,父方年龄对不良妊娠结局无独立影响,观察到的父方年龄的影响主要归因于母方年龄。展开更多
目的系统评价父亲年龄≥40岁对不孕夫妇体外受精-胚胎移植(In vitro fertilization-embryo transfer,IVF-ET)治疗后妊娠结局的影响。方法通过计算机检索Pub Med、EMBASE、Web of Science、中国知网、万方数据库、维普数据库和中国生物...目的系统评价父亲年龄≥40岁对不孕夫妇体外受精-胚胎移植(In vitro fertilization-embryo transfer,IVF-ET)治疗后妊娠结局的影响。方法通过计算机检索Pub Med、EMBASE、Web of Science、中国知网、万方数据库、维普数据库和中国生物医学文献数据库,收集国内外有关父亲年龄≥40岁对不孕夫妇体外IVF-ET术后妊娠、流产和活产影响的研究,采用Rev Man 5.3软件进行Meta分析。结果纳入文献11篇,其中包含父亲年龄≥40岁组872例,父亲年龄<40岁组5322例。Meta分析结果显示父亲年龄≥40岁组的妊娠率(OR=0.80,95%CI:0.69-0.93,P=0.004)、生化妊娠率(OR=0.75,95%CI:0.57-0.99,P=0.04)和临床妊娠率(OR=0.74,95%CI:0.61-0.91,P=0.004)显著低于父亲年龄<40岁组,其流产率显著高于年龄<40岁组(OR=1.62,95%CI:1.05-2.51,P=0.03),在活产率方面两组无差异(OR=0.74,95%CI:0.40-1.37,P=0.34)。结论父亲年龄≥40岁会降低不孕夫妇IVF-ET术后妊娠率,增加流产率,但是不影响活产率。展开更多
Age-specific mating incidence, sexual maturation and effect of age at mating on reproductive performance of the Parthenium beetle, Zygogramma bicolorata Pallister, was studied. Based on 50% mating incidence the calcul...Age-specific mating incidence, sexual maturation and effect of age at mating on reproductive performance of the Parthenium beetle, Zygogramma bicolorata Pallister, was studied. Based on 50% mating incidence the calculated age of sexual maturation of males and females was 10.5 and 11.1 days, respectively, which was not statistically signifi- cant. However, on the basis of age at first mating, that is, sexual maturity, females matured 2 days earlier than males. Fecundity, pre-oviposition, oviposition and post-oviposition period and female longevity appear to be influenced by female age at mating with repro- ductive performance peaking at 30 days. On the other hand, egg viability was influenced by male age and was highest when males mated at the age of 40 days. To summarise, egg production and timing of egg deposition was female age-dependent, whereas egg fertility was male age-dependent. It was also observed that females mated at a later age and laid a higher number of eggs immediately after mating than did earlier mated females. This was ostensibly in a bid to increase fitness by maximizing reproductive output in the reduced life span available. This is the first investigation on the effect of age of females at mating on reproduction in this beetle.展开更多
文摘Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspectsare clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.
文摘Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.
文摘目的系统评价父亲年龄≥40岁对不孕夫妇体外受精-胚胎移植(In vitro fertilization-embryo transfer,IVF-ET)治疗后妊娠结局的影响。方法通过计算机检索Pub Med、EMBASE、Web of Science、中国知网、万方数据库、维普数据库和中国生物医学文献数据库,收集国内外有关父亲年龄≥40岁对不孕夫妇体外IVF-ET术后妊娠、流产和活产影响的研究,采用Rev Man 5.3软件进行Meta分析。结果纳入文献11篇,其中包含父亲年龄≥40岁组872例,父亲年龄<40岁组5322例。Meta分析结果显示父亲年龄≥40岁组的妊娠率(OR=0.80,95%CI:0.69-0.93,P=0.004)、生化妊娠率(OR=0.75,95%CI:0.57-0.99,P=0.04)和临床妊娠率(OR=0.74,95%CI:0.61-0.91,P=0.004)显著低于父亲年龄<40岁组,其流产率显著高于年龄<40岁组(OR=1.62,95%CI:1.05-2.51,P=0.03),在活产率方面两组无差异(OR=0.74,95%CI:0.40-1.37,P=0.34)。结论父亲年龄≥40岁会降低不孕夫妇IVF-ET术后妊娠率,增加流产率,但是不影响活产率。
文摘Age-specific mating incidence, sexual maturation and effect of age at mating on reproductive performance of the Parthenium beetle, Zygogramma bicolorata Pallister, was studied. Based on 50% mating incidence the calculated age of sexual maturation of males and females was 10.5 and 11.1 days, respectively, which was not statistically signifi- cant. However, on the basis of age at first mating, that is, sexual maturity, females matured 2 days earlier than males. Fecundity, pre-oviposition, oviposition and post-oviposition period and female longevity appear to be influenced by female age at mating with repro- ductive performance peaking at 30 days. On the other hand, egg viability was influenced by male age and was highest when males mated at the age of 40 days. To summarise, egg production and timing of egg deposition was female age-dependent, whereas egg fertility was male age-dependent. It was also observed that females mated at a later age and laid a higher number of eggs immediately after mating than did earlier mated females. This was ostensibly in a bid to increase fitness by maximizing reproductive output in the reduced life span available. This is the first investigation on the effect of age of females at mating on reproduction in this beetle.
