跨损伤DNA合成(translesion DNA synthesis,TLS)是细胞应答DNA损伤时的一种耐受机制,它利用特异的低保真度的DNA聚合酶直接在损伤的对面合成DNA,使复制得以延续.TLS分为无错旁路和易错旁路两种途径,其中易错旁路途径是DNA损伤诱发基因...跨损伤DNA合成(translesion DNA synthesis,TLS)是细胞应答DNA损伤时的一种耐受机制,它利用特异的低保真度的DNA聚合酶直接在损伤的对面合成DNA,使复制得以延续.TLS分为无错旁路和易错旁路两种途径,其中易错旁路途径是DNA损伤诱发基因组突变的主要机制.另外TLS也与肿瘤细胞耐药性相关.在体内执行TLS功能的DNA聚合酶主要是DNA聚合酶Y家族的成员,其中包括聚合酶kappa(Polκ).就TLS的特性,哺乳动物Polκ的结构及催化活性、表达及调控、蛋白质相互作用及其在TLS中可能的调控机制和体内功能等方面做一阐述.展开更多
Competition Intensifies in Medium Segment Passenger vehicle (including van) registrations reached 524,960 in April 2007, a year-on-year increase of 22.3%. In terms of body types, sedan models continued their high grow...Competition Intensifies in Medium Segment Passenger vehicle (including van) registrations reached 524,960 in April 2007, a year-on-year increase of 22.3%. In terms of body types, sedan models continued their high growth with a year-on-year increase of 29.4%. However, hatchback models were not so promising, registering a year-on-year rise of just 4.3%.展开更多
Small Cars Struggling in the Market Passenger vehicle (including van) registrations reached 2,847,560 in the first half of 2007, a year-on-year increase of 22.1%. In terms of body types, sedan models
Competition Heating Up in the Luxury Car Market Passenger vehicle (including Van) registrations hit a record high in January 2008,reaching 782,700,a year-on-year increase of 27.6%.
Hatchback Has Long Way to Go Passenger vehicle (including van) registrations reached 417,515 in May 2007, a year-on-year increase of 22.5%. In terms of body types, sedan models continued their rapid growth with a year...Hatchback Has Long Way to Go Passenger vehicle (including van) registrations reached 417,515 in May 2007, a year-on-year increase of 22.5%. In terms of body types, sedan models continued their rapid growth with a year-on-year increase of 33.9%. The situation of hatchback展开更多
Polk Audio(普乐之声）是美国扬声器领域数一数二的头牌级厂商，围绕着音响产品领域，该公司拥有55种世界级专利，特别在家用高级音响和汽车音响方面威名素卓。外形华丽之至的1-Sonic是一套全能的数字娱乐系统，可收听HD Radio（高清晰...Polk Audio(普乐之声）是美国扬声器领域数一数二的头牌级厂商，围绕着音响产品领域，该公司拥有55种世界级专利，特别在家用高级音响和汽车音响方面威名素卓。外形华丽之至的1-Sonic是一套全能的数字娱乐系统，可收听HD Radio（高清晰数字广播）信号和卫星无线电XM是其主打卖点之一。展开更多
Polk Audio顶级家用扬声器LSiM系列，包括落地式、书架式、中置声道和环绕声道多个型号，采用Polk“动态平衡”（DYnamiC Balance）设计技术的顶级声学换能器，将最新的复合材料和计算机辅助设计的外形结合起来，使得驱动器的声音具有...Polk Audio顶级家用扬声器LSiM系列，包括落地式、书架式、中置声道和环绕声道多个型号，采用Polk“动态平衡”（DYnamiC Balance）设计技术的顶级声学换能器，将最新的复合材料和计算机辅助设计的外形结合起来，使得驱动器的声音具有极低的失真和极少的人工处理痕迹；并采用了Polk最先进的材料工程技术，例如超级透气窝形的聚丙烯锥盆可以减少锥盆的重量并降低因锥盆重量造成的失真。展开更多
《Goodnight Safari》开发商：Polk Street PressLLC产品系统：与iPhone、iPad、iPodtouch兼容适合年龄：2～5岁编辑推荐：这是一款由著名插画师Lucian NavarroPowell设计的晚安动画书，因其精致而生动的设计获得无数专业媒体的赞誉。...《Goodnight Safari》开发商：Polk Street PressLLC产品系统：与iPhone、iPad、iPodtouch兼容适合年龄：2～5岁编辑推荐：这是一款由著名插画师Lucian NavarroPowell设计的晚安动画书，因其精致而生动的设计获得无数专业媒体的赞誉。里面包含了7个非洲大草原的场景，每个场景都对应一个不同的动物。夜晚到了，小动物们都要睡觉了。展开更多
文摘跨损伤DNA合成(translesion DNA synthesis,TLS)是细胞应答DNA损伤时的一种耐受机制,它利用特异的低保真度的DNA聚合酶直接在损伤的对面合成DNA,使复制得以延续.TLS分为无错旁路和易错旁路两种途径,其中易错旁路途径是DNA损伤诱发基因组突变的主要机制.另外TLS也与肿瘤细胞耐药性相关.在体内执行TLS功能的DNA聚合酶主要是DNA聚合酶Y家族的成员,其中包括聚合酶kappa(Polκ).就TLS的特性,哺乳动物Polκ的结构及催化活性、表达及调控、蛋白质相互作用及其在TLS中可能的调控机制和体内功能等方面做一阐述.
文摘Competition Intensifies in Medium Segment Passenger vehicle (including van) registrations reached 524,960 in April 2007, a year-on-year increase of 22.3%. In terms of body types, sedan models continued their high growth with a year-on-year increase of 29.4%. However, hatchback models were not so promising, registering a year-on-year rise of just 4.3%.
文摘Small Cars Struggling in the Market Passenger vehicle (including van) registrations reached 2,847,560 in the first half of 2007, a year-on-year increase of 22.1%. In terms of body types, sedan models
文摘Competition Heating Up in the Luxury Car Market Passenger vehicle (including Van) registrations hit a record high in January 2008,reaching 782,700,a year-on-year increase of 27.6%.
文摘Hatchback Has Long Way to Go Passenger vehicle (including van) registrations reached 417,515 in May 2007, a year-on-year increase of 22.5%. In terms of body types, sedan models continued their rapid growth with a year-on-year increase of 33.9%. The situation of hatchback
文摘《Goodnight Safari》开发商：Polk Street PressLLC产品系统：与iPhone、iPad、iPodtouch兼容适合年龄：2～5岁编辑推荐：这是一款由著名插画师Lucian NavarroPowell设计的晚安动画书，因其精致而生动的设计获得无数专业媒体的赞誉。里面包含了7个非洲大草原的场景，每个场景都对应一个不同的动物。夜晚到了，小动物们都要睡觉了。
