The development and application of systems strategies to biology and disease are transforming medical research and clinical practice in an unprecedented rate. In the foreseeable future, clinicians, medical researchers...The development and application of systems strategies to biology and disease are transforming medical research and clinical practice in an unprecedented rate. In the foreseeable future, clinicians, medical researchers, and ultimately the consumers and patients will be increasingly equipped with a deluge of personal health information, e.g., whole genome sequences, molecular profiling of diseased tissues, and periodic multi-analyte blood testing of biomarker panels for disease and wellness. The convergence of these practices will enable accurate prediction of disease susceptibility and early diagnosis for actionable preventive schema and personalized treatment regimes tailored to each individual. It will also entail proactive participation from all major stakeholders in the health care system. We are at the dawn of predictive, preventive, personalized, and participatory （P4） medicine, the fully implementation of which requires marrying basic and clinical researches through advanced systems thinking and the employment of high-throughput technologies in genomics, pro- teomics, nanofluidics, single-cell analysis, and computation strategies in a highly-orchestrated discipline we termed translational systems medicine.展开更多
Yellow phosphorus tail gas is a resource used to produce bulk chemicals, such as formates, oxalates, and methanol after its pretreatment and purification. In this study, catalytic oxidation of phosphorus and hydrogen ...Yellow phosphorus tail gas is a resource used to produce bulk chemicals, such as formates, oxalates, and methanol after its pretreatment and purification. In this study, catalytic oxidation of phosphorus and hydrogen sulfide in yellow phosphorus tail gas was investigated on an ordinary activated carbon (OAC) and a home made catalyst KU2. The adsorption characteristics of phosphorus and hydrogen sulfide on the catalysts were studied in a fixed-bed system at different temperatures between 20℃ and 140℃ at atmospheric pressure. Both KU2 and OAC are proved to be effective catalysts in the catalytic oxidation process (COP) for H 2S and PH 3 removal. Purification efficiency increased with the increase of temperature and oxygen concentration in yellow phosphorus tail gases. Under optimized operation conditions, the product gases with a content of hydrogen sulfide<5 mg/m 3 and total phosphorus<5 mg/m 3 were obtained by using the COP process. Deactivated catalysts could be restored to the original activated state, even after several regenerations. A mathematical model was developed to simulate the experimental results and the mass transport coefficient from the experiment was evaluated. Good agreement between the experimental breakthrough curves and the model predictions was observed.展开更多
基金the Grand Duchy of Luxembourg,NIH/NCI NanoSystems Biology Cancer Center(Grant No.U54 CA151819A)NIH/NIGMS Center for Systems Biology(Grant No.P50GM076547)NIH/NIAMSD(Grant No.RC2AR059010)
文摘The development and application of systems strategies to biology and disease are transforming medical research and clinical practice in an unprecedented rate. In the foreseeable future, clinicians, medical researchers, and ultimately the consumers and patients will be increasingly equipped with a deluge of personal health information, e.g., whole genome sequences, molecular profiling of diseased tissues, and periodic multi-analyte blood testing of biomarker panels for disease and wellness. The convergence of these practices will enable accurate prediction of disease susceptibility and early diagnosis for actionable preventive schema and personalized treatment regimes tailored to each individual. It will also entail proactive participation from all major stakeholders in the health care system. We are at the dawn of predictive, preventive, personalized, and participatory （P4） medicine, the fully implementation of which requires marrying basic and clinical researches through advanced systems thinking and the employment of high-throughput technologies in genomics, pro- teomics, nanofluidics, single-cell analysis, and computation strategies in a highly-orchestrated discipline we termed translational systems medicine.
基金"8 63"HighTechnologyPlanningGrant (No .2 0 0 4AA64 90 40 ) NationalNaturalScienceFund (No .5 3 0 0 2 3 45 ) NaturalScienceFundofYunnanProvince (No .2 0 0 2E0 0 0 9Q )
文摘Yellow phosphorus tail gas is a resource used to produce bulk chemicals, such as formates, oxalates, and methanol after its pretreatment and purification. In this study, catalytic oxidation of phosphorus and hydrogen sulfide in yellow phosphorus tail gas was investigated on an ordinary activated carbon (OAC) and a home made catalyst KU2. The adsorption characteristics of phosphorus and hydrogen sulfide on the catalysts were studied in a fixed-bed system at different temperatures between 20℃ and 140℃ at atmospheric pressure. Both KU2 and OAC are proved to be effective catalysts in the catalytic oxidation process (COP) for H 2S and PH 3 removal. Purification efficiency increased with the increase of temperature and oxygen concentration in yellow phosphorus tail gases. Under optimized operation conditions, the product gases with a content of hydrogen sulfide<5 mg/m 3 and total phosphorus<5 mg/m 3 were obtained by using the COP process. Deactivated catalysts could be restored to the original activated state, even after several regenerations. A mathematical model was developed to simulate the experimental results and the mass transport coefficient from the experiment was evaluated. Good agreement between the experimental breakthrough curves and the model predictions was observed.
