摘要
Micro RNA(miRNA)作为重要的后转录调节因子参与多种生理活动。孕酮(Progesterone,P4)是重要的甾类激素,通过结合特异性受体——孕酮受体(Progesterone receptors,PGR)发挥生理作用。PGR作为核受体超家族的一员参与调控生殖相关组织或非生殖相关组织的功能。P4/PGR和miRNA可单独在雌性生殖中发挥调控作用。然而,在雌性生殖过程中,miRNA和P4/PGR的相互作用对调控排卵等雌性生殖活动起到非常重要的作用,但作用机制还未阐明。本文综述了mi RNA调节P4产生、PGR基因表达以及P4/PGR调节miRNA表达的可能作用方式,为更好地研究mi RNA和P4/PGR在雌性生殖中的作用提供理论基础。
Micro RNAs（mi RNAs） are involved in several physiological processes as important post-transcriptional regulators. Progesterone（P4）, an important steroid hormone, produces physiological effect through binding specific receptor progesterone receptors（PGR） which regulates functions of both reproductive and non-reproductive tissues as a member of the nuclear receptor superfamily. P4/PGR and mi RNAs could regulate female reproduction independently, however, it is still unclear how mi RNAs and P4/PGR interaction regulates female reproductive activities such as ovulation in female reproduction. In this review, we summarize the possible ways inwhich mi RNAs regulate P4 production and PGR gene expression as well as P4/PGR regulate mi RNAs expression,which provide a theoretical basis for further studying the role of mi RNAs and P4/PGR in female reproduction.
出处
《遗传》
CAS
CSCD
北大核心
2016年第1期40-51,共12页
Hereditas（Beijing)
基金
国家自然科学基金面上项目(编号:31372287)
国家发改委重大专项(编号:2014-2573)
国家科技重大专项(编号:2014ZX0800952B)
中国农业科学院科技创新工程(编号:ASTIP-IAS13)资助~~
关键词
MIRNA
P4
孕酮受体
雌性生殖
miRNA
progesterone
progesterone receptor
female reproduction
