目的探索职业压力与男性警察血三酰甘油(triglyceride,TG)的关系,为男性警察高三酰甘油血症(hypertriglyceridemia,HTG)的预防提供依据。方法从Dryad数据库中提取意大利一警察部队男性警察前瞻性队列研究的相关数据进行二次分析,2009至2...目的探索职业压力与男性警察血三酰甘油(triglyceride,TG)的关系,为男性警察高三酰甘油血症(hypertriglyceridemia,HTG)的预防提供依据。方法从Dryad数据库中提取意大利一警察部队男性警察前瞻性队列研究的相关数据进行二次分析,2009至2014年的5年时间里通过要求-控制-支持(demand control support,DCS)模型评估职业压力大小,于2009年1月和2014年1月分别测量TG、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、空腹血糖、体质量指数、腰围。通过多元线性回归分析职业压力与TG的关系。使用阈值效应分析职业压力对TG影响的阈值。结果该研究共纳入男性警察199名,经过5年的随访,7名确诊HTG,其中高职业压力组有6名(发病率8.45%),与中低职业压力组1名(发病率0.78%)相比,差异有统计学意义(P<0.01);在校正年龄、失眠、吸烟、基线肥胖、基线TG、基线HDL-C后,随职业压力等级的增加,TG逐步增加的趋势具有统计学意义(趋势性检验P<0.01)。TG与工作要求评分呈正相关,与工作控制呈负相关,差异均有统计学意义(均P<0.01)。阈值效应分析显示当职业压力评分≥1.11时,职业压力每增加1,TG增加11.44 mg/dL(P<0.01)。结论高职业压力与男性警察TG升高相关。展开更多
Objective This study aimed to evaluate the association between occupational radiation exposure and changes in thyroid hormone levels among medical radiation workers.Methods This retrospective cohort study included 2,9...Objective This study aimed to evaluate the association between occupational radiation exposure and changes in thyroid hormone levels among medical radiation workers.Methods This retrospective cohort study included 2,946 radiation workers from 20 Guangzhou hospitals.Data on general characteristics,participant radiation dosimetry,and thyroid function test results[thyroid-stimulating hormone(TSH),triiodothyronine(T3),and thyroid hormone(T4)]were extracted from dosimetry and medical records.The generalized estimating equation was used to evaluate the trend of changes in thyroid hormone levels over time and was adjusted for age,gender,and occupation.Results The average annual effective dose was very low and showed a general downward trend.During the follow-up period,changes in T3 and T4 levels among radiation workers were-0.015[95% confidence interval(CI)-0.018 to-0.012]nmol/L per year and-2.294(95%CI-2.426 to-2.162)nmol/L per year,respectively.Thyroid hormone levels were significantly different between males and females.T3 levels in the group of upper quartile of dose were significantly higher than in the lower quartile group(P=0.006).No significant decreased trend in thyroid hormone levels was observed with increasing average effective doses.Conclusion Thyroid hormone secretion might be affected even in low-dose radiation exposure environments.展开更多
文摘目的探索职业压力与男性警察血三酰甘油(triglyceride,TG)的关系,为男性警察高三酰甘油血症(hypertriglyceridemia,HTG)的预防提供依据。方法从Dryad数据库中提取意大利一警察部队男性警察前瞻性队列研究的相关数据进行二次分析,2009至2014年的5年时间里通过要求-控制-支持(demand control support,DCS)模型评估职业压力大小,于2009年1月和2014年1月分别测量TG、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、空腹血糖、体质量指数、腰围。通过多元线性回归分析职业压力与TG的关系。使用阈值效应分析职业压力对TG影响的阈值。结果该研究共纳入男性警察199名,经过5年的随访,7名确诊HTG,其中高职业压力组有6名(发病率8.45%),与中低职业压力组1名(发病率0.78%)相比,差异有统计学意义(P<0.01);在校正年龄、失眠、吸烟、基线肥胖、基线TG、基线HDL-C后,随职业压力等级的增加,TG逐步增加的趋势具有统计学意义(趋势性检验P<0.01)。TG与工作要求评分呈正相关,与工作控制呈负相关,差异均有统计学意义(均P<0.01)。阈值效应分析显示当职业压力评分≥1.11时,职业压力每增加1,TG增加11.44 mg/dL(P<0.01)。结论高职业压力与男性警察TG升高相关。
基金supported by grants from the National Natural Science Foundation of China[81860604]Guangdong Science and Technology Program[2016A020215162]Innovating Strong School Project of Guangdong Pharmaceutical University[51359046]。
文摘Objective This study aimed to evaluate the association between occupational radiation exposure and changes in thyroid hormone levels among medical radiation workers.Methods This retrospective cohort study included 2,946 radiation workers from 20 Guangzhou hospitals.Data on general characteristics,participant radiation dosimetry,and thyroid function test results[thyroid-stimulating hormone(TSH),triiodothyronine(T3),and thyroid hormone(T4)]were extracted from dosimetry and medical records.The generalized estimating equation was used to evaluate the trend of changes in thyroid hormone levels over time and was adjusted for age,gender,and occupation.Results The average annual effective dose was very low and showed a general downward trend.During the follow-up period,changes in T3 and T4 levels among radiation workers were-0.015[95% confidence interval(CI)-0.018 to-0.012]nmol/L per year and-2.294(95%CI-2.426 to-2.162)nmol/L per year,respectively.Thyroid hormone levels were significantly different between males and females.T3 levels in the group of upper quartile of dose were significantly higher than in the lower quartile group(P=0.006).No significant decreased trend in thyroid hormone levels was observed with increasing average effective doses.Conclusion Thyroid hormone secretion might be affected even in low-dose radiation exposure environments.
