1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee o...1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.展开更多
作为一种管理思想和手段,学校改进规划(School Development Planning)受到了教育界的广泛关注并应用于各项教育改革之中。伴随着公共教育管理体制改革,加拿大安大略省教育质量和责任办公室(EQAO)发布《学校和董事会改进规划指南》,包含...作为一种管理思想和手段,学校改进规划(School Development Planning)受到了教育界的广泛关注并应用于各项教育改革之中。伴随着公共教育管理体制改革,加拿大安大略省教育质量和责任办公室(EQAO)发布《学校和董事会改进规划指南》,包含树立意识、聚焦数据、问责沟通、制定文本、后续保障五部分内容,为加国安省中小学改进规划的制定与推行提供了良好范本与指导,展现了安省民主化、个性化、科学化的教育管理体系以及更加公平、自主的教育价值取向。展开更多
Climate change has an impact on various climatic variables. In this study our focus is mainly on temperature characteristics of climate parameter. In temperate and humid regions like southern Ontario, the effect of cl...Climate change has an impact on various climatic variables. In this study our focus is mainly on temperature characteristics of climate parameter. In temperate and humid regions like southern Ontario, the effect of climate change on Frost-free days in winter is distinctive. The average annual temperature is going upward but the extreme increase is in the winter temperature. Winter average temperature is going up by about 2˚C. However, extreme daily minimum temperature is going up by more than 3˚C. This climate effect has a great impact on the nature of precipitation and length of frost-free days. The snowfall over winter months is decreasing and the rainfall is increasing. However, the number of frost-free days during late fall months, early winter months, late winter months and early spring months are increasing. This result reveals an increase in length of the growing season. This research focuses on the effect of change in climatic variables on Frost-free days in Southern Ontario. Therefore, special attention should be given to the effect of change in climate Frost-free conditions on length of crop growing in winter season for potential investigation.展开更多
Objective: Analysis of clinical documents such as bone mineral density (BMD) reports is an important component of program evaluation because it can provide insights into the accuracy of assessment of fracture risk com...Objective: Analysis of clinical documents such as bone mineral density (BMD) reports is an important component of program evaluation because it can provide insights into the accuracy of assessment of fracture risk communicated to patients and practitioners. Our objective was to compare fracture risk calculations from BMD test reports to those based on the 2010 Canadian guidelines. Methods: We retrieved BMD reports from fragility fracture patients screened through a community hospital fracture clinic participating in Ontario’s Fracture Clinic Screening Program. Fracture risk was determined according to the 2010 Canadian guidelines using age, sex, and T-score at the femoral neck, in addition to three clinical factors. Three researchers classified patients’ fracture risk until consensus was achieved. Results: We retrieved reports for 17 patients from nine different BMD clinics in the Greater Toronto Area. Each patient had a different primary care physician and all BMD tests were conducted after the 2010 Canadian guidelines were published. The fracture risk of 10 patients was misclassified with 9 of the 10 reports underestimating fracture risk. Nine reports acknowledged that the prevalence of a fragility fracture raised the risk category by one level but only four of these reports acknowledged that the patient had, or may have sustained, a fragility fracture. When we raised fracture risk by one level according to these reports, eight patients were still misclassified. Fracture risk in the majority of these patients remained underestimated. Inconsistent classification was found in the majority of cases where reports came from the same clinic. Four reports described risk levels for two different types of risk. Conclusions: More than half of patients received BMD reports which underestimated fracture risk. Bone health management recommendations based on falsely low fracture risk are likely to be sub-optimal.展开更多
Fish from the Great Lakes contain polychlorinated biphenyls（PCBs）which have been shown to disrupt endocrine function and mimic thyroid hormones,but they also contain beneficial omega-3 fatty acids that may offer pro...Fish from the Great Lakes contain polychlorinated biphenyls（PCBs）which have been shown to disrupt endocrine function and mimic thyroid hormones,but they also contain beneficial omega-3 fatty acids that may offer protection against endocrine cancers.The purpose of this study was to examine the effects of Lake Ontario fish consumption and the estimated consumption of PCBs and omega-3 fatty acids on the risk of thyroid cancer in a group of sport fishermen.Anglers from the New York State Angler Cohort Study were followed for cancer incidence from 1991–2008.Twenty-seven cases of incident thyroid cancer and 108 controls were included in the analyses.Total estimated fish consumption,estimated omega-3 fatty acid consumption,and estimated PCB consumption from Lake Ontario fish were examined for an association with the incidence of thyroid cancer,while matching on sex,and controlling for age and smoking status.Results from logistic regression indicate no significant associations between fish consumption,short-term estimated omega-3 fatty acids,or estimated PCB consumption from Great Lakes fish and the development of thyroid cancer,but it was suggested that long-term omega-3 fatty acid from Great Lakes fish may be protective of the development of thyroid cancer.In conclusion,fish consumption,with the possible concomitant PCBs,from the Great Lakes does not appear to increase the risk of thyroid cancer in New York anglers.Further research is needed in order to separate the individual health effects of PCBs from omega-3 fatty acids contained within the fish.展开更多
The paper forms the first part of an introduction to possible impacts of climate change on daily streamflow and extremes in the Province of Ontario, Canada. In this study, both conceptual and statistical streamflow si...The paper forms the first part of an introduction to possible impacts of climate change on daily streamflow and extremes in the Province of Ontario, Canada. In this study, both conceptual and statistical streamflow simulation modeling theories were collectively applied to simulate daily streamflow volumes. Based on conceptual rainfall-runoff modeling principle, the predictors were selected to take into account several physical factors that affect streamflow, such as (1) current and previous quantities of rainfall over the watershed, (2) an index of pre-storm moisture conditions, (3) an index of pre-storm evapotranspiration capacities, and (4) a seasonal factor representing seasonal variation of streamflow volume. These rainfall-runoff conceptual factors were applied to an autocorrelation correction regression procedure to develop a daily streamflow simulation model for each of the four selected river basins. The streamflow simulation models were validated using a leave-one-year-out cross-validation scheme. The simulation models identified that the explanatory predictors are consistent with the physical processes typically associated with high-streamflow events. Daily streamflow simulation models show that there are significant correlations between daily streamflow observations and model validations, with model R2s of 0.68-0.71, 0.61-0.62, 0.71-0.74, and 0.95 for Grand, Humber, Upper Thames, and Rideau River Basins, respectively. The major reason for the model performance varying across the basins might be that rainfall-runoff response time and physical characteristics differ significantly among the selected river basins. The results suggest that streamflow simulation models can be used to assess possible impacts of climate change on daily streamflow and extremes at a local scale, which is major objective of a companion paper (Part II).展开更多
The paper forms the second part of an introduction to possible impacts of climate change on daily streamflow and extremes in the Province of Ontario, Canada. Daily streamflow simulation models developed in the compani...The paper forms the second part of an introduction to possible impacts of climate change on daily streamflow and extremes in the Province of Ontario, Canada. Daily streamflow simulation models developed in the companion paper (Part I) were used to project changes in frequency of future daily streamflow events. To achieve this goal, future climate information (including rainfall) at a local scale is needed. A regression-based downscaling method was employed to downscale eight global climate model (GCM) simulations (scenarios A2 and B1) to selected weather stations for various meteorological variables (except rainfall). Future daily rainfall quantities were projected using daily rainfall simulation models with downscaled future climate information. Following these projections, future daily streamflow volumes can be projected by applying daily streamflow simulation models. The frequency of future daily high-streamflow events in the warm season (May–November) was projected to increase by about 45%-55% late this century from the current condition, on average of eight-GCM A2 projections and four selected river basins. The corresponding increases for future daily low-streamflow events and future daily mean streamflow volume could be about 25%-90% and 10%-20%, respectively. In addition, the return values of annual one-day maximum streamflow volume for various return periods were projected to increase by 20%-40%, 20%-50%, and 30%-80%, respectively for the periods 2001-50, 2026-75, and 2051-2100. Inter-GCM and interscenario uncertainties of future streamflow projections were quantitatively assessed. On average, the projected percentage increases in frequency of future daily high-streamflow events are about 1.4-2.2 times greater than inter-GCM and interscenario uncertainties.展开更多
The in-situ instrumentation technique for measuring mercury and itsspeciation downstream a utility 100 MW pulverized coal (PC) fired boiler system was developed andconducted by the use of the Ontario hydro method (OHM...The in-situ instrumentation technique for measuring mercury and itsspeciation downstream a utility 100 MW pulverized coal (PC) fired boiler system was developed andconducted by the use of the Ontario hydro method (OHM) consistent with American standard test methodtogether with the semi-continuous emissions monitoring (SCEM) system as well as a mobile laboratoryfor mercury monitoring. The mercury and its speciation concentrations including participate mercuryat three locations of before air preheater, before electrostatic precipitator (ESP) and after ESPwere measured using the OHM and SCEM methods under normal operation conditions of the boiler systemas a result of firing a bituminous coal. The vapor-phase total mercury Hg(VT) concentration declinedwith the decrease of flue gas temperature because of mercury species transformation from oxidizedmercury to particulate mercury as the flue gas moved downstream from the air preheater to the ESPand after the ESP. A good agreement for Hg°, Hg^(2+) and Hg( VT) was obtained between the twomethods in the ash-free area. But in the dense particle-laden flue gas area, there appeared to be abig bias for mercury speciation owing to dust cake formed in the filter of OHM sampling probe. Theparticulateaffinity to the flue gas mercury and the impacts of sampling condition to accuracy ofmeasure were discussed.展开更多
文摘1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.
文摘作为一种管理思想和手段,学校改进规划(School Development Planning)受到了教育界的广泛关注并应用于各项教育改革之中。伴随着公共教育管理体制改革,加拿大安大略省教育质量和责任办公室(EQAO)发布《学校和董事会改进规划指南》,包含树立意识、聚焦数据、问责沟通、制定文本、后续保障五部分内容,为加国安省中小学改进规划的制定与推行提供了良好范本与指导,展现了安省民主化、个性化、科学化的教育管理体系以及更加公平、自主的教育价值取向。
文摘Climate change has an impact on various climatic variables. In this study our focus is mainly on temperature characteristics of climate parameter. In temperate and humid regions like southern Ontario, the effect of climate change on Frost-free days in winter is distinctive. The average annual temperature is going upward but the extreme increase is in the winter temperature. Winter average temperature is going up by about 2˚C. However, extreme daily minimum temperature is going up by more than 3˚C. This climate effect has a great impact on the nature of precipitation and length of frost-free days. The snowfall over winter months is decreasing and the rainfall is increasing. However, the number of frost-free days during late fall months, early winter months, late winter months and early spring months are increasing. This result reveals an increase in length of the growing season. This research focuses on the effect of change in climatic variables on Frost-free days in Southern Ontario. Therefore, special attention should be given to the effect of change in climate Frost-free conditions on length of crop growing in winter season for potential investigation.
文摘Objective: Analysis of clinical documents such as bone mineral density (BMD) reports is an important component of program evaluation because it can provide insights into the accuracy of assessment of fracture risk communicated to patients and practitioners. Our objective was to compare fracture risk calculations from BMD test reports to those based on the 2010 Canadian guidelines. Methods: We retrieved BMD reports from fragility fracture patients screened through a community hospital fracture clinic participating in Ontario’s Fracture Clinic Screening Program. Fracture risk was determined according to the 2010 Canadian guidelines using age, sex, and T-score at the femoral neck, in addition to three clinical factors. Three researchers classified patients’ fracture risk until consensus was achieved. Results: We retrieved reports for 17 patients from nine different BMD clinics in the Greater Toronto Area. Each patient had a different primary care physician and all BMD tests were conducted after the 2010 Canadian guidelines were published. The fracture risk of 10 patients was misclassified with 9 of the 10 reports underestimating fracture risk. Nine reports acknowledged that the prevalence of a fragility fracture raised the risk category by one level but only four of these reports acknowledged that the patient had, or may have sustained, a fragility fracture. When we raised fracture risk by one level according to these reports, eight patients were still misclassified. Fracture risk in the majority of these patients remained underestimated. Inconsistent classification was found in the majority of cases where reports came from the same clinic. Four reports described risk levels for two different types of risk. Conclusions: More than half of patients received BMD reports which underestimated fracture risk. Bone health management recommendations based on falsely low fracture risk are likely to be sub-optimal.
基金funded,in part,through grants from the Great Lakes Protection Fund(no.RM791-3021)the Agency for Toxic Substances and Disease Registry(nos.H75/ATH298338 and R01TS000077)
文摘Fish from the Great Lakes contain polychlorinated biphenyls（PCBs）which have been shown to disrupt endocrine function and mimic thyroid hormones,but they also contain beneficial omega-3 fatty acids that may offer protection against endocrine cancers.The purpose of this study was to examine the effects of Lake Ontario fish consumption and the estimated consumption of PCBs and omega-3 fatty acids on the risk of thyroid cancer in a group of sport fishermen.Anglers from the New York State Angler Cohort Study were followed for cancer incidence from 1991–2008.Twenty-seven cases of incident thyroid cancer and 108 controls were included in the analyses.Total estimated fish consumption,estimated omega-3 fatty acid consumption,and estimated PCB consumption from Lake Ontario fish were examined for an association with the incidence of thyroid cancer,while matching on sex,and controlling for age and smoking status.Results from logistic regression indicate no significant associations between fish consumption,short-term estimated omega-3 fatty acids,or estimated PCB consumption from Great Lakes fish and the development of thyroid cancer,but it was suggested that long-term omega-3 fatty acid from Great Lakes fish may be protective of the development of thyroid cancer.In conclusion,fish consumption,with the possible concomitant PCBs,from the Great Lakes does not appear to increase the risk of thyroid cancer in New York anglers.Further research is needed in order to separate the individual health effects of PCBs from omega-3 fatty acids contained within the fish.
文摘The paper forms the first part of an introduction to possible impacts of climate change on daily streamflow and extremes in the Province of Ontario, Canada. In this study, both conceptual and statistical streamflow simulation modeling theories were collectively applied to simulate daily streamflow volumes. Based on conceptual rainfall-runoff modeling principle, the predictors were selected to take into account several physical factors that affect streamflow, such as (1) current and previous quantities of rainfall over the watershed, (2) an index of pre-storm moisture conditions, (3) an index of pre-storm evapotranspiration capacities, and (4) a seasonal factor representing seasonal variation of streamflow volume. These rainfall-runoff conceptual factors were applied to an autocorrelation correction regression procedure to develop a daily streamflow simulation model for each of the four selected river basins. The streamflow simulation models were validated using a leave-one-year-out cross-validation scheme. The simulation models identified that the explanatory predictors are consistent with the physical processes typically associated with high-streamflow events. Daily streamflow simulation models show that there are significant correlations between daily streamflow observations and model validations, with model R2s of 0.68-0.71, 0.61-0.62, 0.71-0.74, and 0.95 for Grand, Humber, Upper Thames, and Rideau River Basins, respectively. The major reason for the model performance varying across the basins might be that rainfall-runoff response time and physical characteristics differ significantly among the selected river basins. The results suggest that streamflow simulation models can be used to assess possible impacts of climate change on daily streamflow and extremes at a local scale, which is major objective of a companion paper (Part II).
文摘The paper forms the second part of an introduction to possible impacts of climate change on daily streamflow and extremes in the Province of Ontario, Canada. Daily streamflow simulation models developed in the companion paper (Part I) were used to project changes in frequency of future daily streamflow events. To achieve this goal, future climate information (including rainfall) at a local scale is needed. A regression-based downscaling method was employed to downscale eight global climate model (GCM) simulations (scenarios A2 and B1) to selected weather stations for various meteorological variables (except rainfall). Future daily rainfall quantities were projected using daily rainfall simulation models with downscaled future climate information. Following these projections, future daily streamflow volumes can be projected by applying daily streamflow simulation models. The frequency of future daily high-streamflow events in the warm season (May–November) was projected to increase by about 45%-55% late this century from the current condition, on average of eight-GCM A2 projections and four selected river basins. The corresponding increases for future daily low-streamflow events and future daily mean streamflow volume could be about 25%-90% and 10%-20%, respectively. In addition, the return values of annual one-day maximum streamflow volume for various return periods were projected to increase by 20%-40%, 20%-50%, and 30%-80%, respectively for the periods 2001-50, 2026-75, and 2051-2100. Inter-GCM and interscenario uncertainties of future streamflow projections were quantitatively assessed. On average, the projected percentage increases in frequency of future daily high-streamflow events are about 1.4-2.2 times greater than inter-GCM and interscenario uncertainties.
文摘The in-situ instrumentation technique for measuring mercury and itsspeciation downstream a utility 100 MW pulverized coal (PC) fired boiler system was developed andconducted by the use of the Ontario hydro method (OHM) consistent with American standard test methodtogether with the semi-continuous emissions monitoring (SCEM) system as well as a mobile laboratoryfor mercury monitoring. The mercury and its speciation concentrations including participate mercuryat three locations of before air preheater, before electrostatic precipitator (ESP) and after ESPwere measured using the OHM and SCEM methods under normal operation conditions of the boiler systemas a result of firing a bituminous coal. The vapor-phase total mercury Hg(VT) concentration declinedwith the decrease of flue gas temperature because of mercury species transformation from oxidizedmercury to particulate mercury as the flue gas moved downstream from the air preheater to the ESPand after the ESP. A good agreement for Hg°, Hg^(2+) and Hg( VT) was obtained between the twomethods in the ash-free area. But in the dense particle-laden flue gas area, there appeared to be abig bias for mercury speciation owing to dust cake formed in the filter of OHM sampling probe. Theparticulateaffinity to the flue gas mercury and the impacts of sampling condition to accuracy ofmeasure were discussed.
