The effective detecting ONOO^(-)variations in vivo is of great importance to well understand the complex pathophysiological processes. We reported here a photoacoustic(PA) probe AZB-1 for imaging ONOO;in vivo. AZB-1 s...The effective detecting ONOO^(-)variations in vivo is of great importance to well understand the complex pathophysiological processes. We reported here a photoacoustic(PA) probe AZB-1 for imaging ONOO;in vivo. AZB-1 showed an originally strong photoacoustic signal at 660 nm. And its PA signal can be turned off by shutting the ICT effect caused by the conjugated electron withdrawing group at 2-position of the aza-BODIPY core. Moreover, the probe was successfully employed to imaging ONOO^(-)variations in inflammatory mice models. Wisely utilized this strategy may serve as powerful platforms for the preparation of novel PA chemosensors.展开更多
Phototherapies including photodynamic therapy(PDT)and photothermal therapy(PTT)are the most promising and non-invasive cancer treatments.However,the efficacy of mono-therapy of PDT or PTT is often limited by the photo...Phototherapies including photodynamic therapy(PDT)and photothermal therapy(PTT)are the most promising and non-invasive cancer treatments.However,the efficacy of mono-therapy of PDT or PTT is often limited by the phototherapeutic defects such as low light penetration depth of photosensitizers and insufficiency of photothermal agents.Peroxynitrite(ONOO−)has been proved to be an efficient oxidizing and nitrating agent that involves in various physiological and pathological processes.Therefore,ONOO−produced in tumor site could be an effective treatment in cancer therapy.Herein,a novel cyanine dye-based(Cy7)polymer nanoplatform is developed for enhanced phototherapy by in situ producing ONOO−.The Cy7 units in the nanoparticles can not only be served as the photosensitizer to produce reactive oxygen species(ROS)including singlet oxygen and superoxide anion for PDT,but also be used as a heat source for PTT and the release of NO gas from N-nitrosated napthalimide(NORM)at the same time.Since NO can react quickly with superoxide anion to generate ONOO−,the enhanced phototherapy could be achieved by in situ ONOO−produced by PCy7-NO upon exposure to the near infrared(NIR)light.Therefore,the NIR-triggered Cy7-based nanoplatform for ONOO−-enhanced phototherapy may provide a new perspective in cancer therapy.展开更多
基金the National Natural Science Foundation of China (Nos. 21662037, 21762045, 21911540466)Shandong Provincial Natural Science Foundation (No. ZR2019YQ12)+2 种基金China Postdoctoral Science Foundation (No. 219M652306)Taishan Scholar Project (No. tsqn 201812049) for supporting this worksupported through the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1A6A3A04004954) to S. Lee。
文摘The effective detecting ONOO^(-)variations in vivo is of great importance to well understand the complex pathophysiological processes. We reported here a photoacoustic(PA) probe AZB-1 for imaging ONOO;in vivo. AZB-1 showed an originally strong photoacoustic signal at 660 nm. And its PA signal can be turned off by shutting the ICT effect caused by the conjugated electron withdrawing group at 2-position of the aza-BODIPY core. Moreover, the probe was successfully employed to imaging ONOO^(-)variations in inflammatory mice models. Wisely utilized this strategy may serve as powerful platforms for the preparation of novel PA chemosensors.
基金by the National Natural Science Foundation of China(No.21875063)the Science and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program(No.19440710600).
文摘Phototherapies including photodynamic therapy(PDT)and photothermal therapy(PTT)are the most promising and non-invasive cancer treatments.However,the efficacy of mono-therapy of PDT or PTT is often limited by the phototherapeutic defects such as low light penetration depth of photosensitizers and insufficiency of photothermal agents.Peroxynitrite(ONOO−)has been proved to be an efficient oxidizing and nitrating agent that involves in various physiological and pathological processes.Therefore,ONOO−produced in tumor site could be an effective treatment in cancer therapy.Herein,a novel cyanine dye-based(Cy7)polymer nanoplatform is developed for enhanced phototherapy by in situ producing ONOO−.The Cy7 units in the nanoparticles can not only be served as the photosensitizer to produce reactive oxygen species(ROS)including singlet oxygen and superoxide anion for PDT,but also be used as a heat source for PTT and the release of NO gas from N-nitrosated napthalimide(NORM)at the same time.Since NO can react quickly with superoxide anion to generate ONOO−,the enhanced phototherapy could be achieved by in situ ONOO−produced by PCy7-NO upon exposure to the near infrared(NIR)light.Therefore,the NIR-triggered Cy7-based nanoplatform for ONOO−-enhanced phototherapy may provide a new perspective in cancer therapy.
