为改善一对多高斯过程分类器(one against all Gaussian process classifier,OAA-GPC)存在的不足,提出基于一对一方法的高斯过程多分类器(one against one Gaussian process classifier,OAO-GPC),以及在其基础上改进的基于有向无环图方...为改善一对多高斯过程分类器(one against all Gaussian process classifier,OAA-GPC)存在的不足,提出基于一对一方法的高斯过程多分类器(one against one Gaussian process classifier,OAO-GPC),以及在其基础上改进的基于有向无环图方法的高斯过程多分类器(directed acyclic graph Gaussian process classifier,DAG-GPC),这两种分类器在训练二分类器时仅需将其对应的两类训练样本作为输入,在不降低识别率的基础上减少算法的运行时间。在Oil、Segment、USPS这3个数据集上的实验结果表明,OAO-GPC和DAG-GPC的运行时间远低于OAA-GPC,且识别率与OAA-GPC近似相等,可迅速有效地解决样本的多分类问题。展开更多
Cancer nanomedicines require different,even opposite,properties to voyage the cascade drug delivery process involving a series of biological barriers.Currentlyapproved nanomedicines can only alleviate adverse effects ...Cancer nanomedicines require different,even opposite,properties to voyage the cascade drug delivery process involving a series of biological barriers.Currentlyapproved nanomedicines can only alleviate adverse effects but cannot improve patient survival because they fail to meet all the requirements.Therefore,nanocarriers with synchronized functions are highly requisite to capacitate efficient drug delivery and enhanced therapeutic efficacies.This perspective article summarizes recent advances in the two main strategies for nanomedicine design,the All-in-One approach(integration of all the functions in one system)and the One-for-All approach(one functional group with proper affinity enables all the functions),and presents our views on future nanomedicine development.展开更多
文摘为改善一对多高斯过程分类器(one against all Gaussian process classifier,OAA-GPC)存在的不足,提出基于一对一方法的高斯过程多分类器(one against one Gaussian process classifier,OAO-GPC),以及在其基础上改进的基于有向无环图方法的高斯过程多分类器(directed acyclic graph Gaussian process classifier,DAG-GPC),这两种分类器在训练二分类器时仅需将其对应的两类训练样本作为输入,在不降低识别率的基础上减少算法的运行时间。在Oil、Segment、USPS这3个数据集上的实验结果表明,OAO-GPC和DAG-GPC的运行时间远低于OAA-GPC,且识别率与OAA-GPC近似相等,可迅速有效地解决样本的多分类问题。
基金supported by the National Key Research and Development Program(2021YFA1201200)the National Natural Science Foundation of China(51833008 and 52203193)the Zhejiang Provincial Key Research and Development Program(2020C01123).
文摘Cancer nanomedicines require different,even opposite,properties to voyage the cascade drug delivery process involving a series of biological barriers.Currentlyapproved nanomedicines can only alleviate adverse effects but cannot improve patient survival because they fail to meet all the requirements.Therefore,nanocarriers with synchronized functions are highly requisite to capacitate efficient drug delivery and enhanced therapeutic efficacies.This perspective article summarizes recent advances in the two main strategies for nanomedicine design,the All-in-One approach(integration of all the functions in one system)and the One-for-All approach(one functional group with proper affinity enables all the functions),and presents our views on future nanomedicine development.
