Morinda citrifolia (noni) fruit juice has the potential to influence immune system function. This review discusses results from several human and animal studies that provide insight into the potential mechanisms of ac...Morinda citrifolia (noni) fruit juice has the potential to influence immune system function. This review discusses results from several human and animal studies that provide insight into the potential mechanisms of action by which noni juice exerts its immunomodulatory effects. Increased natural killer cell activity is a likely a major contributor to the improved health outcomes and increased survival times described in case reports and as observed in LLC and S180 tumor bearing mice. Increased interferon-gamma (IFN-γ) production is also an important mechanism of action through which noni improves immune function. IFN-γ promotes natural killer cell activity and phagocytosis, activities both seen in human and bovine studies as well as in rodents. Noni promotes regulatory cytokine expression, such as IL-2 which stimulates CD4+ T cell differentiation. Noni juice appears to influence this process via kinase 1/2 (ERK1/2), protein kinase B (Akt) and nuclear factor-kappa-beta signaling. As oxidative status is known to influence immune function, this review also discusses the notable antioxidant properties of noni juice that have been demonstrated in human trials.展开更多
Noni juice, made from the fruit of Morinda citrifolia, is a health-promoting food from the Pacific Islands with an extensive history of traditional use. Human clinical trials have revealed that noni juice has antioxid...Noni juice, made from the fruit of Morinda citrifolia, is a health-promoting food from the Pacific Islands with an extensive history of traditional use. Human clinical trials have revealed that noni juice has antioxidant, immunomodulatory and anti-inflammatory properties. Previously, regular noni juice consumers in Europe and traditional healers in Fiji were surveyed to identify potential noni juice health benefits. But to better understand the perception of its health benefits among those with no previous experience with noni juice, an in-home study was conducted in the United States. Three hundred and nineteen adults with untreated chronic health conditions were provided with a 90-day supply of a blinded (unlabeled) commercial noni juice product (Tahitian Noni<sup>®</sup> Juice), instructed to consume 4 fluid ounces (1/2 cup) each day, and responded to a questionnaire given on days 30, 60 and 90 to evaluate product appeal and perceived effectiveness. A total of 299 people (94%) felt that their health improved in some way after drinking TNJ for 90 days. More than 80% of the subjects reported feeling better or healthier in general. Most participants also concurred with more than two dozen additional positive health perception statements, especially on days 60 and 90. More than 70% of consumers also indicated that noni juice helped them feel better than other wellness supplements they had tried in the past, including other so-called “super fruit” products. These findings seem to corroborate the results of clinical trials and previous consumer surveys regarding the potential for noni juice to provide discernable health benefits when used consistently over time. Such findings may help guide additional placebo-controlled clinical trials in which specific effects may be evaluated more rigorously.展开更多
通过连续观测云南省热带作物科学研究所位于芒果山的橡胶种质圃和2006年建成的环境友好型生态胶园不同种植模式空气负氧离子(negative air ion,NAI)浓度,分析了负氧离子浓度变化特征及与相关影响因素之间的关系。结果表明:旱季纯胶林负...通过连续观测云南省热带作物科学研究所位于芒果山的橡胶种质圃和2006年建成的环境友好型生态胶园不同种植模式空气负氧离子(negative air ion,NAI)浓度,分析了负氧离子浓度变化特征及与相关影响因素之间的关系。结果表明:旱季纯胶林负氧离子浓度最高,其浓度为2980个/cm^(3),雨季和雾凉季均为绿肥地负氧离子浓度最高,浓度分别为5474、2208个/cm^(3),各季节橡胶种质圃负氧离子浓度均最低,分别为1890、2654、1685个/cm^(3);不同季节空气负氧离子浓度比较为:雨季(5-10月份)>旱季(2-4月份)>雾凉季(11月至翌年1月);不同种植模式空气负氧离子浓度比较为:绿肥>诺丽>用材林>纯林>种质圃;负氧离子浓度变化与空气湿度和空气含水量呈显著正相关,相关系数(R)分别为0.545和0.494,与空气相对湿度呈显著负相关,相关系数(R)为-0.169。展开更多
文摘Morinda citrifolia (noni) fruit juice has the potential to influence immune system function. This review discusses results from several human and animal studies that provide insight into the potential mechanisms of action by which noni juice exerts its immunomodulatory effects. Increased natural killer cell activity is a likely a major contributor to the improved health outcomes and increased survival times described in case reports and as observed in LLC and S180 tumor bearing mice. Increased interferon-gamma (IFN-γ) production is also an important mechanism of action through which noni improves immune function. IFN-γ promotes natural killer cell activity and phagocytosis, activities both seen in human and bovine studies as well as in rodents. Noni promotes regulatory cytokine expression, such as IL-2 which stimulates CD4+ T cell differentiation. Noni juice appears to influence this process via kinase 1/2 (ERK1/2), protein kinase B (Akt) and nuclear factor-kappa-beta signaling. As oxidative status is known to influence immune function, this review also discusses the notable antioxidant properties of noni juice that have been demonstrated in human trials.
文摘Noni juice, made from the fruit of Morinda citrifolia, is a health-promoting food from the Pacific Islands with an extensive history of traditional use. Human clinical trials have revealed that noni juice has antioxidant, immunomodulatory and anti-inflammatory properties. Previously, regular noni juice consumers in Europe and traditional healers in Fiji were surveyed to identify potential noni juice health benefits. But to better understand the perception of its health benefits among those with no previous experience with noni juice, an in-home study was conducted in the United States. Three hundred and nineteen adults with untreated chronic health conditions were provided with a 90-day supply of a blinded (unlabeled) commercial noni juice product (Tahitian Noni<sup>®</sup> Juice), instructed to consume 4 fluid ounces (1/2 cup) each day, and responded to a questionnaire given on days 30, 60 and 90 to evaluate product appeal and perceived effectiveness. A total of 299 people (94%) felt that their health improved in some way after drinking TNJ for 90 days. More than 80% of the subjects reported feeling better or healthier in general. Most participants also concurred with more than two dozen additional positive health perception statements, especially on days 60 and 90. More than 70% of consumers also indicated that noni juice helped them feel better than other wellness supplements they had tried in the past, including other so-called “super fruit” products. These findings seem to corroborate the results of clinical trials and previous consumer surveys regarding the potential for noni juice to provide discernable health benefits when used consistently over time. Such findings may help guide additional placebo-controlled clinical trials in which specific effects may be evaluated more rigorously.
文摘通过连续观测云南省热带作物科学研究所位于芒果山的橡胶种质圃和2006年建成的环境友好型生态胶园不同种植模式空气负氧离子(negative air ion,NAI)浓度,分析了负氧离子浓度变化特征及与相关影响因素之间的关系。结果表明:旱季纯胶林负氧离子浓度最高,其浓度为2980个/cm^(3),雨季和雾凉季均为绿肥地负氧离子浓度最高,浓度分别为5474、2208个/cm^(3),各季节橡胶种质圃负氧离子浓度均最低,分别为1890、2654、1685个/cm^(3);不同季节空气负氧离子浓度比较为:雨季(5-10月份)>旱季(2-4月份)>雾凉季(11月至翌年1月);不同种植模式空气负氧离子浓度比较为:绿肥>诺丽>用材林>纯林>种质圃;负氧离子浓度变化与空气湿度和空气含水量呈显著正相关,相关系数(R)分别为0.545和0.494,与空气相对湿度呈显著负相关,相关系数(R)为-0.169。
