Coke oven factories are one of the main emitting sources of polycyclic aromatic hydrocarbons (PAH)s which have been identified as highly carcinogenic chemicals by IARC. Induction of oxidative stress and following disr...Coke oven factories are one of the main emitting sources of polycyclic aromatic hydrocarbons (PAH)s which have been identified as highly carcinogenic chemicals by IARC. Induction of oxidative stress and following disrupting pathways has been repeatedly reported in subjects exposed to PAHs. This study was performed to monitor the oxidative stress markers, hematological and biochemical parameters, and psychological states in coke oven workers. 100 male subjects were included in this comparative cross-sectional study. At first 50 male workers who were 22 - 63 and worked in the steel factory located in South-East of Iran were contained. Control subjects were chosen from Esfahan, in the factory’s neighborhood, consisting of 50 office workers without any background of occupational exposure to metals. The blood levels of hematological factors and oxidative stress were measured. In order to compare data, two-sample t test was applied. In order to measure the correlation between variables, Pearson correlation coefficient was applied. The mean level of total antioxidant capacity, hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), and hematocrit were significantly lower in the workers in association with increased lipid per oxidation (LPO). A positive correlation existed between work history, hyper thyroids (r2 = 0.288, p = 0.01), and endocrine disorders (r2 = 0.309, p = 0.028). Occupational exposure of coke oven workers to PAHs can induce oxidative stress and consequent metabolic and neuropsychological disorders. When workers take daily shower and use protective tools, absorption of toxic elements would decrease so that reaching them to the body can be suitably limited.展开更多
目的探讨双相I型躁狂发作患者血清细胞因子水平及其与认知功能损害的相关性。方法纳入44例双相I型障碍躁狂发作患者(双相组)和42名人口学资料相匹配的健康志愿者(健康对照组)。采用酶联免疫吸附试验检测外周血清白细胞介素6(interleukin...目的探讨双相I型躁狂发作患者血清细胞因子水平及其与认知功能损害的相关性。方法纳入44例双相I型障碍躁狂发作患者(双相组)和42名人口学资料相匹配的健康志愿者(健康对照组)。采用酶联免疫吸附试验检测外周血清白细胞介素6(interleukin-6,IL-6)、白细胞介素10(IL-10)、白细胞介素23(IL-23)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平,使用重复性成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS)评定两组的认知功能,杨氏躁狂量表(Young manic rating scale,YMRS)评估患者的临床躁狂症状。采用SPSS 22.0进行假设检验和相关分析。结果(1)双相组血清细胞因子IL-6、IL-10、IL-23和TNF-α表达水平[分别为(38.872±7.803)pg/ml,(33.259±7.260)pg/ml,42.350(33.600,55.390)pg/ml,(108.309±19.398)pg/ml]与对照组相比[分别为(24.664±6.083)pg/ml,(29.257±5.208)pg/ml,17.360(12.870,30.690)pg/ml,(68.674±13.610)pg/ml],均差异具有统计学意义(t=9.387,t=2.947,Z=-5.477,t=10.921,均P<0.01)。(2)在RBANS认知测验中,双相组在视觉广度、注意、延时记忆和量表总分中所得的分数[(92.909±16.126)分,(83.091±8.529)分,(80.636±9.592)分,(416.318±33.438)分]与对照组[(82.905±10.958)分,(92.381±14.85)分,(93.714±7.613)分,(436.905±37.228)分]差异均具有统计学意义(t=3.378,t=-3.538,t=-6.982,t=-2.700,均P<0.05)。(3)相关性分析显示,双相组病程与细胞因子IL-6、IL-23水平呈正相关(r=00.509,r=0.298,P<0.05);视觉广度得分与IL-10和TNF-α水平呈正相关(r=0.426,r=0.647,均P<0.05);言语与IL-23水平呈负相关(r=-0.372,P<0.05);注意力得分与IL-6、IL-10和TNF-α呈负相关(r=-0.315,r=-0.318,r=-0.498,均P<0.05);延时记忆得分与IL-10和TNF-α呈负相关(r=-0.360,r=-0.621,均P<0.05)。未发现YMRS评分、即刻记忆量表得分与细胞因子存在相关性(P>0.05)。结论双相I型障碍躁狂发作患者血清细胞因子水平存在变化,部分认知�展开更多
目的探索缺血性深部脑白质损害(deep white matter lesions,DWMLs)患者的认知障碍特征及与不同脑区皮层功能之间的关系。方法纳入2016-2018年我科门诊及住院的轻度缺血性深部脑白质损害患者38名,依据患者有无认知障碍分为认知障碍组及...目的探索缺血性深部脑白质损害(deep white matter lesions,DWMLs)患者的认知障碍特征及与不同脑区皮层功能之间的关系。方法纳入2016-2018年我科门诊及住院的轻度缺血性深部脑白质损害患者38名,依据患者有无认知障碍分为认知障碍组及认知正常组,同时匹配对照组18名(颅脑核磁共振证实未见白质病变且认知功能正常的老年体检人群)。采用神经心理量表及静息态功能磁共振的比率低频振幅值分析深部脑白质损害患者认知障碍的特点以及功能异常的皮层脑区。结果深部脑白质损害患者的执行功能、注意功能、记忆功能和视空间功能均显著降低(P<0.05),其中执行、注意功能损害在认知障碍的早期阶段出现。通过静息态功能核磁共振检查发现:与对照组比较,深部脑白质损害伴认知障碍患者的双侧额中回、双侧楔叶、左侧楔前叶、左侧前扣带回、双侧颞中回、左侧枕颞内侧回的比率低频振幅值降低(P<0.05),同时,左侧海马杏仁核、左侧顶上回、左侧小脑蚓部的比率低频振幅值升高(P<0.05)。与对照组比较,深部脑白质损害认知正常患者的双侧额中回、左侧前扣带回、双侧颞中回的比率低频振幅值降低(P<0.05),无比率低频振幅值明显升高的脑区。Pearson相关性分析发现:上述功能异常脑区均与深部脑白质损害患者的认知障碍具有显著相关性。结论深部脑白质损害可导致执行功能、注意功能、记忆功能和视空间功能下降,其中执行、注意功能下降是深部脑白质损害导致认知障碍的首发症状。缺血性DWMLs患者的多个脑区皮层功能下降,而且与认知障碍相关。皮层功能损害可能是缺血性DWMLs所致认知障碍的原因之一。展开更多
文摘Coke oven factories are one of the main emitting sources of polycyclic aromatic hydrocarbons (PAH)s which have been identified as highly carcinogenic chemicals by IARC. Induction of oxidative stress and following disrupting pathways has been repeatedly reported in subjects exposed to PAHs. This study was performed to monitor the oxidative stress markers, hematological and biochemical parameters, and psychological states in coke oven workers. 100 male subjects were included in this comparative cross-sectional study. At first 50 male workers who were 22 - 63 and worked in the steel factory located in South-East of Iran were contained. Control subjects were chosen from Esfahan, in the factory’s neighborhood, consisting of 50 office workers without any background of occupational exposure to metals. The blood levels of hematological factors and oxidative stress were measured. In order to compare data, two-sample t test was applied. In order to measure the correlation between variables, Pearson correlation coefficient was applied. The mean level of total antioxidant capacity, hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), and hematocrit were significantly lower in the workers in association with increased lipid per oxidation (LPO). A positive correlation existed between work history, hyper thyroids (r2 = 0.288, p = 0.01), and endocrine disorders (r2 = 0.309, p = 0.028). Occupational exposure of coke oven workers to PAHs can induce oxidative stress and consequent metabolic and neuropsychological disorders. When workers take daily shower and use protective tools, absorption of toxic elements would decrease so that reaching them to the body can be suitably limited.
文摘目的探讨双相I型躁狂发作患者血清细胞因子水平及其与认知功能损害的相关性。方法纳入44例双相I型障碍躁狂发作患者(双相组)和42名人口学资料相匹配的健康志愿者(健康对照组)。采用酶联免疫吸附试验检测外周血清白细胞介素6(interleukin-6,IL-6)、白细胞介素10(IL-10)、白细胞介素23(IL-23)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平,使用重复性成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS)评定两组的认知功能,杨氏躁狂量表(Young manic rating scale,YMRS)评估患者的临床躁狂症状。采用SPSS 22.0进行假设检验和相关分析。结果(1)双相组血清细胞因子IL-6、IL-10、IL-23和TNF-α表达水平[分别为(38.872±7.803)pg/ml,(33.259±7.260)pg/ml,42.350(33.600,55.390)pg/ml,(108.309±19.398)pg/ml]与对照组相比[分别为(24.664±6.083)pg/ml,(29.257±5.208)pg/ml,17.360(12.870,30.690)pg/ml,(68.674±13.610)pg/ml],均差异具有统计学意义(t=9.387,t=2.947,Z=-5.477,t=10.921,均P<0.01)。(2)在RBANS认知测验中,双相组在视觉广度、注意、延时记忆和量表总分中所得的分数[(92.909±16.126)分,(83.091±8.529)分,(80.636±9.592)分,(416.318±33.438)分]与对照组[(82.905±10.958)分,(92.381±14.85)分,(93.714±7.613)分,(436.905±37.228)分]差异均具有统计学意义(t=3.378,t=-3.538,t=-6.982,t=-2.700,均P<0.05)。(3)相关性分析显示,双相组病程与细胞因子IL-6、IL-23水平呈正相关(r=00.509,r=0.298,P<0.05);视觉广度得分与IL-10和TNF-α水平呈正相关(r=0.426,r=0.647,均P<0.05);言语与IL-23水平呈负相关(r=-0.372,P<0.05);注意力得分与IL-6、IL-10和TNF-α呈负相关(r=-0.315,r=-0.318,r=-0.498,均P<0.05);延时记忆得分与IL-10和TNF-α呈负相关(r=-0.360,r=-0.621,均P<0.05)。未发现YMRS评分、即刻记忆量表得分与细胞因子存在相关性(P>0.05)。结论双相I型障碍躁狂发作患者血清细胞因子水平存在变化,部分认知�
文摘目的探索缺血性深部脑白质损害(deep white matter lesions,DWMLs)患者的认知障碍特征及与不同脑区皮层功能之间的关系。方法纳入2016-2018年我科门诊及住院的轻度缺血性深部脑白质损害患者38名,依据患者有无认知障碍分为认知障碍组及认知正常组,同时匹配对照组18名(颅脑核磁共振证实未见白质病变且认知功能正常的老年体检人群)。采用神经心理量表及静息态功能磁共振的比率低频振幅值分析深部脑白质损害患者认知障碍的特点以及功能异常的皮层脑区。结果深部脑白质损害患者的执行功能、注意功能、记忆功能和视空间功能均显著降低(P<0.05),其中执行、注意功能损害在认知障碍的早期阶段出现。通过静息态功能核磁共振检查发现:与对照组比较,深部脑白质损害伴认知障碍患者的双侧额中回、双侧楔叶、左侧楔前叶、左侧前扣带回、双侧颞中回、左侧枕颞内侧回的比率低频振幅值降低(P<0.05),同时,左侧海马杏仁核、左侧顶上回、左侧小脑蚓部的比率低频振幅值升高(P<0.05)。与对照组比较,深部脑白质损害认知正常患者的双侧额中回、左侧前扣带回、双侧颞中回的比率低频振幅值降低(P<0.05),无比率低频振幅值明显升高的脑区。Pearson相关性分析发现:上述功能异常脑区均与深部脑白质损害患者的认知障碍具有显著相关性。结论深部脑白质损害可导致执行功能、注意功能、记忆功能和视空间功能下降,其中执行、注意功能下降是深部脑白质损害导致认知障碍的首发症状。缺血性DWMLs患者的多个脑区皮层功能下降,而且与认知障碍相关。皮层功能损害可能是缺血性DWMLs所致认知障碍的原因之一。
